High triglycerides to HDL-cholesterol ratio is associated with insulin resistance in normal-weight healthy adults

Betzi Pantoja-Torres, Carlos J. Toro-Huamanchumo, Diego Urrunaga-Pastor, Mirella Guarnizo-Poma, Herbert Lazaro-Alcantara, Socorro Paico-Palacios, Vitalia del Carmen Ranilla-Seguin, Vicente A. Benites-Zapata

Resultado de la investigación: Contribución a una revistaArtículoInvestigaciónrevisión exhaustiva

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Resumen

© 2018 Diabetes India Aim: To evaluate the association between high triglyceride/HDL-cholesterol (TG/HDL-C) ratio and insulin resistance (IR) or hyperinsulinemia after oral glucose tolerance test (OGTT) in normal-weight healthy adults. Methods: We carried out an analytical cross-sectional study in euthyroid non-diabetic adults, who attended the outpatient service of a private clinic in Lima-Peru from 2012 to 2016. Participants were divided in two groups according to the presence or absence of high TG/HDL-C ratio, IR or hyperinsulinemia after OGTT. TG/HDL-C ratio values ≥ 3 were considered as high. IR was defined as a Homeostasis Model Assessment (HOMA-IR) value ≥ 2.28 and hyperinsulinemia after OGTT as a serum insulin value ≥ 80μU/mL after 120 min of 75-g glucose intake. We elaborated crude and adjusted Poisson generalized linear models to evaluate the association between high TG/HDL-C ratio and IR or hyperinsulinemia after OGTT and reported the prevalence ratio (PR) with their respective 95% confidence intervals (95%CI). Results: We analyzed the data of 118 individuals. Prevalence of high TG/HDL-C ratio was 17.8% (n = 21) while the prevalence of IR and hyperinsulinemia after OGTT was 24.6% (n = 29) and 17.0% (n = 20), respectively. TG/HDL-C-ratio values were positively correlated with HOMA-IR (r = 0.498; p < 0.01) and serum insulin after OGTT (r = 0.326; p < 0.001). In the adjusted model, high TG/HDL-C ratio was associated with both IR (aPR = 3.16; 95%CI: 1.80–5.77) and hyperinsulinemia after OGTT (aPR = 2.36; 95%CI: 1.20–4.63). Conclusions: High TG/HDL-C ratio was associated with both IR markers used in our study, appearing to be a clinically useful tool to assess IR in euthyroid normal-weight adults without type 2 diabetes mellitus.
Idioma originalInglés estadounidense
Páginas (desde-hasta)382-388
Número de páginas7
PublicaciónDiabetes and Metabolic Syndrome: Clinical Research and Reviews
DOI
EstadoPublicada - 1 ene 2019

Huella dactilar

HDL Cholesterol
Insulin Resistance
Triglycerides
Glucose Tolerance Test
Hyperinsulinism
Weights and Measures
Confidence Intervals
Insulin
Peru
Ambulatory Care
Serum
Type 2 Diabetes Mellitus
India
Linear Models
Homeostasis
Cross-Sectional Studies
Glucose

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@article{8464159e98dd4adb899ba1e2bd99f6ae,
title = "High triglycerides to HDL-cholesterol ratio is associated with insulin resistance in normal-weight healthy adults",
abstract = "{\circledC} 2018 Diabetes India Aim: To evaluate the association between high triglyceride/HDL-cholesterol (TG/HDL-C) ratio and insulin resistance (IR) or hyperinsulinemia after oral glucose tolerance test (OGTT) in normal-weight healthy adults. Methods: We carried out an analytical cross-sectional study in euthyroid non-diabetic adults, who attended the outpatient service of a private clinic in Lima-Peru from 2012 to 2016. Participants were divided in two groups according to the presence or absence of high TG/HDL-C ratio, IR or hyperinsulinemia after OGTT. TG/HDL-C ratio values ≥ 3 were considered as high. IR was defined as a Homeostasis Model Assessment (HOMA-IR) value ≥ 2.28 and hyperinsulinemia after OGTT as a serum insulin value ≥ 80μU/mL after 120 min of 75-g glucose intake. We elaborated crude and adjusted Poisson generalized linear models to evaluate the association between high TG/HDL-C ratio and IR or hyperinsulinemia after OGTT and reported the prevalence ratio (PR) with their respective 95{\%} confidence intervals (95{\%}CI). Results: We analyzed the data of 118 individuals. Prevalence of high TG/HDL-C ratio was 17.8{\%} (n = 21) while the prevalence of IR and hyperinsulinemia after OGTT was 24.6{\%} (n = 29) and 17.0{\%} (n = 20), respectively. TG/HDL-C-ratio values were positively correlated with HOMA-IR (r = 0.498; p < 0.01) and serum insulin after OGTT (r = 0.326; p < 0.001). In the adjusted model, high TG/HDL-C ratio was associated with both IR (aPR = 3.16; 95{\%}CI: 1.80–5.77) and hyperinsulinemia after OGTT (aPR = 2.36; 95{\%}CI: 1.20–4.63). Conclusions: High TG/HDL-C ratio was associated with both IR markers used in our study, appearing to be a clinically useful tool to assess IR in euthyroid normal-weight adults without type 2 diabetes mellitus.",
author = "Betzi Pantoja-Torres and Toro-Huamanchumo, {Carlos J.} and Diego Urrunaga-Pastor and Mirella Guarnizo-Poma and Herbert Lazaro-Alcantara and Socorro Paico-Palacios and {del Carmen Ranilla-Seguin}, Vitalia and Benites-Zapata, {Vicente A.}",
year = "2019",
month = "1",
day = "1",
doi = "10.1016/j.dsx.2018.10.006",
language = "American English",
pages = "382--388",
journal = "Diabetes and Metabolic Syndrome: Clinical Research and Reviews",
issn = "1871-4021",
publisher = "Elsevier",

}

High triglycerides to HDL-cholesterol ratio is associated with insulin resistance in normal-weight healthy adults. / Pantoja-Torres, Betzi; Toro-Huamanchumo, Carlos J.; Urrunaga-Pastor, Diego; Guarnizo-Poma, Mirella; Lazaro-Alcantara, Herbert; Paico-Palacios, Socorro; del Carmen Ranilla-Seguin, Vitalia; Benites-Zapata, Vicente A.

En: Diabetes and Metabolic Syndrome: Clinical Research and Reviews, 01.01.2019, p. 382-388.

Resultado de la investigación: Contribución a una revistaArtículoInvestigaciónrevisión exhaustiva

TY - JOUR

T1 - High triglycerides to HDL-cholesterol ratio is associated with insulin resistance in normal-weight healthy adults

AU - Pantoja-Torres, Betzi

AU - Toro-Huamanchumo, Carlos J.

AU - Urrunaga-Pastor, Diego

AU - Guarnizo-Poma, Mirella

AU - Lazaro-Alcantara, Herbert

AU - Paico-Palacios, Socorro

AU - del Carmen Ranilla-Seguin, Vitalia

AU - Benites-Zapata, Vicente A.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - © 2018 Diabetes India Aim: To evaluate the association between high triglyceride/HDL-cholesterol (TG/HDL-C) ratio and insulin resistance (IR) or hyperinsulinemia after oral glucose tolerance test (OGTT) in normal-weight healthy adults. Methods: We carried out an analytical cross-sectional study in euthyroid non-diabetic adults, who attended the outpatient service of a private clinic in Lima-Peru from 2012 to 2016. Participants were divided in two groups according to the presence or absence of high TG/HDL-C ratio, IR or hyperinsulinemia after OGTT. TG/HDL-C ratio values ≥ 3 were considered as high. IR was defined as a Homeostasis Model Assessment (HOMA-IR) value ≥ 2.28 and hyperinsulinemia after OGTT as a serum insulin value ≥ 80μU/mL after 120 min of 75-g glucose intake. We elaborated crude and adjusted Poisson generalized linear models to evaluate the association between high TG/HDL-C ratio and IR or hyperinsulinemia after OGTT and reported the prevalence ratio (PR) with their respective 95% confidence intervals (95%CI). Results: We analyzed the data of 118 individuals. Prevalence of high TG/HDL-C ratio was 17.8% (n = 21) while the prevalence of IR and hyperinsulinemia after OGTT was 24.6% (n = 29) and 17.0% (n = 20), respectively. TG/HDL-C-ratio values were positively correlated with HOMA-IR (r = 0.498; p < 0.01) and serum insulin after OGTT (r = 0.326; p < 0.001). In the adjusted model, high TG/HDL-C ratio was associated with both IR (aPR = 3.16; 95%CI: 1.80–5.77) and hyperinsulinemia after OGTT (aPR = 2.36; 95%CI: 1.20–4.63). Conclusions: High TG/HDL-C ratio was associated with both IR markers used in our study, appearing to be a clinically useful tool to assess IR in euthyroid normal-weight adults without type 2 diabetes mellitus.

AB - © 2018 Diabetes India Aim: To evaluate the association between high triglyceride/HDL-cholesterol (TG/HDL-C) ratio and insulin resistance (IR) or hyperinsulinemia after oral glucose tolerance test (OGTT) in normal-weight healthy adults. Methods: We carried out an analytical cross-sectional study in euthyroid non-diabetic adults, who attended the outpatient service of a private clinic in Lima-Peru from 2012 to 2016. Participants were divided in two groups according to the presence or absence of high TG/HDL-C ratio, IR or hyperinsulinemia after OGTT. TG/HDL-C ratio values ≥ 3 were considered as high. IR was defined as a Homeostasis Model Assessment (HOMA-IR) value ≥ 2.28 and hyperinsulinemia after OGTT as a serum insulin value ≥ 80μU/mL after 120 min of 75-g glucose intake. We elaborated crude and adjusted Poisson generalized linear models to evaluate the association between high TG/HDL-C ratio and IR or hyperinsulinemia after OGTT and reported the prevalence ratio (PR) with their respective 95% confidence intervals (95%CI). Results: We analyzed the data of 118 individuals. Prevalence of high TG/HDL-C ratio was 17.8% (n = 21) while the prevalence of IR and hyperinsulinemia after OGTT was 24.6% (n = 29) and 17.0% (n = 20), respectively. TG/HDL-C-ratio values were positively correlated with HOMA-IR (r = 0.498; p < 0.01) and serum insulin after OGTT (r = 0.326; p < 0.001). In the adjusted model, high TG/HDL-C ratio was associated with both IR (aPR = 3.16; 95%CI: 1.80–5.77) and hyperinsulinemia after OGTT (aPR = 2.36; 95%CI: 1.20–4.63). Conclusions: High TG/HDL-C ratio was associated with both IR markers used in our study, appearing to be a clinically useful tool to assess IR in euthyroid normal-weight adults without type 2 diabetes mellitus.

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U2 - 10.1016/j.dsx.2018.10.006

DO - 10.1016/j.dsx.2018.10.006

M3 - Article

SP - 382

EP - 388

JO - Diabetes and Metabolic Syndrome: Clinical Research and Reviews

JF - Diabetes and Metabolic Syndrome: Clinical Research and Reviews

SN - 1871-4021

ER -