TY - JOUR
T1 - A Functional Assessment Tool to Distinguish Controls From Alzheimer’s Disease in Lima, Peru
AU - Custodio, Nilton
AU - Montesinos, Rosa
AU - Chambergo-Michilot, Diego
AU - Herrera-Perez, Eder
AU - Pintado-Caipa, Maritza
AU - Seminario G, Wendy
AU - Cuenca, José
AU - Mesía, Laura
AU - Failoc-Rojas, Virgilio E.
AU - Diaz, Monica M.
N1 - Publisher Copyright:
© The Author(s) 2022.
PY - 2022/5
Y1 - 2022/5
N2 - Background: The Alzheimer’s Disease Cooperative Study-Activities of Daily Living (ADCS-ADL) scale is a versatile functional assessment tool for patients with Alzheimer’s disease (ad). We evaluated its performance in controls, Peruvians with MCI or AD. Methods: A cross-sectional study of older adults attending a neurology institute in Lima (Peru) with mild cognitive impairment (MCI), ad or cognitively healthy. Test-retest reliability (intraclass correlation coefficient, ICC; internal consistency, Cronbach’s alpha) and validity were assessed. Results: We enrolled 276 individuals (ad: 113, MCI: 68, controls: 95) with no age, sex, educational level, and depressive symptom differences. Reliability was ideal (ICC:.996), and Cronbach’s alpha was adequate (.937). The ADCS-ADL could not differentiate MCI from controls but did differentiate ad severity. The ADCS-ADL correlated highly with nearly all tools. Conclusions: The ADCS-ADL scale is reliable in a population with ad in Lima, Peru. Future work may validate a tool for Peruvians with lower educational levels.
AB - Background: The Alzheimer’s Disease Cooperative Study-Activities of Daily Living (ADCS-ADL) scale is a versatile functional assessment tool for patients with Alzheimer’s disease (ad). We evaluated its performance in controls, Peruvians with MCI or AD. Methods: A cross-sectional study of older adults attending a neurology institute in Lima (Peru) with mild cognitive impairment (MCI), ad or cognitively healthy. Test-retest reliability (intraclass correlation coefficient, ICC; internal consistency, Cronbach’s alpha) and validity were assessed. Results: We enrolled 276 individuals (ad: 113, MCI: 68, controls: 95) with no age, sex, educational level, and depressive symptom differences. Reliability was ideal (ICC:.996), and Cronbach’s alpha was adequate (.937). The ADCS-ADL could not differentiate MCI from controls but did differentiate ad severity. The ADCS-ADL correlated highly with nearly all tools. Conclusions: The ADCS-ADL scale is reliable in a population with ad in Lima, Peru. Future work may validate a tool for Peruvians with lower educational levels.
KW - alzheimer disease
KW - dementia
KW - neurocognitive disorders
KW - peru
KW - validation study
UR - http://www.scopus.com/inward/record.url?scp=85131337544&partnerID=8YFLogxK
U2 - 10.1177/15333175221104354
DO - 10.1177/15333175221104354
M3 - Artículo
C2 - 35656899
AN - SCOPUS:85131337544
SN - 1533-3175
VL - 37
JO - American Journal of Alzheimer's Disease and other Dementias
JF - American Journal of Alzheimer's Disease and other Dementias
ER -
