Interacciones farmacocinéticas de la azitromicina e implicación clínica

María Saravia Bartra, Ricardo Losno García, Milton Valderrama-Wong, Ana María Muñoz Jáuregui, María Bendezú Acevedo, Jorge García Ceccarelli, Felipe Surco Laos, Patricia Basurto Ayala, Mario Pineda-Pérez, Angel Tito Alvarado Yarasca

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

Resumen

Introduction: The severe acute respiratory syndrome (due to COVID-19) is currently the leading cause of death in Peru, so effective and safe drugs are required to mitigate the disease. A bibliographic search was carried out in SciELO and PubMed/Medline, 37 of 58 articles on the topic were selected. Objectives: Review and integrate the information on the pharmacokinetic interactions of azithromycin that are prescribed in the outpatient treatment of COVID-19 in Peru, and evaluate their clinical implication. Development: Azithromycin is used in COVID-19, due to its anti-inflammatory activity, by inhibiting interleukins (IL1, 6, 8 and TNF-α), and intracellular adhesion molecules 1 (ICAM1), and by inducing the production of type I interferon (IFN-α, IFN-β) and III (IFN-λ) in cells of patients with chronic obstructive pulmonary disease. The three-arm, randomized and open-label studies indicate that azithromycin does not cause changes in the pharmacokinetic parameters of ivermectin, sildenafil, rupatadine, and desloratadine, single-center, open-label, non-fasting, and two-period studies show that azithromycin influences the pharmacokinetic parameters of venetoclax and psychotropics. Conclusions: Based on the evidence from the reviewed and integrated clinical studies, it is concluded that these are limited and of little clinical relevance, however, it is proposed to use the antibiotic under the scientific criteria of the doctor, to avoid pharmacokinetic interactions and adverse reactions of drugs.

Título traducido de la contribuciónPharmacokinetic interactions of azithromycin and clinical implication
Idioma originalEspañol
Número de artículoe02101284
PublicaciónRevista Cubana de Medicina Militar
Volumen50
N.º3
EstadoPublicada - 1 jul 2021
Publicado de forma externa

Palabras clave

  • Azithromycin
  • Coronavirus infections
  • COVID-19
  • Drug interactions
  • Pharmacokinetics
  • SARS-CoV-2

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