TY - JOUR
T1 - Acute disseminated encephalomyelitis and COVID-19
T2 - A systematic synthesis of worldwide cases
AU - Zelada-Ríos, Laura
AU - Pacheco-Barrios, Kevin
AU - Galecio-Castillo, Milagros
AU - Yamunaqué-Chunga, Cesar
AU - Álvarez-Toledo, Kelvin
AU - Otiniano-Sifuentes, Ricardo
N1 - Copyright © 2021 Elsevier B.V. All rights reserved.
PY - 2021/10/15
Y1 - 2021/10/15
N2 - Acute disseminated encephalomyelitis (ADEM) has been reported after coronavirus disease 2019 (COVID-19). In this review, we systematically included worldwide reported cases on this association. We included 30 case reports (pediatric and adults) and explored epidemiological and clinical evidence. We described time to diagnosis, clinical, imaging, and laboratory features, response to treatment regimens, and differences regarding severity. Also, an original case report was presented. Neurologists must be alert to the occurrence of multifocal neurological symptoms with or without encephalopathy in patients recovered from COVID-19. Timely MRI studies should be performed to establish the diagnosis and to consider early corticosteroid-based treatment.
AB - Acute disseminated encephalomyelitis (ADEM) has been reported after coronavirus disease 2019 (COVID-19). In this review, we systematically included worldwide reported cases on this association. We included 30 case reports (pediatric and adults) and explored epidemiological and clinical evidence. We described time to diagnosis, clinical, imaging, and laboratory features, response to treatment regimens, and differences regarding severity. Also, an original case report was presented. Neurologists must be alert to the occurrence of multifocal neurological symptoms with or without encephalopathy in patients recovered from COVID-19. Timely MRI studies should be performed to establish the diagnosis and to consider early corticosteroid-based treatment.
KW - Acute disseminated encephalomyelitis (ADEM)
KW - Autoimmune disease
KW - Central nervous system (CNS)
KW - Coronavirus disease 2019 (COVID-19)
KW - Demyelinating disease
KW - SARS-Cov-2
KW - COVID-19/complications
KW - Global Health
KW - Humans
KW - Male
KW - Methylprednisolone/therapeutic use
KW - Observational Studies as Topic/methods
KW - Adult
KW - Encephalomyelitis, Acute Disseminated/diagnostic imaging
UR - http://www.scopus.com/inward/record.url?scp=85111977022&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/9918761c-1763-3c63-9fa2-b79c5ed2e536/
U2 - 10.1016/j.jneuroim.2021.577674
DO - 10.1016/j.jneuroim.2021.577674
M3 - Artículo de revisión
C2 - 34371208
AN - SCOPUS:85111977022
SN - 0165-5728
VL - 359
SP - 577674
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
M1 - 577674
ER -
