Synergistic anti-inflammatory effect of NSAIDs plus B vitamins administered pre and postoperatively in third molar surgery: randomized clinical trial: ensaio clínico randomizado

Vanessa Roxana Pérez-Jimenez, Victor Manuel Chumpitaz-Cerrate, Lesly Karem Chávez-Rimache, David Erik Moreno-Villalobos, Arturo Alberto Rodríguez-Flores, Cesar Ivanovish Franco-Quino, Carlos Humberto Erazo-Paredes

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

Resumen

Objective: The aim of the present study was to evaluate the synergistic anti-inflammatory effect of Non-steroidal anti-inflammatory drugs (NSAIDs) plus B vitamins administered pre and postoperatively in surgeries of impacted mandibular third molars. Material and Methods: Double-blind randomized clinical trial, sixty-six patients participated and were randomized into 2 groups. The control group was administered meloxicam 15 mg intramuscularly plus placebo orally and to the experimental group, meloxicam 15 mg intramuscularly plus vitamins B [B1, B6, and B12] orally; both treatments were administered preoperatively. The anti-inflammatory effect was evaluated by pain intensity, facial swelling (facial contour measurements), and mouth opening (distance between the upper and lower incisors) during the post-surgical phase. Student’s t-test was performed for independent samples. Results: In all the evaluated times (1 hour, 6 hours, 12 hours, 24 hours, 2 days, and 3 days after the end of the surgery) the experimental group presented a significantly lower intensity of pain compared to the control group (p<0.05). The highest pain intensity was recorded at 6 hours (17.7 ± 9.1 mm in the experimental group and 34.5 ± 21.3 mm in the control group). Swelling and mouth opening were similar in both groups, at all times evaluated (p>0.05). Conclusion: In the present study, the administration of NSAIDs plus B vitamins (B1, B6, B12) produced lower intensity of pain compared to the administration of only NSAIDs. Nevertheless, swelling and mouth opening were similar in all evaluations for both study groups.

Título traducido de la contribuciónSynergistic anti-inflammatory effect of NSAIDs plus B vitamins administered pre and postoperatively in third molar surgery: randomized clinical trial
Idioma originalPortugués
Número de artículoe3441
PublicaciónBrazilian Dental Science
Volumen25
N.º4
DOI
EstadoPublicada - set. 2022
Publicado de forma externa

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