AB0505 Age at Diagnosis and Health-Related Quality of Life are Associated with Fatigue in Systemic Lupus Erythematosus Patients: Abstracts Accepted for Publication

Claudia Elera-Fitzcarrald, Cristina Reategui Sokolova, Rocío Violeta Gamboa Cárdenas, Mariela Medina, Francisco Zevallos Miranda, Victor Pimentel Quiroz, Paola Alejandra Zeña Huancas, Erika Noriega, Cesar Pastor Asurza, Risto Perich Campos, Zoila Rodriguez Bellido, Graciela S. Alarcon, Manuel F. Ugarte-Gil

Resultado de la investigación: Contribución a una revistaResumen de conferenciaInvestigaciónrevisión exhaustiva

Resumen

Background: Fatigue can be defined as feeling tired and exhausted and lacking energy (1). It is associated with a poor quality of life; 53 to 80% of SLE patients identify fatigue as their main symptom (2)

Objectives: To define factors associated with fatigue in Mestizo patients with Systemic Lupus Erythematosus (SLE).

Methods: This is a cross-sectional study of SLE patients from a single center cohort. Visits were performed every six months. For these analyses, the first visit between October 2017 and December 2018 was included. Demographic and clinical characteristics as well as treatment were recorded at every visit. Socioeconomic status (SES) was defined using the Graffar’s method (ref). Fatigue was ascertained with the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-FT), Health-Related Quality of Life (HRQoL) with the LupusQoL, disease activity with the Systemic Lupus Erythematosus Disease Activity Index –2K (SLEDAI-2K), and damage with the Systemic Lupus International Collaborating Clinics (SLICC)/American College of Rheumatology (ACR) damage index (SDI). Prednisone use was recorded as current daily dose. Immunosuppressive drugs and antimalarial use was recorded as current, past or never. Univariable and multivariable analyses were performed using linear regression models. For the multivariable analyses, model selection was based on backward elimination.

Results: Two hundred and twenty-six patients were evaluated. The mean (SD) age at diagnosis was 35.6 (13.1) years, 211 (93.4%) were female; and disease duration was 11.0 (7.3) years. The mean SLEDAI and SDI were 2.4 (3.5) and 1.3 (1.5), respectively. The mean FACIT-Fatigue was 33.1 (10.8). In the univariable analyses, FACIT-Fatigue correlated with age at diagnosis, SES, disease duration and all the HRQoL domains like physical health, pain, planning, intimate relationships, burden to others, emotional health, body image and fatigue. On the multivariable analysis, however, only age at diagnosis; and some domains of HRQoL (physical health, emotional health and fatigue) remained associated. Theses analyses are depicted in table 1.

Conclusion: Age at diagnosis is negatively associated with fatigue; HRQoL domains like physical health, emotional health and fatigue are positively associated with fatigue.
Idioma originalInglés
PublicaciónAnnals of the Rheumatic Diseases
DOI
EstadoPublicada - jun 2019

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Elera-Fitzcarrald, Claudia ; Sokolova, Cristina Reategui ; Gamboa Cárdenas, Rocío Violeta ; Medina, Mariela ; Miranda, Francisco Zevallos ; Quiroz, Victor Pimentel ; Zeña Huancas, Paola Alejandra ; Noriega, Erika ; Asurza, Cesar Pastor ; Campos, Risto Perich ; Bellido, Zoila Rodriguez ; Alarcon, Graciela S. ; Ugarte-Gil, Manuel F. / AB0505 Age at Diagnosis and Health-Related Quality of Life are Associated with Fatigue in Systemic Lupus Erythematosus Patients : Abstracts Accepted for Publication. En: Annals of the Rheumatic Diseases. 2019.
@article{63990040ca25458ab09057b213666d20,
title = "AB0505 Age at Diagnosis and Health-Related Quality of Life are Associated with Fatigue in Systemic Lupus Erythematosus Patients: Abstracts Accepted for Publication",
abstract = "Background: Fatigue can be defined as feeling tired and exhausted and lacking energy (1). It is associated with a poor quality of life; 53 to 80{\%} of SLE patients identify fatigue as their main symptom (2)Objectives: To define factors associated with fatigue in Mestizo patients with Systemic Lupus Erythematosus (SLE).Methods: This is a cross-sectional study of SLE patients from a single center cohort. Visits were performed every six months. For these analyses, the first visit between October 2017 and December 2018 was included. Demographic and clinical characteristics as well as treatment were recorded at every visit. Socioeconomic status (SES) was defined using the Graffar’s method (ref). Fatigue was ascertained with the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-FT), Health-Related Quality of Life (HRQoL) with the LupusQoL, disease activity with the Systemic Lupus Erythematosus Disease Activity Index –2K (SLEDAI-2K), and damage with the Systemic Lupus International Collaborating Clinics (SLICC)/American College of Rheumatology (ACR) damage index (SDI). Prednisone use was recorded as current daily dose. Immunosuppressive drugs and antimalarial use was recorded as current, past or never. Univariable and multivariable analyses were performed using linear regression models. For the multivariable analyses, model selection was based on backward elimination.Results: Two hundred and twenty-six patients were evaluated. The mean (SD) age at diagnosis was 35.6 (13.1) years, 211 (93.4{\%}) were female; and disease duration was 11.0 (7.3) years. The mean SLEDAI and SDI were 2.4 (3.5) and 1.3 (1.5), respectively. The mean FACIT-Fatigue was 33.1 (10.8). In the univariable analyses, FACIT-Fatigue correlated with age at diagnosis, SES, disease duration and all the HRQoL domains like physical health, pain, planning, intimate relationships, burden to others, emotional health, body image and fatigue. On the multivariable analysis, however, only age at diagnosis; and some domains of HRQoL (physical health, emotional health and fatigue) remained associated. Theses analyses are depicted in table 1.Conclusion: Age at diagnosis is negatively associated with fatigue; HRQoL domains like physical health, emotional health and fatigue are positively associated with fatigue.",
author = "Claudia Elera-Fitzcarrald and Sokolova, {Cristina Reategui} and {Gamboa C{\'a}rdenas}, {Roc{\'i}o Violeta} and Mariela Medina and Miranda, {Francisco Zevallos} and Quiroz, {Victor Pimentel} and {Ze{\~n}a Huancas}, {Paola Alejandra} and Erika Noriega and Asurza, {Cesar Pastor} and Campos, {Risto Perich} and Bellido, {Zoila Rodriguez} and Alarcon, {Graciela S.} and Ugarte-Gil, {Manuel F.}",
year = "2019",
month = "6",
doi = "10.1136/annrheumdis-2019-eular.5088",
language = "Ingl{\'e}s",
journal = "Annals of the Rheumatic Diseases",

}

Elera-Fitzcarrald, C, Sokolova, CR, Gamboa Cárdenas, RV, Medina, M, Miranda, FZ, Quiroz, VP, Zeña Huancas, PA, Noriega, E, Asurza, CP, Campos, RP, Bellido, ZR, Alarcon, GS & Ugarte-Gil, MF 2019, 'AB0505 Age at Diagnosis and Health-Related Quality of Life are Associated with Fatigue in Systemic Lupus Erythematosus Patients: Abstracts Accepted for Publication', Annals of the Rheumatic Diseases. https://doi.org/10.1136/annrheumdis-2019-eular.5088

AB0505 Age at Diagnosis and Health-Related Quality of Life are Associated with Fatigue in Systemic Lupus Erythematosus Patients : Abstracts Accepted for Publication. / Elera-Fitzcarrald, Claudia; Sokolova, Cristina Reategui; Gamboa Cárdenas, Rocío Violeta; Medina, Mariela; Miranda, Francisco Zevallos; Quiroz, Victor Pimentel; Zeña Huancas, Paola Alejandra; Noriega, Erika; Asurza, Cesar Pastor; Campos, Risto Perich; Bellido, Zoila Rodriguez; Alarcon, Graciela S.; Ugarte-Gil, Manuel F.

En: Annals of the Rheumatic Diseases, 06.2019.

Resultado de la investigación: Contribución a una revistaResumen de conferenciaInvestigaciónrevisión exhaustiva

TY - JOUR

T1 - AB0505 Age at Diagnosis and Health-Related Quality of Life are Associated with Fatigue in Systemic Lupus Erythematosus Patients

T2 - Abstracts Accepted for Publication

AU - Elera-Fitzcarrald, Claudia

AU - Sokolova, Cristina Reategui

AU - Gamboa Cárdenas, Rocío Violeta

AU - Medina, Mariela

AU - Miranda, Francisco Zevallos

AU - Quiroz, Victor Pimentel

AU - Zeña Huancas, Paola Alejandra

AU - Noriega, Erika

AU - Asurza, Cesar Pastor

AU - Campos, Risto Perich

AU - Bellido, Zoila Rodriguez

AU - Alarcon, Graciela S.

AU - Ugarte-Gil, Manuel F.

PY - 2019/6

Y1 - 2019/6

N2 - Background: Fatigue can be defined as feeling tired and exhausted and lacking energy (1). It is associated with a poor quality of life; 53 to 80% of SLE patients identify fatigue as their main symptom (2)Objectives: To define factors associated with fatigue in Mestizo patients with Systemic Lupus Erythematosus (SLE).Methods: This is a cross-sectional study of SLE patients from a single center cohort. Visits were performed every six months. For these analyses, the first visit between October 2017 and December 2018 was included. Demographic and clinical characteristics as well as treatment were recorded at every visit. Socioeconomic status (SES) was defined using the Graffar’s method (ref). Fatigue was ascertained with the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-FT), Health-Related Quality of Life (HRQoL) with the LupusQoL, disease activity with the Systemic Lupus Erythematosus Disease Activity Index –2K (SLEDAI-2K), and damage with the Systemic Lupus International Collaborating Clinics (SLICC)/American College of Rheumatology (ACR) damage index (SDI). Prednisone use was recorded as current daily dose. Immunosuppressive drugs and antimalarial use was recorded as current, past or never. Univariable and multivariable analyses were performed using linear regression models. For the multivariable analyses, model selection was based on backward elimination.Results: Two hundred and twenty-six patients were evaluated. The mean (SD) age at diagnosis was 35.6 (13.1) years, 211 (93.4%) were female; and disease duration was 11.0 (7.3) years. The mean SLEDAI and SDI were 2.4 (3.5) and 1.3 (1.5), respectively. The mean FACIT-Fatigue was 33.1 (10.8). In the univariable analyses, FACIT-Fatigue correlated with age at diagnosis, SES, disease duration and all the HRQoL domains like physical health, pain, planning, intimate relationships, burden to others, emotional health, body image and fatigue. On the multivariable analysis, however, only age at diagnosis; and some domains of HRQoL (physical health, emotional health and fatigue) remained associated. Theses analyses are depicted in table 1.Conclusion: Age at diagnosis is negatively associated with fatigue; HRQoL domains like physical health, emotional health and fatigue are positively associated with fatigue.

AB - Background: Fatigue can be defined as feeling tired and exhausted and lacking energy (1). It is associated with a poor quality of life; 53 to 80% of SLE patients identify fatigue as their main symptom (2)Objectives: To define factors associated with fatigue in Mestizo patients with Systemic Lupus Erythematosus (SLE).Methods: This is a cross-sectional study of SLE patients from a single center cohort. Visits were performed every six months. For these analyses, the first visit between October 2017 and December 2018 was included. Demographic and clinical characteristics as well as treatment were recorded at every visit. Socioeconomic status (SES) was defined using the Graffar’s method (ref). Fatigue was ascertained with the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-FT), Health-Related Quality of Life (HRQoL) with the LupusQoL, disease activity with the Systemic Lupus Erythematosus Disease Activity Index –2K (SLEDAI-2K), and damage with the Systemic Lupus International Collaborating Clinics (SLICC)/American College of Rheumatology (ACR) damage index (SDI). Prednisone use was recorded as current daily dose. Immunosuppressive drugs and antimalarial use was recorded as current, past or never. Univariable and multivariable analyses were performed using linear regression models. For the multivariable analyses, model selection was based on backward elimination.Results: Two hundred and twenty-six patients were evaluated. The mean (SD) age at diagnosis was 35.6 (13.1) years, 211 (93.4%) were female; and disease duration was 11.0 (7.3) years. The mean SLEDAI and SDI were 2.4 (3.5) and 1.3 (1.5), respectively. The mean FACIT-Fatigue was 33.1 (10.8). In the univariable analyses, FACIT-Fatigue correlated with age at diagnosis, SES, disease duration and all the HRQoL domains like physical health, pain, planning, intimate relationships, burden to others, emotional health, body image and fatigue. On the multivariable analysis, however, only age at diagnosis; and some domains of HRQoL (physical health, emotional health and fatigue) remained associated. Theses analyses are depicted in table 1.Conclusion: Age at diagnosis is negatively associated with fatigue; HRQoL domains like physical health, emotional health and fatigue are positively associated with fatigue.

UR - http://www.mendeley.com/research/ab0505-age-diagnosis-healthrelated-quality-life-associated-fatigue-systemic-lupus-erythematosus-pati

U2 - 10.1136/annrheumdis-2019-eular.5088

DO - 10.1136/annrheumdis-2019-eular.5088

M3 - Resumen de conferencia

JO - Annals of the Rheumatic Diseases

JF - Annals of the Rheumatic Diseases

ER -