Systematic review and meta-analysis of the effects of treatment modalities for vestibulodynia in women

Faustino R. Pérez-López, Juan Bueno-Notivol, Adrian V. Hernandez, Pedro Vieira-Baptista, Mario Preti, Jacob Bornstein

Resultado de la investigación: Contribución a una revistaArtículoInvestigaciónrevisión exhaustiva

Resumen

Objective: To quantify the effects of available treatments of vestibulodynia. Methods: Systematic review of randomised controlled trials (RCTs) in six search engines until December 2018, comparing any intervention vs. placebo or sham in women with vestibulodynia. Primary outcome was dyspareunia assessed with visual analogue (VAS) or numeric rating (NRS) scales. Secondary outcomes were daily vestibular symptoms (DVS), McGill Pain Questionnaire (MPQ) and Index of Sexual Satisfaction (ISS). Effects were described as mean differences (MDs) with their 95% confidence intervals (CIs). Traditional and frequentist network meta-analyses (NMA) were performed using random effect models. Results: Four RCTs (n = 275) were included evaluating vaginal cream of conjugated oestrogens, oral desipramine with or without topical lidocaine, topical lidocaine, laser therapy and transcranial direct current. In traditional MA, interventions did not reduce dyspareunia (MD = 0.08; 95%CI = −0.49 to 0.64), DVS (MD = −0.04; 95%CI = −0.31 to 0.24; 4 interventions), or MPQ (MD = −0.17; 95%CI = −2.16 to 1.81; 4 interventions). ISS was significantly improved (MD = −5.14; 95%CI = −9.52 to −0.75). In NMA, oral desipramine with or without lidocaine significantly improved ISS vs. other treatments. Conclusions: Several existing interventions were not associated with improvements in vestibulodynia. There only was improvement of sexual function with oral desipramine with or without lidocaine.

Huella dactilar

Vulvodynia
Meta-Analysis
Lidocaine
Orgasm
Desipramine
Confidence Intervals
Dyspareunia
Pain Measurement
Randomized Controlled Trials
Foams and Jellies Vaginal Creams
Therapeutics
Conjugated (USP) Estrogens
Search Engine
Laser Therapy
Placebos

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title = "Systematic review and meta-analysis of the effects of treatment modalities for vestibulodynia in women",
abstract = "Objective: To quantify the effects of available treatments of vestibulodynia. Methods: Systematic review of randomised controlled trials (RCTs) in six search engines until December 2018, comparing any intervention vs. placebo or sham in women with vestibulodynia. Primary outcome was dyspareunia assessed with visual analogue (VAS) or numeric rating (NRS) scales. Secondary outcomes were daily vestibular symptoms (DVS), McGill Pain Questionnaire (MPQ) and Index of Sexual Satisfaction (ISS). Effects were described as mean differences (MDs) with their 95{\%} confidence intervals (CIs). Traditional and frequentist network meta-analyses (NMA) were performed using random effect models. Results: Four RCTs (n = 275) were included evaluating vaginal cream of conjugated oestrogens, oral desipramine with or without topical lidocaine, topical lidocaine, laser therapy and transcranial direct current. In traditional MA, interventions did not reduce dyspareunia (MD = 0.08; 95{\%}CI = −0.49 to 0.64), DVS (MD = −0.04; 95{\%}CI = −0.31 to 0.24; 4 interventions), or MPQ (MD = −0.17; 95{\%}CI = −2.16 to 1.81; 4 interventions). ISS was significantly improved (MD = −5.14; 95{\%}CI = −9.52 to −0.75). In NMA, oral desipramine with or without lidocaine significantly improved ISS vs. other treatments. Conclusions: Several existing interventions were not associated with improvements in vestibulodynia. There only was improvement of sexual function with oral desipramine with or without lidocaine.",
keywords = "Dyspareunia, sexual function, vestibulodynia, vulvar pain, vulvodynia",
author = "P{\'e}rez-L{\'o}pez, {Faustino R.} and Juan Bueno-Notivol and Hernandez, {Adrian V.} and Pedro Vieira-Baptista and Mario Preti and Jacob Bornstein",
year = "2019",
month = "1",
day = "1",
doi = "10.1080/13625187.2019.1643835",
language = "Ingl{\'e}s",
journal = "European Journal of Contraception and Reproductive Health Care",
issn = "1362-5187",
publisher = "Taylor & Francis",

}

Systematic review and meta-analysis of the effects of treatment modalities for vestibulodynia in women. / Pérez-López, Faustino R.; Bueno-Notivol, Juan; Hernandez, Adrian V.; Vieira-Baptista, Pedro; Preti, Mario; Bornstein, Jacob.

En: European Journal of Contraception and Reproductive Health Care, 01.01.2019.

Resultado de la investigación: Contribución a una revistaArtículoInvestigaciónrevisión exhaustiva

TY - JOUR

T1 - Systematic review and meta-analysis of the effects of treatment modalities for vestibulodynia in women

AU - Pérez-López, Faustino R.

AU - Bueno-Notivol, Juan

AU - Hernandez, Adrian V.

AU - Vieira-Baptista, Pedro

AU - Preti, Mario

AU - Bornstein, Jacob

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Objective: To quantify the effects of available treatments of vestibulodynia. Methods: Systematic review of randomised controlled trials (RCTs) in six search engines until December 2018, comparing any intervention vs. placebo or sham in women with vestibulodynia. Primary outcome was dyspareunia assessed with visual analogue (VAS) or numeric rating (NRS) scales. Secondary outcomes were daily vestibular symptoms (DVS), McGill Pain Questionnaire (MPQ) and Index of Sexual Satisfaction (ISS). Effects were described as mean differences (MDs) with their 95% confidence intervals (CIs). Traditional and frequentist network meta-analyses (NMA) were performed using random effect models. Results: Four RCTs (n = 275) were included evaluating vaginal cream of conjugated oestrogens, oral desipramine with or without topical lidocaine, topical lidocaine, laser therapy and transcranial direct current. In traditional MA, interventions did not reduce dyspareunia (MD = 0.08; 95%CI = −0.49 to 0.64), DVS (MD = −0.04; 95%CI = −0.31 to 0.24; 4 interventions), or MPQ (MD = −0.17; 95%CI = −2.16 to 1.81; 4 interventions). ISS was significantly improved (MD = −5.14; 95%CI = −9.52 to −0.75). In NMA, oral desipramine with or without lidocaine significantly improved ISS vs. other treatments. Conclusions: Several existing interventions were not associated with improvements in vestibulodynia. There only was improvement of sexual function with oral desipramine with or without lidocaine.

AB - Objective: To quantify the effects of available treatments of vestibulodynia. Methods: Systematic review of randomised controlled trials (RCTs) in six search engines until December 2018, comparing any intervention vs. placebo or sham in women with vestibulodynia. Primary outcome was dyspareunia assessed with visual analogue (VAS) or numeric rating (NRS) scales. Secondary outcomes were daily vestibular symptoms (DVS), McGill Pain Questionnaire (MPQ) and Index of Sexual Satisfaction (ISS). Effects were described as mean differences (MDs) with their 95% confidence intervals (CIs). Traditional and frequentist network meta-analyses (NMA) were performed using random effect models. Results: Four RCTs (n = 275) were included evaluating vaginal cream of conjugated oestrogens, oral desipramine with or without topical lidocaine, topical lidocaine, laser therapy and transcranial direct current. In traditional MA, interventions did not reduce dyspareunia (MD = 0.08; 95%CI = −0.49 to 0.64), DVS (MD = −0.04; 95%CI = −0.31 to 0.24; 4 interventions), or MPQ (MD = −0.17; 95%CI = −2.16 to 1.81; 4 interventions). ISS was significantly improved (MD = −5.14; 95%CI = −9.52 to −0.75). In NMA, oral desipramine with or without lidocaine significantly improved ISS vs. other treatments. Conclusions: Several existing interventions were not associated with improvements in vestibulodynia. There only was improvement of sexual function with oral desipramine with or without lidocaine.

KW - Dyspareunia

KW - sexual function

KW - vestibulodynia

KW - vulvar pain

KW - vulvodynia

UR - http://www.scopus.com/inward/record.url?scp=85070312183&partnerID=8YFLogxK

U2 - 10.1080/13625187.2019.1643835

DO - 10.1080/13625187.2019.1643835

M3 - Artículo

JO - European Journal of Contraception and Reproductive Health Care

JF - European Journal of Contraception and Reproductive Health Care

SN - 1362-5187

ER -