THU0648 Work disability in a Peruvian cohort of systemic lupus erythematosus patients

Cristina Reategui Sokolova, Claudia Elera-Fitzcarrald, Rocío Violeta Gamboa Cárdenas, Mariela Medina, Francisco Zevallos Miranda, Paola Alejandra Zeña Huancas, Victor Pimentel Quiroz, Jorge-M Cucho-V, Cesar Pastor Asurza, Zoila Rodriguez Bellido, Risto Perich Campos, Graciela S Alarcon, Manuel F. Ugarte-Gil

Resultado de la investigación: Contribución a una revistaResumen de conferenciaInvestigaciónrevisión exhaustiva

Resumen

Background: Work disability in patients with systemic lupus erythematosus (SLE) is common but the factors associated with it in Low and Middle Income Countries have been scarcely evaluated(1).

Objectives: To determine the prevalence of and the factors associated with work disability in SLE patients.

Methods: We studied 239 consecutive (1997 American College of Rheumatology (ACR) criteria) patients from a Peruvian SLE cohort from October 2017 to December 2018. Work disability was measured from a single self-report questionnaire. Data were collected and included sociodemographic information, clinical lupus features including disease activity [Systemic Lupus Erythematosus Disease Activity Index 2000 update (SLEDAI-2K)], damage [Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI)], as well as Health-Related Quality of Life (LupusQoL), and medication use. Work disability was defined by patients’ self-report of not being able to work because of SLE. Univariable analysis comparing those patients with work disability and those who remained working were performed with the Mann Whitney U test for continuous variables and the Chi-square test for dichotomous variables. For the multivariable analyses, binary logistic regression with backward elimination was used to determine which factors remained associated with work disability.

Results: Of 239 patients, 194 patients were working at least for at least some time since diagnosis, 181 (93.0%) were female, they had a mean age at diagnosis of 34.5 (12.3) years, and a mean disease duration of 11.5 (7.4) years, their mean SLEDAI was 2.53 (3.7) and their mean SDI was 1.2 (1.5). Twenty-eight patients changed their activities at work due to SLE and 51 (26.6%) stopped working after their diagnosis; 21 of them (41.1%) stopped working because of SLE. One hundred and forty-three were working at the time of the evaluation. In the multivariate analyses, those work- disabled due to SLE were more likely to have higher SDI: OR=1.650 (CI95%: 1.134-2.403) p=0.009, and lower HRQoL in two domains, planning: OR=0.975 (CI 95%: 0.954-0.996) p=0.020 and body image OR=0.977 (CI95%: 0.956, 0.998), p=0.032.

Conclusion: Work disability due to SLE is associated with higher damage accrual and a poorer HRQoL.
Idioma originalInglés
PublicaciónAnnals of the Rheumatic Diseases
DOI
EstadoPublicada - jun 2019

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Sokolova, C. R., Elera-Fitzcarrald, C., Cárdenas, R. V. G., Medina, M., Miranda, F. Z., Huancas, P. A. Z., ... Ugarte-Gil, M. F. (2019). THU0648 Work disability in a Peruvian cohort of systemic lupus erythematosus patients. Annals of the Rheumatic Diseases. https://doi.org/10.1136/annrheumdis-2019-eular.6533
Sokolova, Cristina Reategui ; Elera-Fitzcarrald, Claudia ; Cárdenas, Rocío Violeta Gamboa ; Medina, Mariela ; Miranda, Francisco Zevallos ; Huancas, Paola Alejandra Zeña ; Quiroz, Victor Pimentel ; Cucho-V, Jorge-M ; Asurza, Cesar Pastor ; Bellido, Zoila Rodriguez ; Campos, Risto Perich ; Alarcon, Graciela S ; Ugarte-Gil, Manuel F. / THU0648 Work disability in a Peruvian cohort of systemic lupus erythematosus patients. En: Annals of the Rheumatic Diseases. 2019.
@article{eec8de391db241a78ae7e7d7492202fe,
title = "THU0648 Work disability in a Peruvian cohort of systemic lupus erythematosus patients",
abstract = "Background: Work disability in patients with systemic lupus erythematosus (SLE) is common but the factors associated with it in Low and Middle Income Countries have been scarcely evaluated(1).Objectives: To determine the prevalence of and the factors associated with work disability in SLE patients.Methods: We studied 239 consecutive (1997 American College of Rheumatology (ACR) criteria) patients from a Peruvian SLE cohort from October 2017 to December 2018. Work disability was measured from a single self-report questionnaire. Data were collected and included sociodemographic information, clinical lupus features including disease activity [Systemic Lupus Erythematosus Disease Activity Index 2000 update (SLEDAI-2K)], damage [Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI)], as well as Health-Related Quality of Life (LupusQoL), and medication use. Work disability was defined by patients’ self-report of not being able to work because of SLE. Univariable analysis comparing those patients with work disability and those who remained working were performed with the Mann Whitney U test for continuous variables and the Chi-square test for dichotomous variables. For the multivariable analyses, binary logistic regression with backward elimination was used to determine which factors remained associated with work disability.Results: Of 239 patients, 194 patients were working at least for at least some time since diagnosis, 181 (93.0{\%}) were female, they had a mean age at diagnosis of 34.5 (12.3) years, and a mean disease duration of 11.5 (7.4) years, their mean SLEDAI was 2.53 (3.7) and their mean SDI was 1.2 (1.5). Twenty-eight patients changed their activities at work due to SLE and 51 (26.6{\%}) stopped working after their diagnosis; 21 of them (41.1{\%}) stopped working because of SLE. One hundred and forty-three were working at the time of the evaluation. In the multivariate analyses, those work- disabled due to SLE were more likely to have higher SDI: OR=1.650 (CI95{\%}: 1.134-2.403) p=0.009, and lower HRQoL in two domains, planning: OR=0.975 (CI 95{\%}: 0.954-0.996) p=0.020 and body image OR=0.977 (CI95{\%}: 0.956, 0.998), p=0.032.Conclusion: Work disability due to SLE is associated with higher damage accrual and a poorer HRQoL.",
author = "Sokolova, {Cristina Reategui} and Claudia Elera-Fitzcarrald and C{\'a}rdenas, {Roc{\'i}o Violeta Gamboa} and Mariela Medina and Miranda, {Francisco Zevallos} and Huancas, {Paola Alejandra Ze{\~n}a} and Quiroz, {Victor Pimentel} and Jorge-M Cucho-V and Asurza, {Cesar Pastor} and Bellido, {Zoila Rodriguez} and Campos, {Risto Perich} and Alarcon, {Graciela S} and Ugarte-Gil, {Manuel F.}",
year = "2019",
month = "6",
doi = "10.1136/annrheumdis-2019-eular.6533",
language = "Ingl{\'e}s",
journal = "Annals of the Rheumatic Diseases",

}

Sokolova, CR, Elera-Fitzcarrald, C, Cárdenas, RVG, Medina, M, Miranda, FZ, Huancas, PAZ, Quiroz, VP, Cucho-V, J-M, Asurza, CP, Bellido, ZR, Campos, RP, Alarcon, GS & Ugarte-Gil, MF 2019, 'THU0648 Work disability in a Peruvian cohort of systemic lupus erythematosus patients', Annals of the Rheumatic Diseases. https://doi.org/10.1136/annrheumdis-2019-eular.6533

THU0648 Work disability in a Peruvian cohort of systemic lupus erythematosus patients. / Sokolova, Cristina Reategui; Elera-Fitzcarrald, Claudia; Cárdenas, Rocío Violeta Gamboa; Medina, Mariela; Miranda, Francisco Zevallos; Huancas, Paola Alejandra Zeña; Quiroz, Victor Pimentel; Cucho-V, Jorge-M; Asurza, Cesar Pastor; Bellido, Zoila Rodriguez; Campos, Risto Perich; Alarcon, Graciela S; Ugarte-Gil, Manuel F.

En: Annals of the Rheumatic Diseases, 06.2019.

Resultado de la investigación: Contribución a una revistaResumen de conferenciaInvestigaciónrevisión exhaustiva

TY - JOUR

T1 - THU0648 Work disability in a Peruvian cohort of systemic lupus erythematosus patients

AU - Sokolova, Cristina Reategui

AU - Elera-Fitzcarrald, Claudia

AU - Cárdenas, Rocío Violeta Gamboa

AU - Medina, Mariela

AU - Miranda, Francisco Zevallos

AU - Huancas, Paola Alejandra Zeña

AU - Quiroz, Victor Pimentel

AU - Cucho-V, Jorge-M

AU - Asurza, Cesar Pastor

AU - Bellido, Zoila Rodriguez

AU - Campos, Risto Perich

AU - Alarcon, Graciela S

AU - Ugarte-Gil, Manuel F.

PY - 2019/6

Y1 - 2019/6

N2 - Background: Work disability in patients with systemic lupus erythematosus (SLE) is common but the factors associated with it in Low and Middle Income Countries have been scarcely evaluated(1).Objectives: To determine the prevalence of and the factors associated with work disability in SLE patients.Methods: We studied 239 consecutive (1997 American College of Rheumatology (ACR) criteria) patients from a Peruvian SLE cohort from October 2017 to December 2018. Work disability was measured from a single self-report questionnaire. Data were collected and included sociodemographic information, clinical lupus features including disease activity [Systemic Lupus Erythematosus Disease Activity Index 2000 update (SLEDAI-2K)], damage [Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI)], as well as Health-Related Quality of Life (LupusQoL), and medication use. Work disability was defined by patients’ self-report of not being able to work because of SLE. Univariable analysis comparing those patients with work disability and those who remained working were performed with the Mann Whitney U test for continuous variables and the Chi-square test for dichotomous variables. For the multivariable analyses, binary logistic regression with backward elimination was used to determine which factors remained associated with work disability.Results: Of 239 patients, 194 patients were working at least for at least some time since diagnosis, 181 (93.0%) were female, they had a mean age at diagnosis of 34.5 (12.3) years, and a mean disease duration of 11.5 (7.4) years, their mean SLEDAI was 2.53 (3.7) and their mean SDI was 1.2 (1.5). Twenty-eight patients changed their activities at work due to SLE and 51 (26.6%) stopped working after their diagnosis; 21 of them (41.1%) stopped working because of SLE. One hundred and forty-three were working at the time of the evaluation. In the multivariate analyses, those work- disabled due to SLE were more likely to have higher SDI: OR=1.650 (CI95%: 1.134-2.403) p=0.009, and lower HRQoL in two domains, planning: OR=0.975 (CI 95%: 0.954-0.996) p=0.020 and body image OR=0.977 (CI95%: 0.956, 0.998), p=0.032.Conclusion: Work disability due to SLE is associated with higher damage accrual and a poorer HRQoL.

AB - Background: Work disability in patients with systemic lupus erythematosus (SLE) is common but the factors associated with it in Low and Middle Income Countries have been scarcely evaluated(1).Objectives: To determine the prevalence of and the factors associated with work disability in SLE patients.Methods: We studied 239 consecutive (1997 American College of Rheumatology (ACR) criteria) patients from a Peruvian SLE cohort from October 2017 to December 2018. Work disability was measured from a single self-report questionnaire. Data were collected and included sociodemographic information, clinical lupus features including disease activity [Systemic Lupus Erythematosus Disease Activity Index 2000 update (SLEDAI-2K)], damage [Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI)], as well as Health-Related Quality of Life (LupusQoL), and medication use. Work disability was defined by patients’ self-report of not being able to work because of SLE. Univariable analysis comparing those patients with work disability and those who remained working were performed with the Mann Whitney U test for continuous variables and the Chi-square test for dichotomous variables. For the multivariable analyses, binary logistic regression with backward elimination was used to determine which factors remained associated with work disability.Results: Of 239 patients, 194 patients were working at least for at least some time since diagnosis, 181 (93.0%) were female, they had a mean age at diagnosis of 34.5 (12.3) years, and a mean disease duration of 11.5 (7.4) years, their mean SLEDAI was 2.53 (3.7) and their mean SDI was 1.2 (1.5). Twenty-eight patients changed their activities at work due to SLE and 51 (26.6%) stopped working after their diagnosis; 21 of them (41.1%) stopped working because of SLE. One hundred and forty-three were working at the time of the evaluation. In the multivariate analyses, those work- disabled due to SLE were more likely to have higher SDI: OR=1.650 (CI95%: 1.134-2.403) p=0.009, and lower HRQoL in two domains, planning: OR=0.975 (CI 95%: 0.954-0.996) p=0.020 and body image OR=0.977 (CI95%: 0.956, 0.998), p=0.032.Conclusion: Work disability due to SLE is associated with higher damage accrual and a poorer HRQoL.

UR - http://www.mendeley.com/research/thu0648-work-disability-peruvian-cohort-systemic-lupus-erythematosus-patients

U2 - 10.1136/annrheumdis-2019-eular.6533

DO - 10.1136/annrheumdis-2019-eular.6533

M3 - Resumen de conferencia

JO - Annals of the Rheumatic Diseases

JF - Annals of the Rheumatic Diseases

ER -