TY - JOUR
T1 - Uso de fosfomicina comparado con ceftriaxona y meropenem para el tratamiento de las infecciones urinarias por Escherichia coli multirresistente (estudio FOREST)
T2 - Valoración crítica del artículo
AU - Zela-Coila, Frank
AU - Vizcarra-Jiménez, Sonia
AU - Taype-Rondan, Alvaro
N1 - Publisher Copyright:
© 2023 Medical Body of the Almanzor Aguinaga Asenjo National Hospital. All rights reserved.
PY - 2023
Y1 - 2023
N2 - Presentation: In this article, we present our critical assessment of a pragmatic clinical trial published in the Jama Network Open journal in the year 2022. Study conclusions: The study fails to demonstrate the non-inferiority of 4g of intravenous disodium fosfomycin every 6 hours over 60 minutes compared to ceftriaxone (1g of intravenous ceftriaxone every 24 hours over 2-4 minutes) or, if resistant to ceftriaxone, meropenem (1g of intravenous meropenem every 8 hours over 15-30 minutes). Critical comment: The article is relevant because bacterial resistance is currently of interest for the proper management of urinary tract infections. Therefore, alternatives that are not empirically used are being sought. However, the study has limitations such as not reaching the calculated sample size, having a low margin of noninferiority, and the lack of blinding in the intervention.
AB - Presentation: In this article, we present our critical assessment of a pragmatic clinical trial published in the Jama Network Open journal in the year 2022. Study conclusions: The study fails to demonstrate the non-inferiority of 4g of intravenous disodium fosfomycin every 6 hours over 60 minutes compared to ceftriaxone (1g of intravenous ceftriaxone every 24 hours over 2-4 minutes) or, if resistant to ceftriaxone, meropenem (1g of intravenous meropenem every 8 hours over 15-30 minutes). Critical comment: The article is relevant because bacterial resistance is currently of interest for the proper management of urinary tract infections. Therefore, alternatives that are not empirically used are being sought. However, the study has limitations such as not reaching the calculated sample size, having a low margin of noninferiority, and the lack of blinding in the intervention.
UR - http://www.scopus.com/inward/record.url?scp=85185297930&partnerID=8YFLogxK
U2 - 10.35434/rcmhnaaa.2023.163.1948
DO - 10.35434/rcmhnaaa.2023.163.1948
M3 - Artículo
AN - SCOPUS:85185297930
SN - 2225-5109
VL - 16
JO - Revista del Cuerpo Medico Hospital Nacional Almanzor Aguinaga Asenjo
JF - Revista del Cuerpo Medico Hospital Nacional Almanzor Aguinaga Asenjo
IS - 3
ER -