TY - JOUR
T1 - Ophthalmic Manifestations of the Monkeypox Virus
T2 - A Systematic Review and Meta-Analysis
AU - Gandhi, Aravind P.
AU - Gupta, Parul Chawla
AU - Padhi, Bijaya K.
AU - Sandeep, Mokanpally
AU - Suvvari, Tarun Kumar
AU - Shamim, Muhammad Aaqib
AU - Satapathy, Prakasini
AU - Sah, Ranjit
AU - León-Figueroa, Darwin A.
AU - Rodriguez-Morales, Alfonso J.
AU - Barboza, Joshuan J.
AU - Dziedzic, Arkadiusz
N1 - Publisher Copyright:
© 2023 by the authors.
PY - 2023/3
Y1 - 2023/3
N2 - Background: The accurate estimation of the prevalence of mpox-induced ophthalmic lesions will enable health departments to allocate resources more effectively during the ongoing mpox pandemic. The aim of this meta-analysis was to estimate the global prevalence of ophthalmic manifestations in mpox patients. Methods: A systematic search was carried out in seven databases—Pub Med, Scopus, Web of Science, EMBASE, ProQuest, EBSCOHost, and Cochrane—for studies published on or before 12 December 2022. The pooled prevalence of ophthalmic manifestations was estimated by the random effects model. Risk of bias assessment of the studies and sub-group analysis to explain heterogeneity were undertaken. Results: Overall, 12 studies were included, with 3239 confirmed mpox cases, among which 755 patients reported ophthalmic manifestations. The pooled prevalence of ophthalmic manifestations was 9% (95% confidence interval (CI), 3–24). Studies from Europe reported a very low prevalence of ocular manifestations of 0.98% (95% CI 0.14–2.31), compared to studies from Africa with a substantially higher prevalence of 27.22% (95% CI 13.69–43.26). Conclusions: A wide variation in the prevalence of ocular manifestations among mpox patients was observed globally. Healthcare workers involved in mpox-endemic African countries should be aware of ocular manifestations for early detection and management.
AB - Background: The accurate estimation of the prevalence of mpox-induced ophthalmic lesions will enable health departments to allocate resources more effectively during the ongoing mpox pandemic. The aim of this meta-analysis was to estimate the global prevalence of ophthalmic manifestations in mpox patients. Methods: A systematic search was carried out in seven databases—Pub Med, Scopus, Web of Science, EMBASE, ProQuest, EBSCOHost, and Cochrane—for studies published on or before 12 December 2022. The pooled prevalence of ophthalmic manifestations was estimated by the random effects model. Risk of bias assessment of the studies and sub-group analysis to explain heterogeneity were undertaken. Results: Overall, 12 studies were included, with 3239 confirmed mpox cases, among which 755 patients reported ophthalmic manifestations. The pooled prevalence of ophthalmic manifestations was 9% (95% confidence interval (CI), 3–24). Studies from Europe reported a very low prevalence of ocular manifestations of 0.98% (95% CI 0.14–2.31), compared to studies from Africa with a substantially higher prevalence of 27.22% (95% CI 13.69–43.26). Conclusions: A wide variation in the prevalence of ocular manifestations among mpox patients was observed globally. Healthcare workers involved in mpox-endemic African countries should be aware of ocular manifestations for early detection and management.
KW - meta-analysis
KW - mpox
KW - ocular manifestations
KW - outbreaks
UR - http://www.scopus.com/inward/record.url?scp=85151144763&partnerID=8YFLogxK
U2 - 10.3390/pathogens12030452
DO - 10.3390/pathogens12030452
M3 - Artículo de revisión
AN - SCOPUS:85151144763
SN - 2076-0817
VL - 12
JO - Pathogens
JF - Pathogens
IS - 3
M1 - 452
ER -