The term transsexuality continues to be hotly debated in the literature and for many has become a scientific void. We sought to analyze the scientific production on transsexuality in Scopus, 2010-2022. Under a retrospective descriptive design, 624 articles were studied. It was found that 85.58% were research articles. Brazil has more research on the subject (41.83%); institutions in Brazil, Peru and Argentina have the highest production, and AIDS and Behavior and Plos One are the journals with the largest publications. The authors belong to Brazilian and Peruvian institutions. Research on transsexuality is minimal, so further research is needed.