High waist-to-hip ratio levels are associated with insulin resistance markers in normal-weight women

Vicente A. Benites-Zapata, Carlos J. Toro-Huamanchumo, Diego Urrunaga-Pastor, Mirella Guarnizo-Poma, Herbert Lazaro-Alcantara, Socorro Paico-Palacios, Betzi Pantoja-Torres, Vitalia del Carmen Ranilla-Seguin

Resultado de la investigación: Contribución a una revistaArtículoInvestigaciónrevisión exhaustiva

2 Citas (Scopus)

Resumen

Aim: To assess the association between high waist-to-hip ratio (WHR) levels and insulin resistance (IR) or hyperinsulinemia after oral glucose tolerance test (OGTT) in a sample of normal-weight women. Methods: We conducted an analytical cross-sectional study in euthyroid non-diabetic women, who attended the outpatient service of a private clinic in Lima-Peru from 2012 to 2016. Participants were divided in two groups according to the presence or absence of high WHR levels, IR or hyperinsulinemia after OGTT. We considered WHR values > 0.85 as high levels. IR was defined as a Homeostasis Model Assessment (HOMA-IR) value > 2.39 and hyperinsulinemia after OGTT as a serum insulin value ≥ 80μU/mL after 120 min of 75-g glucose intake. We elaborated crude and adjusted Poisson generalized linear models to evaluate the association between high WHR levels and IR or hyperinsulinemia after OGTT and reported the prevalence ratio (PR) with their respective 95% confidence intervals (95%CI). Results: We analyzed the data of 248 euthyroid, non-diabetic and normal-weight women. The prevalence of high WHR levels was 68.9% (n = 171) while the prevalence of IR and hyperinsulinemia after OGTT was 25% (n = 62) and 15.3% (n = 38), respectively. WHR values were positively correlated with HOMA-IR (r = 0.307; p < 0.001) and serum insulin after OGTT (r = 0.260; p < 0.001). In the adjusted model, high WHR levels were associated with both IR (aPR = 2.63; 95%CI: 1.39–5.01) and hyperinsulinemia after OGTT (aPR = 2.35; 95%CI: 1.03–5.38). Conclusion: High WHR levels were associated with both IR markers used in our study, appearing to be a useful anthropometric indicator to assess IR in euthyroid normal-weight women without type 2 diabetes mellitus.

Idioma originalInglés estadounidense
Páginas (desde-hasta)636-642
Número de páginas7
PublicaciónDiabetes and Metabolic Syndrome: Clinical Research and Reviews
Volumen13
N.º1
DOI
EstadoPublicada - 1 ene 2019

Huella dactilar

Waist-Hip Ratio
Insulin Resistance
Glucose Tolerance Test
Hyperinsulinism
Weights and Measures
Confidence Intervals
Insulin
Peru
Ambulatory Care
Serum
Type 2 Diabetes Mellitus
Linear Models
Homeostasis
Cross-Sectional Studies
Glucose

Citar esto

Benites-Zapata, Vicente A. ; Toro-Huamanchumo, Carlos J. ; Urrunaga-Pastor, Diego ; Guarnizo-Poma, Mirella ; Lazaro-Alcantara, Herbert ; Paico-Palacios, Socorro ; Pantoja-Torres, Betzi ; Ranilla-Seguin, Vitalia del Carmen. / High waist-to-hip ratio levels are associated with insulin resistance markers in normal-weight women. En: Diabetes and Metabolic Syndrome: Clinical Research and Reviews. 2019 ; Vol. 13, N.º 1. pp. 636-642.
@article{97c0cb5e122e4e588abe411f56cdc776,
title = "High waist-to-hip ratio levels are associated with insulin resistance markers in normal-weight women",
abstract = "Aim: To assess the association between high waist-to-hip ratio (WHR) levels and insulin resistance (IR) or hyperinsulinemia after oral glucose tolerance test (OGTT) in a sample of normal-weight women. Methods: We conducted an analytical cross-sectional study in euthyroid non-diabetic women, who attended the outpatient service of a private clinic in Lima-Peru from 2012 to 2016. Participants were divided in two groups according to the presence or absence of high WHR levels, IR or hyperinsulinemia after OGTT. We considered WHR values > 0.85 as high levels. IR was defined as a Homeostasis Model Assessment (HOMA-IR) value > 2.39 and hyperinsulinemia after OGTT as a serum insulin value ≥ 80μU/mL after 120 min of 75-g glucose intake. We elaborated crude and adjusted Poisson generalized linear models to evaluate the association between high WHR levels and IR or hyperinsulinemia after OGTT and reported the prevalence ratio (PR) with their respective 95{\%} confidence intervals (95{\%}CI). Results: We analyzed the data of 248 euthyroid, non-diabetic and normal-weight women. The prevalence of high WHR levels was 68.9{\%} (n = 171) while the prevalence of IR and hyperinsulinemia after OGTT was 25{\%} (n = 62) and 15.3{\%} (n = 38), respectively. WHR values were positively correlated with HOMA-IR (r = 0.307; p < 0.001) and serum insulin after OGTT (r = 0.260; p < 0.001). In the adjusted model, high WHR levels were associated with both IR (aPR = 2.63; 95{\%}CI: 1.39–5.01) and hyperinsulinemia after OGTT (aPR = 2.35; 95{\%}CI: 1.03–5.38). Conclusion: High WHR levels were associated with both IR markers used in our study, appearing to be a useful anthropometric indicator to assess IR in euthyroid normal-weight women without type 2 diabetes mellitus.",
keywords = "Diabetes mellitus, Glucose, Glucose tolerance test, Insulin resistance, Waist-hip ratio",
author = "Benites-Zapata, {Vicente A.} and Toro-Huamanchumo, {Carlos J.} and Diego Urrunaga-Pastor and Mirella Guarnizo-Poma and Herbert Lazaro-Alcantara and Socorro Paico-Palacios and Betzi Pantoja-Torres and Ranilla-Seguin, {Vitalia del Carmen}",
year = "2019",
month = "1",
day = "1",
doi = "10.1016/j.dsx.2018.11.043",
language = "American English",
volume = "13",
pages = "636--642",
journal = "Diabetes and Metabolic Syndrome: Clinical Research and Reviews",
issn = "1871-4021",
publisher = "Elsevier",
number = "1",

}

High waist-to-hip ratio levels are associated with insulin resistance markers in normal-weight women. / Benites-Zapata, Vicente A.; Toro-Huamanchumo, Carlos J.; Urrunaga-Pastor, Diego; Guarnizo-Poma, Mirella; Lazaro-Alcantara, Herbert; Paico-Palacios, Socorro; Pantoja-Torres, Betzi; Ranilla-Seguin, Vitalia del Carmen.

En: Diabetes and Metabolic Syndrome: Clinical Research and Reviews, Vol. 13, N.º 1, 01.01.2019, p. 636-642.

Resultado de la investigación: Contribución a una revistaArtículoInvestigaciónrevisión exhaustiva

TY - JOUR

T1 - High waist-to-hip ratio levels are associated with insulin resistance markers in normal-weight women

AU - Benites-Zapata, Vicente A.

AU - Toro-Huamanchumo, Carlos J.

AU - Urrunaga-Pastor, Diego

AU - Guarnizo-Poma, Mirella

AU - Lazaro-Alcantara, Herbert

AU - Paico-Palacios, Socorro

AU - Pantoja-Torres, Betzi

AU - Ranilla-Seguin, Vitalia del Carmen

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Aim: To assess the association between high waist-to-hip ratio (WHR) levels and insulin resistance (IR) or hyperinsulinemia after oral glucose tolerance test (OGTT) in a sample of normal-weight women. Methods: We conducted an analytical cross-sectional study in euthyroid non-diabetic women, who attended the outpatient service of a private clinic in Lima-Peru from 2012 to 2016. Participants were divided in two groups according to the presence or absence of high WHR levels, IR or hyperinsulinemia after OGTT. We considered WHR values > 0.85 as high levels. IR was defined as a Homeostasis Model Assessment (HOMA-IR) value > 2.39 and hyperinsulinemia after OGTT as a serum insulin value ≥ 80μU/mL after 120 min of 75-g glucose intake. We elaborated crude and adjusted Poisson generalized linear models to evaluate the association between high WHR levels and IR or hyperinsulinemia after OGTT and reported the prevalence ratio (PR) with their respective 95% confidence intervals (95%CI). Results: We analyzed the data of 248 euthyroid, non-diabetic and normal-weight women. The prevalence of high WHR levels was 68.9% (n = 171) while the prevalence of IR and hyperinsulinemia after OGTT was 25% (n = 62) and 15.3% (n = 38), respectively. WHR values were positively correlated with HOMA-IR (r = 0.307; p < 0.001) and serum insulin after OGTT (r = 0.260; p < 0.001). In the adjusted model, high WHR levels were associated with both IR (aPR = 2.63; 95%CI: 1.39–5.01) and hyperinsulinemia after OGTT (aPR = 2.35; 95%CI: 1.03–5.38). Conclusion: High WHR levels were associated with both IR markers used in our study, appearing to be a useful anthropometric indicator to assess IR in euthyroid normal-weight women without type 2 diabetes mellitus.

AB - Aim: To assess the association between high waist-to-hip ratio (WHR) levels and insulin resistance (IR) or hyperinsulinemia after oral glucose tolerance test (OGTT) in a sample of normal-weight women. Methods: We conducted an analytical cross-sectional study in euthyroid non-diabetic women, who attended the outpatient service of a private clinic in Lima-Peru from 2012 to 2016. Participants were divided in two groups according to the presence or absence of high WHR levels, IR or hyperinsulinemia after OGTT. We considered WHR values > 0.85 as high levels. IR was defined as a Homeostasis Model Assessment (HOMA-IR) value > 2.39 and hyperinsulinemia after OGTT as a serum insulin value ≥ 80μU/mL after 120 min of 75-g glucose intake. We elaborated crude and adjusted Poisson generalized linear models to evaluate the association between high WHR levels and IR or hyperinsulinemia after OGTT and reported the prevalence ratio (PR) with their respective 95% confidence intervals (95%CI). Results: We analyzed the data of 248 euthyroid, non-diabetic and normal-weight women. The prevalence of high WHR levels was 68.9% (n = 171) while the prevalence of IR and hyperinsulinemia after OGTT was 25% (n = 62) and 15.3% (n = 38), respectively. WHR values were positively correlated with HOMA-IR (r = 0.307; p < 0.001) and serum insulin after OGTT (r = 0.260; p < 0.001). In the adjusted model, high WHR levels were associated with both IR (aPR = 2.63; 95%CI: 1.39–5.01) and hyperinsulinemia after OGTT (aPR = 2.35; 95%CI: 1.03–5.38). Conclusion: High WHR levels were associated with both IR markers used in our study, appearing to be a useful anthropometric indicator to assess IR in euthyroid normal-weight women without type 2 diabetes mellitus.

KW - Diabetes mellitus

KW - Glucose

KW - Glucose tolerance test

KW - Insulin resistance

KW - Waist-hip ratio

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85056778587&origin=inward

UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85056778587&origin=inward

UR - http://www.mendeley.com/research/high-waisttohip-ratio-levels-associated-insulin-resistance-markers-normalweight-women

U2 - 10.1016/j.dsx.2018.11.043

DO - 10.1016/j.dsx.2018.11.043

M3 - Article

VL - 13

SP - 636

EP - 642

JO - Diabetes and Metabolic Syndrome: Clinical Research and Reviews

JF - Diabetes and Metabolic Syndrome: Clinical Research and Reviews

SN - 1871-4021

IS - 1

ER -