TY - JOUR
T1 - Volumen plaquetario medio como predictor de la mortalidad en pacientes con sepsis
T2 - Revisión sistemática y metanálisis
AU - Vélez-Paez, Jorge Luis
AU - Velarde-Montero, Carlos
AU - Irigoyen-Mogro, Estefanía
AU - Vélez-Páez, Pablo
AU - Cifuentes-López, Paulina
AU - Vélez, Jorge W.
AU - Albitres-Flores, Leonardo
AU - Barboza, Joshuan J.
N1 - Publisher Copyright:
© 2020 Korean Pain Society. All rights reserved.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020
Y1 - 2020
N2 - Introduction: Platelet mean volume (MVP) is a biomarker used in the integral approach to sepsis. Objective: To assess the association between MVP and mortality in patients with sepsis. Methods: A systematic review of observational studies in five databases was performed. Mortality associated with sepsis was analysed; interventions considered were MPV, APACHE and serum lactate. Results: Regarding mortality associated with sepsis, a significant value was found in the MVP at 72 hours (200 deceased versus 654 not deceased; MD 0.83 IC95% 0.53-1.13, p= <0.0001, I2=72.9%); as well as the value of APACHE II (220 dead versus 604 not deceased; MD 0.81 IC95% 0.62-1.0, p= <0.0001, I2=32%). No statistical significance was found for the other clinical variables. Conclusions: Increased MVP is associated with increased risk of mortality in patients with sepsis, especially after 72 hours of evolution of clinical features.
AB - Introduction: Platelet mean volume (MVP) is a biomarker used in the integral approach to sepsis. Objective: To assess the association between MVP and mortality in patients with sepsis. Methods: A systematic review of observational studies in five databases was performed. Mortality associated with sepsis was analysed; interventions considered were MPV, APACHE and serum lactate. Results: Regarding mortality associated with sepsis, a significant value was found in the MVP at 72 hours (200 deceased versus 654 not deceased; MD 0.83 IC95% 0.53-1.13, p= <0.0001, I2=72.9%); as well as the value of APACHE II (220 dead versus 604 not deceased; MD 0.81 IC95% 0.62-1.0, p= <0.0001, I2=32%). No statistical significance was found for the other clinical variables. Conclusions: Increased MVP is associated with increased risk of mortality in patients with sepsis, especially after 72 hours of evolution of clinical features.
KW - Mean Platelet Volume
KW - Mortality
KW - Sepsis
KW - Systematic Review
UR - http://www.scopus.com/inward/record.url?scp=85091123415&partnerID=8YFLogxK
U2 - 10.22354/in.v24i3.861
DO - 10.22354/in.v24i3.861
M3 - Artículo
AN - SCOPUS:85091123415
SN - 0123-9392
VL - 24
SP - 162
EP - 168
JO - Infectio
JF - Infectio
IS - 3
ER -