Association between serum vitamin B12 levels and metabolic syndrome in a euthyroid population

Mirella Guarnizo-Poma, Diego Urrunaga-Pastor, Cory Montero-Suyo, Herbert Lazaro-Alcantara, Socorro Paico-Palacios, Betzi Pantoja-Torres, Vicente A. Benites-Zapata

Resultado de la investigación: Contribución a una revistaArtículoInvestigaciónrevisión exhaustiva

1 Cita (Scopus)

Resumen

© 2018 Diabetes India Aims: To determine the association between serum levels of vitamin B12 and metabolic syndrome (MetS) in a population of euthyroid adults. Materials and methods: We carried out an analytical cross-sectional study in euthyroid adults of both sexes, who attended the outpatient service of a private clinic in Lima-Peru during the 2012–2016 period. Participants were divided into tertiles (low, intermediate and high) according to their serum vitamin B12 values. MetS was defined when three or more metabolic criteria were met by the participants. We elaborated crude and adjusted Poisson regression models to evaluate the association between the serum vitamin B12 tertiles and the presence of MetS. The reported association measure was the prevalence ratio (PR) with their respective 95% confidence intervals (95%CI). Results: We analyzed 346 participants, the average age was 38.3 ± 10.8 (SD) years, 117 (33.8%) were males, the serum vitamin B12 median was 364.1 (IQR: 274.2–473.4) pmol/L and the prevalence of MetS was 30.1% (n = 104). In the crude Poisson regression model, we found an association between the serum vitamin B12 tertiles and the presence of MetS, with marginal significance. The association gained statistical significance in the adjusted model by potential confounders; and compared with the low serum vitamin B12 tertile, the prevalence of MetS was 36% lower (aPR = 0.64; 95%CI: 0.43–0.96) among the high tertile group. Conclusion: Euthyroid participants with elevated levels of serum vitamin B12 showed a lower prevalence of MetS compared to those who had low levels of this marker.
Idioma originalInglés estadounidense
Páginas (desde-hasta)943-948
Número de páginas6
PublicaciónDiabetes and Metabolic Syndrome: Clinical Research and Reviews
DOI
EstadoPublicada - 1 nov 2018

Huella dactilar

Vitamin B 12
Serum
Population
Confidence Intervals
Peru
Ambulatory Care
India
Cross-Sectional Studies

Citar esto

Guarnizo-Poma, Mirella ; Urrunaga-Pastor, Diego ; Montero-Suyo, Cory ; Lazaro-Alcantara, Herbert ; Paico-Palacios, Socorro ; Pantoja-Torres, Betzi ; Benites-Zapata, Vicente A. / Association between serum vitamin B12 levels and metabolic syndrome in a euthyroid population. En: Diabetes and Metabolic Syndrome: Clinical Research and Reviews. 2018 ; pp. 943-948.
@article{cc4f94fca39e4c52905a9c0793b5a57c,
title = "Association between serum vitamin B12 levels and metabolic syndrome in a euthyroid population",
abstract = "{\circledC} 2018 Diabetes India Aims: To determine the association between serum levels of vitamin B12 and metabolic syndrome (MetS) in a population of euthyroid adults. Materials and methods: We carried out an analytical cross-sectional study in euthyroid adults of both sexes, who attended the outpatient service of a private clinic in Lima-Peru during the 2012–2016 period. Participants were divided into tertiles (low, intermediate and high) according to their serum vitamin B12 values. MetS was defined when three or more metabolic criteria were met by the participants. We elaborated crude and adjusted Poisson regression models to evaluate the association between the serum vitamin B12 tertiles and the presence of MetS. The reported association measure was the prevalence ratio (PR) with their respective 95{\%} confidence intervals (95{\%}CI). Results: We analyzed 346 participants, the average age was 38.3 ± 10.8 (SD) years, 117 (33.8{\%}) were males, the serum vitamin B12 median was 364.1 (IQR: 274.2–473.4) pmol/L and the prevalence of MetS was 30.1{\%} (n = 104). In the crude Poisson regression model, we found an association between the serum vitamin B12 tertiles and the presence of MetS, with marginal significance. The association gained statistical significance in the adjusted model by potential confounders; and compared with the low serum vitamin B12 tertile, the prevalence of MetS was 36{\%} lower (aPR = 0.64; 95{\%}CI: 0.43–0.96) among the high tertile group. Conclusion: Euthyroid participants with elevated levels of serum vitamin B12 showed a lower prevalence of MetS compared to those who had low levels of this marker.",
author = "Mirella Guarnizo-Poma and Diego Urrunaga-Pastor and Cory Montero-Suyo and Herbert Lazaro-Alcantara and Socorro Paico-Palacios and Betzi Pantoja-Torres and Benites-Zapata, {Vicente A.}",
year = "2018",
month = "11",
day = "1",
doi = "10.1016/j.dsx.2018.05.022",
language = "American English",
pages = "943--948",
journal = "Diabetes and Metabolic Syndrome: Clinical Research and Reviews",
issn = "1871-4021",
publisher = "Elsevier",

}

Association between serum vitamin B12 levels and metabolic syndrome in a euthyroid population. / Guarnizo-Poma, Mirella; Urrunaga-Pastor, Diego; Montero-Suyo, Cory; Lazaro-Alcantara, Herbert; Paico-Palacios, Socorro; Pantoja-Torres, Betzi; Benites-Zapata, Vicente A.

En: Diabetes and Metabolic Syndrome: Clinical Research and Reviews, 01.11.2018, p. 943-948.

Resultado de la investigación: Contribución a una revistaArtículoInvestigaciónrevisión exhaustiva

TY - JOUR

T1 - Association between serum vitamin B12 levels and metabolic syndrome in a euthyroid population

AU - Guarnizo-Poma, Mirella

AU - Urrunaga-Pastor, Diego

AU - Montero-Suyo, Cory

AU - Lazaro-Alcantara, Herbert

AU - Paico-Palacios, Socorro

AU - Pantoja-Torres, Betzi

AU - Benites-Zapata, Vicente A.

PY - 2018/11/1

Y1 - 2018/11/1

N2 - © 2018 Diabetes India Aims: To determine the association between serum levels of vitamin B12 and metabolic syndrome (MetS) in a population of euthyroid adults. Materials and methods: We carried out an analytical cross-sectional study in euthyroid adults of both sexes, who attended the outpatient service of a private clinic in Lima-Peru during the 2012–2016 period. Participants were divided into tertiles (low, intermediate and high) according to their serum vitamin B12 values. MetS was defined when three or more metabolic criteria were met by the participants. We elaborated crude and adjusted Poisson regression models to evaluate the association between the serum vitamin B12 tertiles and the presence of MetS. The reported association measure was the prevalence ratio (PR) with their respective 95% confidence intervals (95%CI). Results: We analyzed 346 participants, the average age was 38.3 ± 10.8 (SD) years, 117 (33.8%) were males, the serum vitamin B12 median was 364.1 (IQR: 274.2–473.4) pmol/L and the prevalence of MetS was 30.1% (n = 104). In the crude Poisson regression model, we found an association between the serum vitamin B12 tertiles and the presence of MetS, with marginal significance. The association gained statistical significance in the adjusted model by potential confounders; and compared with the low serum vitamin B12 tertile, the prevalence of MetS was 36% lower (aPR = 0.64; 95%CI: 0.43–0.96) among the high tertile group. Conclusion: Euthyroid participants with elevated levels of serum vitamin B12 showed a lower prevalence of MetS compared to those who had low levels of this marker.

AB - © 2018 Diabetes India Aims: To determine the association between serum levels of vitamin B12 and metabolic syndrome (MetS) in a population of euthyroid adults. Materials and methods: We carried out an analytical cross-sectional study in euthyroid adults of both sexes, who attended the outpatient service of a private clinic in Lima-Peru during the 2012–2016 period. Participants were divided into tertiles (low, intermediate and high) according to their serum vitamin B12 values. MetS was defined when three or more metabolic criteria were met by the participants. We elaborated crude and adjusted Poisson regression models to evaluate the association between the serum vitamin B12 tertiles and the presence of MetS. The reported association measure was the prevalence ratio (PR) with their respective 95% confidence intervals (95%CI). Results: We analyzed 346 participants, the average age was 38.3 ± 10.8 (SD) years, 117 (33.8%) were males, the serum vitamin B12 median was 364.1 (IQR: 274.2–473.4) pmol/L and the prevalence of MetS was 30.1% (n = 104). In the crude Poisson regression model, we found an association between the serum vitamin B12 tertiles and the presence of MetS, with marginal significance. The association gained statistical significance in the adjusted model by potential confounders; and compared with the low serum vitamin B12 tertile, the prevalence of MetS was 36% lower (aPR = 0.64; 95%CI: 0.43–0.96) among the high tertile group. Conclusion: Euthyroid participants with elevated levels of serum vitamin B12 showed a lower prevalence of MetS compared to those who had low levels of this marker.

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85047498892&origin=inward

UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85047498892&origin=inward

U2 - 10.1016/j.dsx.2018.05.022

DO - 10.1016/j.dsx.2018.05.022

M3 - Article

SP - 943

EP - 948

JO - Diabetes and Metabolic Syndrome: Clinical Research and Reviews

JF - Diabetes and Metabolic Syndrome: Clinical Research and Reviews

SN - 1871-4021

ER -