Confirmed Severe Acute Respiratory Syndrome Coronavirus 2 Reinfections After a Second Wave With Predominance of Lambda in Lima and Callao, Peru

Luis Pampa-Espinoza, Carlos Padilla-Rojas, Javier Silva-Valencia, Victor Jimenez-Vasquez, Iris Silva, Orson Mestanza, Priscila Lope Pari, Omar Cáceres, Henry Bailón-Calderón, Luis Bárcena-Flores, Marco Galarza, María García Mendoza, Ronnie Gavilán, Nancy Rojas Serrano, Miryam Palomino Rodriguez, Maribel Huaringa, Pamela Rios Monteza, Luis Ordoñez, Manuel Fernandez-Navarro, Natalia Vargas-HerreraLely Solari

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

Resumen

Background. Coronavirus disease 2019 (COVID-19) infection is a major public health problem in the world and reinfections are becoming more frequent. Our main objective was to describe the epidemiological, clinical, and genomic characteristics of the confirmed cases of reinfection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the capital of Lima and Callao, Peru. Methods. We searched in the Peruvian laboratory information system from April 2020 up to May 2021, looking for cases having 2 positive molecular tests for SARS-CoV-2 with more than 90 days between them. We performed genomic sequencing to the available pairs of samples and described the clinical characteristics, epidemiological impact, and genomic analysis of the confirmed reinfections. Results. There were 1 694 164 people with a positive diagnostic test for SARS-CoV-2 in Lima/Callao during the study period. Of these, 1695 had 2 positive molecular tests with more than 90 days between them. Two hundred eleven had both samples available for genomic analysis according to our selection criteria, and these were retrieved and submitted to sequencing. Thirty cases were confirmed to be SARS-CoV-2 reinfections with 2 different lineages in the 2 episodes. The variant Lambda (C.37) was the most common during the second infection and accounted for 19 (63.3%) of the 30 cases. Conclusions. We report 30 cases of confirmed SARS-CoV-2 reinfections. The Lambda variant was the most common cause of the second infections, in concordance with its predominant circulation during Peru's second wave. This report describes the largest series of confirmed reinfections by SARS-CoV-2 in Latin America.

Idioma originalInglés
Número de artículoofac134
PublicaciónOpen Forum Infectious Diseases
Volumen9
N.º6
DOI
EstadoPublicada - 1 jun. 2022
Publicado de forma externa

Huella

Profundice en los temas de investigación de 'Confirmed Severe Acute Respiratory Syndrome Coronavirus 2 Reinfections After a Second Wave With Predominance of Lambda in Lima and Callao, Peru'. En conjunto forman una huella única.

Citar esto