TY - JOUR
T1 - Very low prevalence of ultrasound-detected tenosynovial abnormalities in healthy subjects throughout the age range
T2 - OMERACT ultrasound minimal disease study
AU - Trickey, Jeanette
AU - Sahbudin, Ilfita
AU - Ammitzbøll-Danielsen, Mads
AU - Azzolin, Irene
AU - Borst, Carina
AU - Bortoluzzi, Alessandra
AU - Bruyn, George Aw
AU - Carron, Philippe
AU - Ciurtin, Coziana
AU - Filippou, Georgios
AU - Fliciński, Jacek
AU - Fodor, Daniela
AU - Gouze, Hélène
AU - Gutierrez, Marwin
AU - Hammer, Hilde Berner
AU - Hauge, Ellen Margrethe
AU - Iagnocco, Annamaria
AU - Ikeda, Kei
AU - Karalilova, Rositsa
AU - Keen, Helen Isobel
AU - Kortekaas, Marion
AU - La Paglia, Giuliana
AU - Leon, Gustavo
AU - Mandl, Peter
AU - Maruseac, Mihaela
AU - Milchert, Marcin
AU - Mortada, Mohamed Atia
AU - Naredo, Esperanza
AU - Ohrndorf, Sarah
AU - Pineda, Carlos
AU - Rasch, Mads Nyhuus Bendix
AU - Reátegui-Sokolova, Cristina
AU - Sakellariou, Garifallia
AU - Serban, Teodora
AU - Sifuentes-Cantú, Cesar A.
AU - Stoenoiu, Maria S.
AU - Suzuki, Takeshi
AU - Terslev, Lene
AU - Tinazzi, Ilaria
AU - Vreju, Florentin Ananu
AU - Wittoek, Ruth
AU - D'Agostino, Maria Antonietta
AU - Filer, Andrew
N1 - Publisher Copyright:
© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ.
PY - 2022/2/1
Y1 - 2022/2/1
N2 - OBJECTIVES: This study aimed to determine the prevalence of ultrasound-detected tendon abnormalities in healthy subjects (HS) across the age range. METHODS: Adult HS (age 18-80 years) were recruited in 23 international Outcome Measures in Rheumatology ultrasound centres and were clinically assessed to exclude inflammatory diseases or overt osteoarthritis before undergoing a bilateral ultrasound examination of digit flexors (DFs) 1-5 and extensor carpi ulnaris (ECU) tendons to detect the presence of tenosynovial hypertrophy (TSH), tenosynovial power Doppler (TPD) and tenosynovial effusion (TEF), usually considered ultrasound signs of inflammatory diseases. A comparison cohort of patients with rheumatoid arthritis (RA) was taken from the Birmingham Early Arthritis early arthritis inception cohort. RESULTS: 939 HS and 144 patients with RA were included. The majority of HS (85%) had grade 0 for TSH, TPD and TEF in all DF and ECU tendons examined. There was a statistically significant difference in the proportion of TSH and TPD involvement between HS and subjects with RA (HS vs RA p<0.001). In HS, there was no difference in the presence of ultrasound abnormalities between age groups. CONCLUSIONS: Ultrasound-detected TSH and TPD abnormalities are rare in HS and can be regarded as markers of active inflammatory disease, especially in newly presenting RA.
AB - OBJECTIVES: This study aimed to determine the prevalence of ultrasound-detected tendon abnormalities in healthy subjects (HS) across the age range. METHODS: Adult HS (age 18-80 years) were recruited in 23 international Outcome Measures in Rheumatology ultrasound centres and were clinically assessed to exclude inflammatory diseases or overt osteoarthritis before undergoing a bilateral ultrasound examination of digit flexors (DFs) 1-5 and extensor carpi ulnaris (ECU) tendons to detect the presence of tenosynovial hypertrophy (TSH), tenosynovial power Doppler (TPD) and tenosynovial effusion (TEF), usually considered ultrasound signs of inflammatory diseases. A comparison cohort of patients with rheumatoid arthritis (RA) was taken from the Birmingham Early Arthritis early arthritis inception cohort. RESULTS: 939 HS and 144 patients with RA were included. The majority of HS (85%) had grade 0 for TSH, TPD and TEF in all DF and ECU tendons examined. There was a statistically significant difference in the proportion of TSH and TPD involvement between HS and subjects with RA (HS vs RA p<0.001). In HS, there was no difference in the presence of ultrasound abnormalities between age groups. CONCLUSIONS: Ultrasound-detected TSH and TPD abnormalities are rare in HS and can be regarded as markers of active inflammatory disease, especially in newly presenting RA.
KW - rheumatoid arthritis
KW - tendinopathy
KW - ultrasonography
KW - Tenosynovitis/diagnostic imaging
KW - Prevalence
KW - Humans
KW - Middle Aged
KW - Male
KW - Tendons/diagnostic imaging
KW - Healthy Volunteers
KW - Hypertrophy/diagnostic imaging
KW - Young Adult
KW - Adolescent
KW - Ultrasonography
KW - Aged, 80 and over
KW - Adult
KW - Female
KW - Aged
KW - Cohort Studies
UR - http://www.scopus.com/inward/record.url?scp=85122277231&partnerID=8YFLogxK
U2 - 10.1136/annrheumdis-2021-219931
DO - 10.1136/annrheumdis-2021-219931
M3 - Artículo
C2 - 34407928
AN - SCOPUS:85122277231
SN - 0003-4967
VL - 81
SP - 232
EP - 236
JO - Annals of the Rheumatic Diseases
JF - Annals of the Rheumatic Diseases
IS - 2
ER -