Human papillomavirus vaccine efficacy in the prevention of anogenital warts: Systematic review and meta-analysis

Romina A. Tejada, Kris G. Vargas, Vicente Benites Zapata, Edward Mezones Holguin, Rafael Bolaños-Díaz, Adrian V. Hernández

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

11 Citas (Scopus)

Resumen

Objective. To review evidence on the efficacy of HPV vaccines in the prevention of non-cancer lesions (anogenital warts [AGW], recurrent laryngeal papillomatosis and oral papillomatosis). Materials and methods. We conducted a systematic review of randomized trials. We performed random effect models and effects were reported as relative risks (RR) and their confidence intervals (95%CI) following both intention to treat (ITT) and per protocol (PP) analyses. Results. We included six studies (n=27 078). One study was rated as high risk of bias. One study could not be included in the meta-analysis because it provided combined results. We found that quadrivalent vaccine reduced the risk of AGW by 62% (RR: 0.38, 95%CI:0.32-0.45, I2:0%) in the ITT analysis and by 95% (RR: 0.05, 95%CI:0.01-0.25, I2:66%) in the PP analysis. Subgroup analyses of studies in women or with low-risk of bias provided similar results. Conclusion. HPV quadrivalent vaccine is efficacious in preventing AGW in men and women.

Idioma originalInglés
Páginas (desde-hasta)84-94
Número de páginas11
PublicaciónSalud Publica de Mexico
Volumen59
N.º1
DOI
EstadoPublicada - 2017
Publicado de forma externa

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