Distribution of alpha-neoendorphin, ACTH (18–39) and beta-endorphin (1–27) in the alpaca brainstem

Manuel L. Sánchez, Eliana de Souza, Luis A. Aguilar, Rafael Coveñas

Resultado de la investigación: Contribución a una revistaArtículoInvestigaciónrevisión exhaustiva

Resumen

Using an immunocytochemical technique, we have studied in the alpaca brainstem the distribution of immunoreactive structures containing prodynorphin (alpha-neoendorphin)- and pro-opiomelanocortin (adrenocorticotrophin hormone (18–39) (ACTH), beta-endorphin (1–27))-derived peptides. No peptidergic-immunoreactive cell body was observed. Immunoreactive fibres were widely distributed, although in most of the brainstem nuclei the density of the peptidergic fibres was low or very low. In general, the distribution of the immunoreactive fibres containing the peptides studied was very similar. A close anatomical relationship occurred among the fibres containing alpha-neoendorphin, ACTH or beta-endorphin (1–27), suggesting a functional interaction among the three peptides in many of the brainstem nuclei. The number of fibres belonging to the prodynorphin system was higher than that of the pro-opiomelanocortin system. A moderate/low density of immunoreactive fibres was observed in 65.11% (for alpha-neoendorphin (1–27)), 18.18% (for ACTH) and 13.95% (for beta-endorphin) of the brainstem nuclei/tracts. In the alpaca brainstem, a high density of immunoreactive fibres was not observed. The neuroanatomical distribution of the immunoreactive fibres suggests that the peptides studied are involved in auditory, motor, gastric, feeding, vigilance, stress, respiratory and cardiovascular mechanisms, taste response, sleep-waking cycle and the control of pain transmission.

Idioma originalInglés
Páginas (desde-hasta)481-492
Número de páginas12
PublicaciónJournal of Veterinary Medicine Series C: Anatomia Histologia Embryologia
Volumen47
N.º5
DOI
EstadoPublicada - 1 oct 2018

Huella dactilar

New World Camelids
endorphins
beta-Endorphin
alpacas
corticotropin
brain stem
Adrenocorticotropic Hormone
Brain Stem
hormones
Hormones
peptides
pro-opiomelanocortin
Pro-Opiomelanocortin
Peptides
sleep
pain
Stomach
Sleep
stomach
alpha-neoendorphin

Citar esto

@article{31bcd9f4bd69454597c0bc6ac3f1a99d,
title = "Distribution of alpha-neoendorphin, ACTH (18–39) and beta-endorphin (1–27) in the alpaca brainstem",
abstract = "Using an immunocytochemical technique, we have studied in the alpaca brainstem the distribution of immunoreactive structures containing prodynorphin (alpha-neoendorphin)- and pro-opiomelanocortin (adrenocorticotrophin hormone (18–39) (ACTH), beta-endorphin (1–27))-derived peptides. No peptidergic-immunoreactive cell body was observed. Immunoreactive fibres were widely distributed, although in most of the brainstem nuclei the density of the peptidergic fibres was low or very low. In general, the distribution of the immunoreactive fibres containing the peptides studied was very similar. A close anatomical relationship occurred among the fibres containing alpha-neoendorphin, ACTH or beta-endorphin (1–27), suggesting a functional interaction among the three peptides in many of the brainstem nuclei. The number of fibres belonging to the prodynorphin system was higher than that of the pro-opiomelanocortin system. A moderate/low density of immunoreactive fibres was observed in 65.11{\%} (for alpha-neoendorphin (1–27)), 18.18{\%} (for ACTH) and 13.95{\%} (for beta-endorphin) of the brainstem nuclei/tracts. In the alpaca brainstem, a high density of immunoreactive fibres was not observed. The neuroanatomical distribution of the immunoreactive fibres suggests that the peptides studied are involved in auditory, motor, gastric, feeding, vigilance, stress, respiratory and cardiovascular mechanisms, taste response, sleep-waking cycle and the control of pain transmission.",
keywords = "Camelid, Lama pacos, mapping, pro-opiomelanocortin, prodynorphin",
author = "S{\'a}nchez, {Manuel L.} and {de Souza}, Eliana and Aguilar, {Luis A.} and Rafael Cove{\~n}as",
year = "2018",
month = "10",
day = "1",
doi = "10.1111/ahe.12387",
language = "Ingl{\'e}s",
volume = "47",
pages = "481--492",
journal = "Journal of Veterinary Medicine Series C: Anatomia Histologia Embryologia",
issn = "0340-2096",
publisher = "Wiley",
number = "5",

}

Distribution of alpha-neoendorphin, ACTH (18–39) and beta-endorphin (1–27) in the alpaca brainstem. / Sánchez, Manuel L.; de Souza, Eliana; Aguilar, Luis A.; Coveñas, Rafael.

En: Journal of Veterinary Medicine Series C: Anatomia Histologia Embryologia, Vol. 47, N.º 5, 01.10.2018, p. 481-492.

Resultado de la investigación: Contribución a una revistaArtículoInvestigaciónrevisión exhaustiva

TY - JOUR

T1 - Distribution of alpha-neoendorphin, ACTH (18–39) and beta-endorphin (1–27) in the alpaca brainstem

AU - Sánchez, Manuel L.

AU - de Souza, Eliana

AU - Aguilar, Luis A.

AU - Coveñas, Rafael

PY - 2018/10/1

Y1 - 2018/10/1

N2 - Using an immunocytochemical technique, we have studied in the alpaca brainstem the distribution of immunoreactive structures containing prodynorphin (alpha-neoendorphin)- and pro-opiomelanocortin (adrenocorticotrophin hormone (18–39) (ACTH), beta-endorphin (1–27))-derived peptides. No peptidergic-immunoreactive cell body was observed. Immunoreactive fibres were widely distributed, although in most of the brainstem nuclei the density of the peptidergic fibres was low or very low. In general, the distribution of the immunoreactive fibres containing the peptides studied was very similar. A close anatomical relationship occurred among the fibres containing alpha-neoendorphin, ACTH or beta-endorphin (1–27), suggesting a functional interaction among the three peptides in many of the brainstem nuclei. The number of fibres belonging to the prodynorphin system was higher than that of the pro-opiomelanocortin system. A moderate/low density of immunoreactive fibres was observed in 65.11% (for alpha-neoendorphin (1–27)), 18.18% (for ACTH) and 13.95% (for beta-endorphin) of the brainstem nuclei/tracts. In the alpaca brainstem, a high density of immunoreactive fibres was not observed. The neuroanatomical distribution of the immunoreactive fibres suggests that the peptides studied are involved in auditory, motor, gastric, feeding, vigilance, stress, respiratory and cardiovascular mechanisms, taste response, sleep-waking cycle and the control of pain transmission.

AB - Using an immunocytochemical technique, we have studied in the alpaca brainstem the distribution of immunoreactive structures containing prodynorphin (alpha-neoendorphin)- and pro-opiomelanocortin (adrenocorticotrophin hormone (18–39) (ACTH), beta-endorphin (1–27))-derived peptides. No peptidergic-immunoreactive cell body was observed. Immunoreactive fibres were widely distributed, although in most of the brainstem nuclei the density of the peptidergic fibres was low or very low. In general, the distribution of the immunoreactive fibres containing the peptides studied was very similar. A close anatomical relationship occurred among the fibres containing alpha-neoendorphin, ACTH or beta-endorphin (1–27), suggesting a functional interaction among the three peptides in many of the brainstem nuclei. The number of fibres belonging to the prodynorphin system was higher than that of the pro-opiomelanocortin system. A moderate/low density of immunoreactive fibres was observed in 65.11% (for alpha-neoendorphin (1–27)), 18.18% (for ACTH) and 13.95% (for beta-endorphin) of the brainstem nuclei/tracts. In the alpaca brainstem, a high density of immunoreactive fibres was not observed. The neuroanatomical distribution of the immunoreactive fibres suggests that the peptides studied are involved in auditory, motor, gastric, feeding, vigilance, stress, respiratory and cardiovascular mechanisms, taste response, sleep-waking cycle and the control of pain transmission.

KW - Camelid

KW - Lama pacos

KW - mapping

KW - pro-opiomelanocortin

KW - prodynorphin

UR - http://www.scopus.com/inward/record.url?scp=85050861412&partnerID=8YFLogxK

U2 - 10.1111/ahe.12387

DO - 10.1111/ahe.12387

M3 - Artículo

VL - 47

SP - 481

EP - 492

JO - Journal of Veterinary Medicine Series C: Anatomia Histologia Embryologia

JF - Journal of Veterinary Medicine Series C: Anatomia Histologia Embryologia

SN - 0340-2096

IS - 5

ER -