TY - JOUR
T1 - Guía de práctica clínica para el tratamiento del cáncer de próstata metastásico hormonosensible en el Seguro Social del Perú (EsSalud)
AU - Cuevas-Muñoz, Nelson
AU - Broncano-Huasasquiche, Oswaldo
AU - Goicochea-Lugo, Sergio
AU - Delgado-Flores, Carolina J.
AU - Taype-Rondan, Alvaro
AU - Fernandez-Quiroz, Eliana L.
AU - Yberico, Teofilo Livano
AU - Cuentas-Jara, Mariano
AU - Cordier-Mariaca, Abel
AU - Velarde-Ponce, Luís Alberto
AU - Delgado-Iriarte, Jesús
AU - Santos-Sánchez, Vladimir
AU - Salvador-Salvador, Stefany
N1 - Publisher Copyright:
© 2023 Publicado por Cuerpo Médico Hospital Nacional Almanzor Aguinaga Asenjo.
PY - 2023
Y1 - 2023
N2 - Introduction: This article summarizes the clinical practice guideline (CPG) for the treatment of metastatic hormone-sensitive prostate cancer in the Social Security of Peru (EsSalud). Objective: To provide evidence-based clinical recommendations for the treatment of adults with hormone-sensitive metastatic adenocarcinoma of the prostate with de novo or recurrent presentation and high or low metastatic volume in EsSalud. Methods: A guideline development group (GDG) was formed, which included specialist physicians and methodologists, who formulated clinical questions. Systematic searches were conducted for systematic reviews and - when deemed relevant - primary studies in PubMed during 2022. Evidence was selected to answer each of the clinical questions posed. The certainty of evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology. In periodic working meetings, the GEG used the GRADE methodology to review the evidence and formulate recommendations. The CPG was reviewed by external experts before its approval. Results: The CPG addressed 6 clinical questions, divided into 2 main topics: considerations on androgen deprivation therapy (ADT) and ADT combined with other therapies. Based on these questions, 10 recommendations were formulated (4 strong and 6 conditional), and 6 points of good clinical practice. Conclusion: Evidence-based recommendations were issued for the management of patients with this pathology.
AB - Introduction: This article summarizes the clinical practice guideline (CPG) for the treatment of metastatic hormone-sensitive prostate cancer in the Social Security of Peru (EsSalud). Objective: To provide evidence-based clinical recommendations for the treatment of adults with hormone-sensitive metastatic adenocarcinoma of the prostate with de novo or recurrent presentation and high or low metastatic volume in EsSalud. Methods: A guideline development group (GDG) was formed, which included specialist physicians and methodologists, who formulated clinical questions. Systematic searches were conducted for systematic reviews and - when deemed relevant - primary studies in PubMed during 2022. Evidence was selected to answer each of the clinical questions posed. The certainty of evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology. In periodic working meetings, the GEG used the GRADE methodology to review the evidence and formulate recommendations. The CPG was reviewed by external experts before its approval. Results: The CPG addressed 6 clinical questions, divided into 2 main topics: considerations on androgen deprivation therapy (ADT) and ADT combined with other therapies. Based on these questions, 10 recommendations were formulated (4 strong and 6 conditional), and 6 points of good clinical practice. Conclusion: Evidence-based recommendations were issued for the management of patients with this pathology.
KW - Evidence-Based Medicine. (MeSH – NLM)
KW - GRADE Approach
KW - Neoplasm Metastasis
KW - Practice Guidelines as Topic
KW - Prostatic Neoplasms
UR - http://www.scopus.com/inward/record.url?scp=85185171238&partnerID=8YFLogxK
U2 - 10.35434/rcmhnaaa.2023.164.2049
DO - 10.35434/rcmhnaaa.2023.164.2049
M3 - Artículo
AN - SCOPUS:85185171238
SN - 2225-5109
VL - 16
JO - Revista del Cuerpo Medico Hospital Nacional Almanzor Aguinaga Asenjo
JF - Revista del Cuerpo Medico Hospital Nacional Almanzor Aguinaga Asenjo
IS - 4
ER -