TY - JOUR
T1 - Perfil epidemiológico y molecular de pacientes con cáncer de pulmón en un centro oncológicoreferencialdeLima,Perú
AU - Motta-Guerrero, Rodrigo
AU - Huerta-Collado, Yesenia
AU - Failoc-Rojas, Virgilio E.
AU - Cabezas-Orellana, Diego C.
AU - Garrido-Lecca, Alejandro León
AU - Calle-Villavicencio, Ana
AU - Torres-Mera, Alicia
AU - Valladares-Garrido, Mario J.
AU - Macha, Carlos Aliaga
AU - Carracedo, Carlos
N1 - Publisher Copyright:
© 2023 Medical Body of the Almanzor Aguinaga Asenjo National Hospital. All rights reserved.
PY - 2023
Y1 - 2023
N2 - Background: According to GLOBOCAN estimates, in 2020, lung cancer was the second most frequent cancer and epidemiological information is needed in Latin American countries. The objective w a s t o d e s c r i b e t h e e p i d e m i o l o g i c a l a n d m o l e c u l a r characteristics of lung cancer patients from a referral clinic in Lima, Peru. Material and methods: A retrospective cohort study was conducted to characterize the epidemiological and molecular profile of lung cancer patients attended at a referral cancer center in Peru during 2018 to 2021. Variables such as age, sex, histology, staging and mutation were reported. In the descriptive analysis, frequencies and percentages were shown for categorical variables. For numerical variables, the best measure of central tendency and dispersion was reported. Results: A total of 225 patients with a diagnosis of lung cancer were observed. EGFR gene mutation was the most frequently detected (45.3%); and within them exon 19 deletion (55.7%). The most frequent histological type was adenocarcinoma with 180 patients (85.7%). Of the total number of patients with EGFR mutation, 77.8% received treatment with a tyrosine kinase inhibitor (osimertinib, erlotinib, afatinib) and 15.9% received immunotherapy (pembrolizumab, atezolizumab, nivolumab). Conclusions: The predominant mutation was EGFR, the most frequent histologic type was adenocarcinoma and most patients received treatment with a tyrosine kinase inhibitor.
AB - Background: According to GLOBOCAN estimates, in 2020, lung cancer was the second most frequent cancer and epidemiological information is needed in Latin American countries. The objective w a s t o d e s c r i b e t h e e p i d e m i o l o g i c a l a n d m o l e c u l a r characteristics of lung cancer patients from a referral clinic in Lima, Peru. Material and methods: A retrospective cohort study was conducted to characterize the epidemiological and molecular profile of lung cancer patients attended at a referral cancer center in Peru during 2018 to 2021. Variables such as age, sex, histology, staging and mutation were reported. In the descriptive analysis, frequencies and percentages were shown for categorical variables. For numerical variables, the best measure of central tendency and dispersion was reported. Results: A total of 225 patients with a diagnosis of lung cancer were observed. EGFR gene mutation was the most frequently detected (45.3%); and within them exon 19 deletion (55.7%). The most frequent histological type was adenocarcinoma with 180 patients (85.7%). Of the total number of patients with EGFR mutation, 77.8% received treatment with a tyrosine kinase inhibitor (osimertinib, erlotinib, afatinib) and 15.9% received immunotherapy (pembrolizumab, atezolizumab, nivolumab). Conclusions: The predominant mutation was EGFR, the most frequent histologic type was adenocarcinoma and most patients received treatment with a tyrosine kinase inhibitor.
KW - epidemiology
KW - lung neoplasia
KW - Mutation
KW - Peru. (Source: DeCS-BIREME)
UR - http://www.scopus.com/inward/record.url?scp=85185337087&partnerID=8YFLogxK
U2 - 10.35434/rcmhnaaa.2023.163.1805
DO - 10.35434/rcmhnaaa.2023.163.1805
M3 - Artículo
AN - SCOPUS:85185337087
SN - 2225-5109
VL - 16
JO - Revista del Cuerpo Medico Hospital Nacional Almanzor Aguinaga Asenjo
JF - Revista del Cuerpo Medico Hospital Nacional Almanzor Aguinaga Asenjo
IS - 3
ER -