Efecto sobre la motilidad intestinal del extracto de alcaloides de semilla de Jatropha curcas L

José María Carrasco Rueda, Armando Fartolino Guerrero, Ángela Sánchez Chávez, Junior Lujan Reyes, Alessandra Pachas Quiroz, Lucía del Carmen Castilla Candela, Rodrigo Núñez Bravo, Karen Osorio Giraldi, Angel Alvarado, C. Berta Loja Herrera, Alberto Salazar Granara

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

3 Citas (Scopus)

Resumen

Introduction: preclinical research studies of Jatropha curcas L. (piñón blanco) root extract proved its antidiarrheal activity; however the chronic toxicity test of the total seed extract demonstrated diarrheal effect. Objectives: to determine the effect of the alkaloid extract from Jatropha curcas L. seeds on the gastrointestinal motility. Methods: fifty albino mice with average weight of 25 g were used. The Arbos et al. ́s method was applied. The intestinal marker was 5 % activated charcoal administered at a dose of 0.1 mL/10 g. The experimental groups included 0.1 mL/10 g of distilled water, 1.5 mg/kg of atropine, alkaloid extract of Jatropha curcas L. seeds at doses of 500 and 1 000 mg/kg respectively, and 1 g/kg of neostigmine The statistical validation was based on Kruskal-Wallis test, ANOVA, and Tukey and Newman-Keuls test. Results: the percentages of the charcoal run were 69.21, 36.37, 58.96, 49.65, and 74.17 respectively. The ANOVA test demonstrated statistical significance (p< 0.05, IC 95 %). Comparative Tukey and Newman-Keuls test showed statistical significance between distilled water and Jatropha curcas at a dose of 1 000 mg/kg. Conclusions: the decrease on the gastrointestinal motility resulting from the effect of the alkaloid extract of Jatropha curcas seeds was proved at a dose of 1 000 mg/kg.

Título traducido de la contribuciónEffect of the alkaloid extract from Jatropha curcas L. seeds on the intestinal motility
Idioma originalEspañol
Páginas (desde-hasta)84-91
Número de páginas8
PublicaciónRevista Cubana de Plantas Medicinales
Volumen18
N.º1
EstadoPublicada - 2013
Publicado de forma externa

Palabras clave

  • Alkaloid
  • Intestinal motility
  • Jatropha curcas L.

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