TY - JOUR
T1 - Association between Lipid Profile and Apolipoproteins with Risk of Diabetic Foot Ulcer
T2 - A Systematic Review and Meta-Analysis
AU - Ulloque-Badaracco, Juan R.
AU - Mosquera-Rojas, Melany D.
AU - Hernandez-Bustamante, Enrique A.
AU - Alarcón-Braga, Esteban A.
AU - Ulloque-Badaracco, Ricardo R.
AU - Al-Kassab-Córdova, Ali
AU - Herrera-Añazco, Percy
AU - Benites-Zapata, Vicente A.
AU - Hernandez, Adrian V.
N1 - Publisher Copyright:
© 2022 Juan R. Ulloque-Badaracco et al.
PY - 2022
Y1 - 2022
N2 - Background and Aims. Biomarkers are necessary to stratify the risk of diabetic foot ulcers (DFUs). This systematic review and meta-analysis aimed to evaluate the association between the lipid profile and apolipoproteins with the risk of DFU. Methods. A systematic search was conducted in PubMed, Scopus, Cochrane Library, and Web of Science among adult patients. Cohort and case-control studies were included. Random-effects models were used for meta-analyses, and the effects were expressed as odds ratio (OR) and their 95% confidence intervals (CIs). We evaluated publication bias through Egger's test and funnel plot. Results. A total of 12 cohort studies and 26 case-control studies were included, with 17076 patients. We found that the higher values of total cholesterol (TC), low-density lipoprotein (LDL), triglycerides, and lipoprotein(a) (Lp(a)) were associated with a higher risk of developing DFU (OR: 1.47, OR: 1.47, OR: 1.5, OR: 1.85, respectively). Otherwise, the lower values of HDL were associated with a higher risk of developing DFU (OR: 0.49). Publication bias was not found for associations between TC, HDL, LDL, or TG and the risk of DFU. Conclusions. The high values of LDL, TC, TG, and Lp(a) and low values of HDL are associated with a higher risk of developing DFU. Furthermore, we did not find a significant association for VLDL, ApoA1, ApoB, and ApoB/ApoA1 ratio.
AB - Background and Aims. Biomarkers are necessary to stratify the risk of diabetic foot ulcers (DFUs). This systematic review and meta-analysis aimed to evaluate the association between the lipid profile and apolipoproteins with the risk of DFU. Methods. A systematic search was conducted in PubMed, Scopus, Cochrane Library, and Web of Science among adult patients. Cohort and case-control studies were included. Random-effects models were used for meta-analyses, and the effects were expressed as odds ratio (OR) and their 95% confidence intervals (CIs). We evaluated publication bias through Egger's test and funnel plot. Results. A total of 12 cohort studies and 26 case-control studies were included, with 17076 patients. We found that the higher values of total cholesterol (TC), low-density lipoprotein (LDL), triglycerides, and lipoprotein(a) (Lp(a)) were associated with a higher risk of developing DFU (OR: 1.47, OR: 1.47, OR: 1.5, OR: 1.85, respectively). Otherwise, the lower values of HDL were associated with a higher risk of developing DFU (OR: 0.49). Publication bias was not found for associations between TC, HDL, LDL, or TG and the risk of DFU. Conclusions. The high values of LDL, TC, TG, and Lp(a) and low values of HDL are associated with a higher risk of developing DFU. Furthermore, we did not find a significant association for VLDL, ApoA1, ApoB, and ApoB/ApoA1 ratio.
KW - Adult
KW - Apolipoproteins
KW - Apolipoproteins B
KW - Case-Control Studies
KW - Cholesterol, HDL
KW - Diabetes Mellitus
KW - Diabetic Foot
KW - Humans
KW - Triglycerides
UR - http://www.scopus.com/inward/record.url?scp=85136540052&partnerID=8YFLogxK
U2 - 10.1155/2022/5450173
DO - 10.1155/2022/5450173
M3 - Artículo de revisión
C2 - 36016824
AN - SCOPUS:85136540052
SN - 1368-5031
VL - 2022
JO - International Journal of Clinical Practice
JF - International Journal of Clinical Practice
M1 - 5450173
ER -
