Measuring Contralateral Silent Period Induced by Single-Pulse Transcranial Magnetic Stimulation to Investigate M1 Corticospinal Inhibition

Ingrid Rebello-Sanchez, Joao Parente, Kevin Pacheco-Barrios, Anna Marduy, Danielle Carolina Pimenta, Daniel Lima, Eric Slawka, Alejandra Cardenas-Rojas, Gleysson Rodrigues Rosa, Kamran Nazim, Abhishek Datta, Felipe Fregni

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

Resumen

Contralateral silent period (cSP) is a period of suppression in the background electrical muscle activity captured by electromyography (EMG) after a motor evoked potential (MEP). To obtain this, an MEP is elicited by a suprathreshold transcranial magnetic stimulation (TMS) pulse delivered to the primary motor cortex (M1) of the target muscle selected, while the participant provides a standardized voluntary target muscle contraction. The cSP is a result of inhibitory mechanisms that occur after the MEP; it provides a broad temporal assessment of spinal inhibition in its initial ~50 ms, and cortical inhibition after. Researchers have tried to better understand the neurobiological mechanism behind the cSP to validate it as a potential diagnostic, surrogate, and predictive biomarker for different neuropsychiatric diseases. Therefore, this article describes a method to measure M1 cSP of lower and upper limbs, including a selection of target muscle, electrode placement, coil positioning, method of measuring voluntary contraction stimulation, intensity setup, and data analysis to obtain a representative result. It has the educational objective of giving a visual guideline in performing a feasible, reliable, and reproducible cSP protocol for lower and upper limbs and discussing practical challenges of this technique.

Idioma originalInglés
PublicaciónJournal of Visualized Experiments
N.º186
DOI
EstadoPublicada - 23 ago. 2022
Publicado de forma externa

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