State of art of cancer pharmacogenomics in Latin American populations

Andrés López-Cortés, Santiago Guerrero, María Ana Redal, Angel Alvarado, Luis Abel Quiñones

Resultado de la investigación: Contribución a una revistaArtículo de revisiónrevisión exhaustiva

12 Citas (Scopus)

Resumen

Over the past decades, several studies have shown that tumor-related somatic and germline alterations predicts tumor prognosis, drug response and toxicity. Latin American populations present a vast geno-phenotypic diversity due to the great interethnic and interracial mixing. This genetic flow leads to the appearance of complex characteristics that allow individuals to adapt to endemic environments, such as high altitude or extreme tropical weather. These genetic changes, most of them subtle and unexplored, could establish a mutational profile to develop new pharmacogenomic therapies specific for Latin American populations. In this review, we present the current status of research on somatic and germline alterations in Latin America compared to those found in Caucasian and Asian populations.

Idioma originalInglés
Número de artículo639
PublicaciónInternational Journal of Molecular Sciences
Volumen18
N.º6
DOI
EstadoPublicada - jun 2017
Publicado de forma externa

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