Association between waist circumference and waist-to-height ratio with insulin resistance biomarkers in normal-weight adults working in a private educational institution

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Resumen

Aim: To assess the association between elevated waist circumference (WC)and high waist-to-height ratio (WHtR)with insulin resistance biomarkers. Methods: We conducted an analytical cross-sectional study in normal-weight adults. Participants were divided in two groups according to WC or WHtR levels. We considered values of WC ≥ 90 in male participants and WC ≥ 80 in adult women as elevated, and values of WHtR≥0.50 as high, for both genders. Our outcomes were high triglycerides to HDL-cholesterol (TG/HDL-C)ratio and elevated triglycerides and glucose index (TGI). We considered values of TG/HDL-C ratio ≥ 3 as high and TGI values ≥ 8.37 as elevated. We elaborated crude and adjusted Poisson generalized linear models to evaluate the proposed associations and explored the gender interaction using stratified models. We reported the prevalence ratio (PR)with their respective 95% confidence intervals (95%CI). Results: We analyzed 355 participants. The prevalence of elevated WC and high WHtR was 17.2% (n = 61)and 33.2% (n = 118), respectively, while the prevalence of high TG/HDL-C ratio and elevated TGI was 24.8% (n = 88)and 12.7% (n = 45), respectively. In the adjusted regression model, elevated WC was associated with high TG/HDL-C ratio only in female participants (aPR = 3.61; 95%CI: 1.59–8.20). Similarly, high WHtR was associated with high TG/HDL-C ratio in women (aPR = 2.54; 95%CI:1.08–5.97). We found an association with statistically marginal significance between elevated WC and elevated TGI in women (aPR = 1.54; 95%CI: 0.95–2.50); as well as for the association between high WHtR and elevated TGI in male participants (aPR = 1.87; 95%CI: 1.00–3.50). Conclusion: Elevated WC and high WHtR were associated with a high TG/HDL-C ratio in women. It is necessary to perform prospective follow-up studies in the Peruvian population in order to corroborate our results.

Idioma originalInglés estadounidense
Páginas (desde-hasta)2041-2047
Número de páginas7
PublicaciónDiabetes and Metabolic Syndrome: Clinical Research and Reviews
Volumen13
N.º3
DOI
EstadoPublicada - 1 may 2019

Huella dactilar

Waist Circumference
Insulin Resistance
Triglycerides
Biomarkers
Weights and Measures
HDL Cholesterol
Confidence Intervals
Glucose
Waist-Height Ratio
Linear Models
Cross-Sectional Studies

Citar esto

@article{63a2ef6ef512447697240a03a060543f,
title = "Association between waist circumference and waist-to-height ratio with insulin resistance biomarkers in normal-weight adults working in a private educational institution",
abstract = "Aim: To assess the association between elevated waist circumference (WC)and high waist-to-height ratio (WHtR)with insulin resistance biomarkers. Methods: We conducted an analytical cross-sectional study in normal-weight adults. Participants were divided in two groups according to WC or WHtR levels. We considered values of WC ≥ 90 in male participants and WC ≥ 80 in adult women as elevated, and values of WHtR≥0.50 as high, for both genders. Our outcomes were high triglycerides to HDL-cholesterol (TG/HDL-C)ratio and elevated triglycerides and glucose index (TGI). We considered values of TG/HDL-C ratio ≥ 3 as high and TGI values ≥ 8.37 as elevated. We elaborated crude and adjusted Poisson generalized linear models to evaluate the proposed associations and explored the gender interaction using stratified models. We reported the prevalence ratio (PR)with their respective 95{\%} confidence intervals (95{\%}CI). Results: We analyzed 355 participants. The prevalence of elevated WC and high WHtR was 17.2{\%} (n = 61)and 33.2{\%} (n = 118), respectively, while the prevalence of high TG/HDL-C ratio and elevated TGI was 24.8{\%} (n = 88)and 12.7{\%} (n = 45), respectively. In the adjusted regression model, elevated WC was associated with high TG/HDL-C ratio only in female participants (aPR = 3.61; 95{\%}CI: 1.59–8.20). Similarly, high WHtR was associated with high TG/HDL-C ratio in women (aPR = 2.54; 95{\%}CI:1.08–5.97). We found an association with statistically marginal significance between elevated WC and elevated TGI in women (aPR = 1.54; 95{\%}CI: 0.95–2.50); as well as for the association between high WHtR and elevated TGI in male participants (aPR = 1.87; 95{\%}CI: 1.00–3.50). Conclusion: Elevated WC and high WHtR were associated with a high TG/HDL-C ratio in women. It is necessary to perform prospective follow-up studies in the Peruvian population in order to corroborate our results.",
keywords = "Cholesterol, HDL, Insulin resistance, Triglycerides, Waist circumference, Waist-height ratio",
author = "Diego Urrunaga-Pastor and {De La Fuente-Carmelino}, Luciana and Toro-Huamanchumo, {Carlos J.} and Miriam P{\'e}rez-Zavala and Benites-Zapata, {Vicente A.}",
year = "2019",
month = "5",
day = "1",
doi = "10.1016/j.dsx.2019.04.039",
language = "American English",
volume = "13",
pages = "2041--2047",
journal = "Diabetes and Metabolic Syndrome: Clinical Research and Reviews",
issn = "1871-4021",
publisher = "Elsevier",
number = "3",

}

TY - JOUR

T1 - Association between waist circumference and waist-to-height ratio with insulin resistance biomarkers in normal-weight adults working in a private educational institution

AU - Urrunaga-Pastor, Diego

AU - De La Fuente-Carmelino, Luciana

AU - Toro-Huamanchumo, Carlos J.

AU - Pérez-Zavala, Miriam

AU - Benites-Zapata, Vicente A.

PY - 2019/5/1

Y1 - 2019/5/1

N2 - Aim: To assess the association between elevated waist circumference (WC)and high waist-to-height ratio (WHtR)with insulin resistance biomarkers. Methods: We conducted an analytical cross-sectional study in normal-weight adults. Participants were divided in two groups according to WC or WHtR levels. We considered values of WC ≥ 90 in male participants and WC ≥ 80 in adult women as elevated, and values of WHtR≥0.50 as high, for both genders. Our outcomes were high triglycerides to HDL-cholesterol (TG/HDL-C)ratio and elevated triglycerides and glucose index (TGI). We considered values of TG/HDL-C ratio ≥ 3 as high and TGI values ≥ 8.37 as elevated. We elaborated crude and adjusted Poisson generalized linear models to evaluate the proposed associations and explored the gender interaction using stratified models. We reported the prevalence ratio (PR)with their respective 95% confidence intervals (95%CI). Results: We analyzed 355 participants. The prevalence of elevated WC and high WHtR was 17.2% (n = 61)and 33.2% (n = 118), respectively, while the prevalence of high TG/HDL-C ratio and elevated TGI was 24.8% (n = 88)and 12.7% (n = 45), respectively. In the adjusted regression model, elevated WC was associated with high TG/HDL-C ratio only in female participants (aPR = 3.61; 95%CI: 1.59–8.20). Similarly, high WHtR was associated with high TG/HDL-C ratio in women (aPR = 2.54; 95%CI:1.08–5.97). We found an association with statistically marginal significance between elevated WC and elevated TGI in women (aPR = 1.54; 95%CI: 0.95–2.50); as well as for the association between high WHtR and elevated TGI in male participants (aPR = 1.87; 95%CI: 1.00–3.50). Conclusion: Elevated WC and high WHtR were associated with a high TG/HDL-C ratio in women. It is necessary to perform prospective follow-up studies in the Peruvian population in order to corroborate our results.

AB - Aim: To assess the association between elevated waist circumference (WC)and high waist-to-height ratio (WHtR)with insulin resistance biomarkers. Methods: We conducted an analytical cross-sectional study in normal-weight adults. Participants were divided in two groups according to WC or WHtR levels. We considered values of WC ≥ 90 in male participants and WC ≥ 80 in adult women as elevated, and values of WHtR≥0.50 as high, for both genders. Our outcomes were high triglycerides to HDL-cholesterol (TG/HDL-C)ratio and elevated triglycerides and glucose index (TGI). We considered values of TG/HDL-C ratio ≥ 3 as high and TGI values ≥ 8.37 as elevated. We elaborated crude and adjusted Poisson generalized linear models to evaluate the proposed associations and explored the gender interaction using stratified models. We reported the prevalence ratio (PR)with their respective 95% confidence intervals (95%CI). Results: We analyzed 355 participants. The prevalence of elevated WC and high WHtR was 17.2% (n = 61)and 33.2% (n = 118), respectively, while the prevalence of high TG/HDL-C ratio and elevated TGI was 24.8% (n = 88)and 12.7% (n = 45), respectively. In the adjusted regression model, elevated WC was associated with high TG/HDL-C ratio only in female participants (aPR = 3.61; 95%CI: 1.59–8.20). Similarly, high WHtR was associated with high TG/HDL-C ratio in women (aPR = 2.54; 95%CI:1.08–5.97). We found an association with statistically marginal significance between elevated WC and elevated TGI in women (aPR = 1.54; 95%CI: 0.95–2.50); as well as for the association between high WHtR and elevated TGI in male participants (aPR = 1.87; 95%CI: 1.00–3.50). Conclusion: Elevated WC and high WHtR were associated with a high TG/HDL-C ratio in women. It is necessary to perform prospective follow-up studies in the Peruvian population in order to corroborate our results.

KW - Cholesterol

KW - HDL

KW - Insulin resistance

KW - Triglycerides

KW - Waist circumference

KW - Waist-height ratio

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U2 - 10.1016/j.dsx.2019.04.039

DO - 10.1016/j.dsx.2019.04.039

M3 - Article

VL - 13

SP - 2041

EP - 2047

JO - Diabetes and Metabolic Syndrome: Clinical Research and Reviews

JF - Diabetes and Metabolic Syndrome: Clinical Research and Reviews

SN - 1871-4021

IS - 3

ER -