Prevalence and incidence of diabetic peripheral neuropathy in Latin America and the Caribbean: A systematic review and metaanalysis

Marlon Yovera-Aldana, Victor Velasquez-Rimachi, Andrely Huerta-Rosario, M. D. More-Yupanqui, Mariela Osores-Flores, Ricardo Espinoza, Fradis Gil-Olivares, Cesar Quispe-Nolazco, Flor Quea-Velez, Cristian Morán-Mariños, Isabel Pinedo-Torres, Carlos Alva-Diaz, Kevin Pacheco-Barrios

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

Resumen

AIMS: The objective of this systematic review and meta-analysis is to estimate the prevalence and incidence of diabetic peripheral neuropathy (DPN) in Latin America and the Caribbean (LAC).

MATERIALS AND METHODS: We searched MEDLINE, SCOPUS, Web of Science, EMBASE and LILACS databases of published observational studies in LAC up to December 2020. Meta-analyses of proportions were performed using random-effects models using Stata Program 15.1. Heterogeneity was evaluated through sensitivity, subgroup, and meta-regression analyses. Evidence certainty was performed with the GRADE approach.

RESULTS: Twenty-nine studies from eight countries were included. The estimated prevalence of DPN was 46.5% (95%CI: 38.0-55.0) with a significant heterogeneity (I2 = 98.2%; p<0.01). Only two studies reported incidence, and the pooled effect size was 13.7% (95%CI: 10.6-17.2). We found an increasing trend of cumulative DPN prevalence over time. The main sources of heterogeneity associated with higher prevalence were diagnosis criteria, higher A1c (%), and inadequate sample size. We judge the included evidence as very low certainty.

CONCLUSION: The overall prevalence of DPN is high in LAC with significant heterogeneity between and within countries that could be explained by population type and methodological aspects. Significant gaps (e.g., under-representation of most countries, lack of incidence studies, and heterogenous case definition) were identified. Standardized and population-based studies of DPN in LAC are needed.

Idioma originalInglés
Número de artículoe0251642
Páginas (desde-hasta)e0251642
PublicaciónPLoS ONE
Volumen16
N.º5
DOI
EstadoPublicada - 1 may 2021
Publicado de forma externa

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