TY - JOUR
T1 - The impact of indoor pollution on asthma-related outcomes
T2 - A systematic review for the EAACI guidelines on environmental science for allergic diseases and asthma
AU - Agache, Ioana
AU - Canelo-Aybar, Carlos
AU - Annesi-Maesano, Isabella
AU - Cecchi, Lorenzo
AU - Biagioni, Benedetta
AU - Chung, Fan
AU - D'Amato, Gennaro
AU - Damialis, Athanasios
AU - Del Giacco, Stefano
AU - De las Vecillas, Leticia
AU - Dominguez-Ortega, Javier
AU - Galàn, Carmen
AU - Gilles, Stefanie
AU - Giovannini, Mattia
AU - Holgate, Stephen
AU - Jeebhay, Mohamed
AU - Nadeau, Kari
AU - Papadopoulos, Nikolaos
AU - Quirce, Santiago
AU - Sastre, Joaquin
AU - Traidl-Hoffmann, Claudia
AU - Walusiak-Skorupa, Jolanta
AU - Sousa-Pinto, Bernardo
AU - Salazar, Josefina
AU - Rodríguez-Tanta, L. Yesenia
AU - Cantero, Yahveth
AU - Montesinos-Guevara, Camila
AU - Song, Yang
AU - Alvarado-Gamarra, Giancarlo
AU - Sola, Ivan
AU - Alonso-Coello, Pablo
AU - Nieto-Gutierrez, Wendy
AU - Jutel, Marek
AU - Akdis, Cezmi A.
N1 - Publisher Copyright:
© 2024 European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.
PY - 2024/7
Y1 - 2024/7
N2 - Systematic review using GRADE of the impact of exposure to volatile organic compounds (VOCs), cleaning agents, mould/damp, pesticides on the risk of (i) new-onset asthma (incidence) and (ii) adverse asthma-related outcomes (impact). MEDLINE, EMBASE and Web of Science were searched for indoor pollutant exposure studies reporting on new-onset asthma and critical and important asthma-related outcomes. Ninety four studies were included: 11 for VOCs (7 for incidenceand 4 for impact), 25 for cleaning agents (7 for incidenceand 8 for impact), 48 for damp/mould (26 for incidence and 22 for impact) and 10 for pesticides (8 for incidence and 2 for impact). Exposure to damp/mould increases the risk of new-onset wheeze (moderate certainty evidence). Exposure to cleaning agents may be associated with a higher risk of new-onset asthma and with asthma severity (low level of certainty). Exposure to pesticides and VOCs may increase the risk of new-onset asthma (very low certainty evidence). The impact on asthma-related outcomes of all major indoor pollutants is uncertain. As the level of certainty is low or very low for most of the available evidence on the impact of indoor pollutants on asthma-related outcomes more rigorous research in the field is warranted.
AB - Systematic review using GRADE of the impact of exposure to volatile organic compounds (VOCs), cleaning agents, mould/damp, pesticides on the risk of (i) new-onset asthma (incidence) and (ii) adverse asthma-related outcomes (impact). MEDLINE, EMBASE and Web of Science were searched for indoor pollutant exposure studies reporting on new-onset asthma and critical and important asthma-related outcomes. Ninety four studies were included: 11 for VOCs (7 for incidenceand 4 for impact), 25 for cleaning agents (7 for incidenceand 8 for impact), 48 for damp/mould (26 for incidence and 22 for impact) and 10 for pesticides (8 for incidence and 2 for impact). Exposure to damp/mould increases the risk of new-onset wheeze (moderate certainty evidence). Exposure to cleaning agents may be associated with a higher risk of new-onset asthma and with asthma severity (low level of certainty). Exposure to pesticides and VOCs may increase the risk of new-onset asthma (very low certainty evidence). The impact on asthma-related outcomes of all major indoor pollutants is uncertain. As the level of certainty is low or very low for most of the available evidence on the impact of indoor pollutants on asthma-related outcomes more rigorous research in the field is warranted.
KW - asthma
KW - GRADE
KW - guideline
KW - indoor pollution
KW - systematic review
UR - http://www.scopus.com/inward/record.url?scp=85185664806&partnerID=8YFLogxK
U2 - 10.1111/all.16051
DO - 10.1111/all.16051
M3 - Artículo de revisión
C2 - 38366695
AN - SCOPUS:85185664806
SN - 0105-4538
VL - 79
SP - 1761
EP - 1788
JO - Allergy: European Journal of Allergy and Clinical Immunology
JF - Allergy: European Journal of Allergy and Clinical Immunology
IS - 7
ER -
