Evaluación broncodilatadora in vivo del extracto etanólico de los tallos de Jatropha macrantha Müll.Arg.

Haydee Chávez, Freddy Palomino, Jackeline Angelino, Ernesto Torres, María R. Bendezú, Jorge A. García, Berta Loja, Ana M. Muñoz, Angel T. Alvarado

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

Resumen

Context: Asthma is characterized by hyperresponsiveness and bronchoconstriction, induced by histamine and other noxes, with a prevalence in Peru of 20.7-28.2%, which is why, in traditional medicine, Jatropha macrantha Müll.Arg is used. Aims: To evaluate the in vivo bronchodilator activity of the ethanolic extract of the stems of J. macrantha. Methods: The powdered material of the stem of J. macrantha was extracted with ethanol 96° by maceration; then, the phytochemical screening was carried out. The doses of 200, 400 and 800 mg/kg of the extracts were subjected to in vivo evaluation in guinea pigs (Cavia porcellus) with 1% histamine-induced bronchoconstriction, determining the latency period and the intensity of the effect. Results: Phytochemical sieving showed alkaloids, catechins, flavonoids, tannins and terpenes. The activity was observed at the three doses of the J. macrantha extract, being higher at a single dose of 400 mg/kg, with a latency period of 33.0 ± 1.02 s, asphyxia 84.5 ± 1.08 s and anaphylaxis 105.6 ± 0.59 s. The analysis of variance and Dunnett's test resulted with p<0.05 as statistically significant. Conclusions: The results showed bronchodilator activity of the ethanolic extract of J. macrantha at an average dose of 400 mg/kg, orally, in Cavia porcellus.

Título traducido de la contribuciónIn vivobronchodilator evaluation of the ethanolic extract of the stems of Jatropha macranthaMüll.Arg.
Idioma originalEspañol
Páginas (desde-hasta)937-946
Número de páginas10
PublicaciónJournal of Pharmacy and Pharmacognosy Research
Volumen9
N.º6
EstadoPublicada - nov 2021

Palabras clave

  • Bronchodilator activity
  • Huanarpo female
  • Jatropha macrantha

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