Factors associated with pain pressure threshold in both local and remote sites in knee osteoarthritis

Marta Imamura, Ingrid Rebello-Sanchez, Joao Parente, Anna Marduy, Karen Vasquez-Avila, Kevin Pacheco-Barrios, Luis Castelo-Branco, Marcel Simis, Linamara Battistella, Felipe Fregni*

*Autor correspondiente de este trabajo

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

Resumen

Background: Knee osteoarthritis (KOA) is a prevalent condition, and its most frequent symptom is pain that often leads to disability. Pain sensitization is a core feature of KOA, and it can be measured through quantitative sensory testing protocols such as pain pressure threshold (PPT). However, there is a lack of understanding about the factors that may influence changes in PPTs in the KOA population. Objective: To explore the clinical and functional factors associated with PPTs in a sample of people with chronic KOA pain and to compare models of local (knees) and remote (thenar regions) sites. Design: Cross-sectional analysis of a prospective cohort. Setting: Primary care in public institution. Participants: 113 adults with KOA. Intervention: N/A. Main Outcome Measures: Multivariable regression analyses evaluating demographic, clinical, and functional variables that could be associated with local and remote PPTs (main outcomes) were performed. Results: Both thenar region (adjusted-R2: 0.29) and knee (adjusted-R2: 0.45) models had the same significant negative association with being a female, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain levels (thenar: β: −0.15, p =.002; knee: β: −0.2, p <.001), and the 10-Meter Walking Test (thenar: β: −0.05, p =.038; knee: β: −0.08, p =.004). A small significant positive association with depressive symptoms was identified in both models, which acted as a confounder for WOMAC pain and was likely affected by unmeasured confounders. Conclusions: PPTs in KOA pain are associated with functional outcomes such as the 10-Meter Walking Test and activity-related pain intensity; thus more disability is associated with smaller pain thresholds. Similarity between models may suggest central sensitization.

Idioma originalInglés
PublicaciónPM and R
DOI
EstadoPublicada - 2023

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