TY - JOUR
T1 - Very low prevalence of ultrasound-detected tenosynovial abnormalities in healthy subjects throughout the age range
T2 - OMERACT ultrasound minimal disease study
AU - Trickey, Jeanette
AU - Sahbudin, Ilfita
AU - Ammitzbøll-Danielsen, Mads
AU - Azzolin, Irene
AU - Borst, Carina
AU - Bortoluzzi, Alessandra
AU - Bruyn, George A.W.
AU - Carron, Philippe
AU - Ciurtin, Coziana
AU - Filippou, Georgios
AU - Fliciński, Jacek
AU - Fodor, Daniela
AU - Gouze, Hélène
AU - Gutierrez, Marwin
AU - Hammer, Hilde Berner
AU - Hauge, Ellen Margrethe
AU - Iagnocco, Annamaria
AU - Ikeda, Kei
AU - Karalilova, Rositsa
AU - Keen, Helen Isobel
AU - Kortekaas, Marion
AU - Paglia, Giuliana La
AU - Leon, Gustavo
AU - Mandl, Peter
AU - Maruseac, Mihaela
AU - Milchert, Marcin
AU - Mortada, Mohamed Atia
AU - Naredo, Esperanza
AU - Ohrndorf, Sarah
AU - Pineda, Carlos
AU - Rasch, Mads Nyhuus Bendix
AU - Reátegui-Sokolova, Cristina
AU - Sakellariou, Garifallia
AU - Serban, Teodora
AU - Sifuentes-Cantú, Cesar A.
AU - Stoenoiu, Maria S.
AU - Suzuki, Takeshi
AU - Terslev, Lene
AU - Tinazzi, Ilaria
AU - Vreju, Florentin Ananu
AU - Wittoek, Ruth
AU - D’Agostino, Maria Antonietta
AU - Filer, Andrew
N1 - Publisher Copyright:
© Author(s) (or their employer(s)) 2022.
PY - 2022/2
Y1 - 2022/2
N2 - Objectives This study aimed to determine the prevalence of ultrasound-detected tendon abnormalities in healthy subjects (HS) across the age range. Methods Adult HS (age 18–80 years) were recruited in 23 international Outcome Measures in Rheumatology ultrasound centres and were clinically assessed to exclude inflammatory diseases or overt osteoarthritis before undergoing a bilateral ultrasound examination of digit flexors (DFs) 1–5 and extensor carpi ulnaris (ECU) tendons to detect the presence of tenosynovial hypertrophy (TSH), tenosynovial power Doppler (TPD) and tenosynovial effusion (TEF), usually considered ultrasound signs of inflammatory diseases. A comparison cohort of patients with rheumatoid arthritis (RA) was taken from the Birmingham Early Arthritis early arthritis inception cohort. Results 939 HS and 144 patients with RA were included. The majority of HS (85%) had grade 0 for TSH, TPD and TEF in all DF and ECU tendons examined. There was a statistically significant difference in the proportion of TSH and TPD involvement between HS and subjects with RA (HS vs RA p<0.001). In HS, there was no difference in the presence of ultrasound abnormalities between age groups. Conclusions Ultrasound-detected TSH and TPD abnormalities are rare in HS and can be regarded as markers of active inflammatory disease, especially in newly presenting RA.
AB - Objectives This study aimed to determine the prevalence of ultrasound-detected tendon abnormalities in healthy subjects (HS) across the age range. Methods Adult HS (age 18–80 years) were recruited in 23 international Outcome Measures in Rheumatology ultrasound centres and were clinically assessed to exclude inflammatory diseases or overt osteoarthritis before undergoing a bilateral ultrasound examination of digit flexors (DFs) 1–5 and extensor carpi ulnaris (ECU) tendons to detect the presence of tenosynovial hypertrophy (TSH), tenosynovial power Doppler (TPD) and tenosynovial effusion (TEF), usually considered ultrasound signs of inflammatory diseases. A comparison cohort of patients with rheumatoid arthritis (RA) was taken from the Birmingham Early Arthritis early arthritis inception cohort. Results 939 HS and 144 patients with RA were included. The majority of HS (85%) had grade 0 for TSH, TPD and TEF in all DF and ECU tendons examined. There was a statistically significant difference in the proportion of TSH and TPD involvement between HS and subjects with RA (HS vs RA p<0.001). In HS, there was no difference in the presence of ultrasound abnormalities between age groups. Conclusions Ultrasound-detected TSH and TPD abnormalities are rare in HS and can be regarded as markers of active inflammatory disease, especially in newly presenting RA.
KW - rheumatoid arthritis
KW - tendinopathy
KW - ultrasonography
KW - Tenosynovitis/diagnostic imaging
KW - Prevalence
KW - Humans
KW - Middle Aged
KW - Male
KW - Tendons/diagnostic imaging
KW - Healthy Volunteers
KW - Hypertrophy/diagnostic imaging
KW - Young Adult
KW - Adolescent
KW - Ultrasonography
KW - Aged, 80 and over
KW - Adult
KW - Female
KW - Aged
KW - Cohort Studies
UR - http://www.scopus.com/inward/record.url?scp=85122277231&partnerID=8YFLogxK
U2 - 10.1136/annrheumdis-2021-219931
DO - 10.1136/annrheumdis-2021-219931
M3 - Artículo
C2 - 34407928
AN - SCOPUS:85122277231
SN - 0003-4967
VL - 81
SP - 232
EP - 236
JO - Annals of the Rheumatic Diseases
JF - Annals of the Rheumatic Diseases
IS - 2
ER -