TY - JOUR
T1 - Electroencephalography Signatures for Conditioned Pain Modulation and Pain Perception in Nonspecific Chronic Low Back Pain - An Exploratory Study
AU - Teixeira, Paulo E.P.
AU - Pacheco-Barrios, Kevin
AU - Uygur-Kucukseymen, Elif
AU - Machado, Roberto Mathias
AU - Balbuena-Pareja, Ana
AU - Giannoni-Luza, Stefano
AU - Luna-Cuadros, Maria Alejandra
AU - Cardenas-Rojas, Alejandra
AU - Gonzalez-Mego, Paola
AU - Mejia-Pando, Piero F.
AU - Wagner, Timothy
AU - Dipietro, Laura
AU - Fregni, Felipe
N1 - Publisher Copyright:
© 2021 The Author(s). Published by Oxford University Press on behalf of the American Academy of Pain Medicine. All rights reserved.
PY - 2022/3/1
Y1 - 2022/3/1
N2 - Conditioned pain modulation (CPM) can discriminate between healthy and chronic pain patients. However, its relationship with neurophysiological pain mechanisms is poorly understood. Brain oscillations measured by electroencephalography (EEG) might help gain insight into this complex relationship. Objective: To investigate the relationship between CPM response and self-reported pain intensity in non-specific chronic low back pain (NSCLBP) and explore respective EEG signatures associated to these mechanisms. Design: Cross-sectional analysis. Participants: Thirty NSCLBP patients participated. Methods: Self-reported low back pain, questionnaires, mood scales, CPM (static and dynamic quantitative sensory tests), and resting surface EEG data were collected and analyzed. Linear regression models were used for statistical analysis. Results: CPM was not significantly correlated with self-reported pain intensity scores. Relative power of EEG in the beta and high beta bands as recorded from the frontal, central, and parietal cortical areas were significantly associated with CPM. EEG relative power at delta and theta bands as recorded from the central area were significantly correlated with self-reported pain intensity scores while controlling for self-reported depression. Conclusions: Faster EEG frequencies recorded from pain perception areas may provide a signature of a potential cortical compensation caused by chronic pain states. Slower EEG frequencies may have a critical role in abnormal pain processing.
AB - Conditioned pain modulation (CPM) can discriminate between healthy and chronic pain patients. However, its relationship with neurophysiological pain mechanisms is poorly understood. Brain oscillations measured by electroencephalography (EEG) might help gain insight into this complex relationship. Objective: To investigate the relationship between CPM response and self-reported pain intensity in non-specific chronic low back pain (NSCLBP) and explore respective EEG signatures associated to these mechanisms. Design: Cross-sectional analysis. Participants: Thirty NSCLBP patients participated. Methods: Self-reported low back pain, questionnaires, mood scales, CPM (static and dynamic quantitative sensory tests), and resting surface EEG data were collected and analyzed. Linear regression models were used for statistical analysis. Results: CPM was not significantly correlated with self-reported pain intensity scores. Relative power of EEG in the beta and high beta bands as recorded from the frontal, central, and parietal cortical areas were significantly associated with CPM. EEG relative power at delta and theta bands as recorded from the central area were significantly correlated with self-reported pain intensity scores while controlling for self-reported depression. Conclusions: Faster EEG frequencies recorded from pain perception areas may provide a signature of a potential cortical compensation caused by chronic pain states. Slower EEG frequencies may have a critical role in abnormal pain processing.
KW - Chronic Low Back Pain
KW - Chronic Pain
KW - Conditioned Pain Modulation
KW - EEG Signature
KW - Pain Perception
KW - Pain Threshold/physiology
KW - Cross-Sectional Studies
KW - Humans
KW - Electroencephalography
KW - Low Back Pain/diagnosis
KW - Pain Perception/physiology
UR - http://www.scopus.com/inward/record.url?scp=85125552605&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/ec36da31-fe8d-3cdd-b4e1-261551924629/
U2 - 10.1093/pm/pnab293
DO - 10.1093/pm/pnab293
M3 - Artículo
C2 - 34633449
AN - SCOPUS:85125552605
SN - 1526-2375
VL - 23
SP - 558
EP - 570
JO - Pain Medicine
JF - Pain Medicine
IS - 3
ER -