TY - JOUR
T1 - 30-day Morbidity and Mortality after Cholecystectomy for Benign Gallbladder Disease (AMBROSE)
T2 - A Prospective, International Collaborative Cohort Study
AU - AMBROSE Collaborative
AU - Wong, Geoffrey Yuet Mun
AU - Wadhawan, Himanshu
AU - Roth Cardoso, Victor
AU - Bravo Merodio, Laura
AU - Rajeev, Yashasvi
AU - Maldonado, Ricardo David
AU - Martinino, Alessandro
AU - Balasubaramaniam, Vignesh
AU - Ashraf, Aabid
AU - Siddiqui, Adeela
AU - Al-Shkirat, Ahmad Ghassan
AU - Mohammed Abu-Elfatth, Ahmed
AU - Gupta, Ajay
AU - Alkaseek, Akram
AU - Ouyahia, Amel
AU - Said, Amira
AU - Pandey, Anshuman
AU - Kumar, Ashwani
AU - Maqbool, Baila
AU - Millán, Carlos Alberto
AU - Singh, Cheena
AU - Pantoja Pachajoa, Diana Alejandra
AU - Adamovich, Dmitry Mikhailovich
AU - Petracchi, Enrique
AU - Ashraf, Fariha
AU - Clementi, Marco
AU - Mulita, Francesk
AU - Marom, Gad Amram
AU - Abdulaal, Gamaleldeen
AU - Verras, Georgios Ioannis
AU - Calini, Giacomo
AU - Moretto, Gianluigi
AU - Elfeki, Hossam
AU - Liang, Hui
AU - Jalaawiy, Humam
AU - Elzayat, Ibrahim
AU - Das, Jayanta Kumar
AU - Aceves-Ayala, Jose Miguel
AU - Ahmed, Kazi T.
AU - Degrate, Luca
AU - Aggarwal, Manisha
AU - Omar, Mohammed Ahmed
AU - Rais, Mounira
AU - Elhadi, Muhammed
AU - Sakran, Nasser
AU - Bhojwani, Rajesh
AU - Agarwalla, Ramesh
AU - Kanaan, Samir
AU - Erdene, Sarnai
AU - Toro-Huamanchumo, Carlos J.
N1 - Publisher Copyright:
Copyright © 2024 The Author(s).
PY - 2025/2/1
Y1 - 2025/2/1
N2 - Objective: This study aimed to assess 30-day morbidity and mortality rates following cholecystectomy for benign gallbladder disease and identify the factors associated with complications. Background: Although cholecystectomy is common for benign gallbladder disease, there is a gap in the knowledge of the current practice and variations on a global level. Methods: A prospective, international, observational collaborative cohort study of consecutive patients undergoing cholecystectomy for benign gallbladder disease from participating hospitals in 57 countries between January 1 and June 30, 2022, was performed. Univariate and multivariate logistic regression models were used to identify preoperative and operative variables associated with 30-day postoperative outcomes. Results: Data of 21,706 surgical patients from 57 countries were included in the analysis. A total of 10,821 (49.9%), 4263 (19.7%), and 6622 (30.5%) cholecystectomies were performed in the elective, emergency, and delayed settings, respectively. Thirty-day postoperative complications were observed in 1738 patients (8.0%), including mortality in 83 patients (0.4%). Bile leaks (Strasberg grade A) were reported in 278 (1.3%) patients, and severe bile duct injuries (Strasberg grades B-E) were reported in 48 (0.2%) patients. Patient age, American Society of Anesthesiologists physical status class, surgical setting, operative approach, and Nassar operative difficulty grade were identified as the 5 predictors demonstrating the highest relative importance in predicting postoperative complications. Conclusions: This multinational observational collaborative cohort study presents a comprehensive report of the current practices and outcomes of cholecystectomy for benign gallbladder disease. Ongoing global collaborative evaluations and initiatives are needed to promote quality assurance and improvement in cholecystectomy.
AB - Objective: This study aimed to assess 30-day morbidity and mortality rates following cholecystectomy for benign gallbladder disease and identify the factors associated with complications. Background: Although cholecystectomy is common for benign gallbladder disease, there is a gap in the knowledge of the current practice and variations on a global level. Methods: A prospective, international, observational collaborative cohort study of consecutive patients undergoing cholecystectomy for benign gallbladder disease from participating hospitals in 57 countries between January 1 and June 30, 2022, was performed. Univariate and multivariate logistic regression models were used to identify preoperative and operative variables associated with 30-day postoperative outcomes. Results: Data of 21,706 surgical patients from 57 countries were included in the analysis. A total of 10,821 (49.9%), 4263 (19.7%), and 6622 (30.5%) cholecystectomies were performed in the elective, emergency, and delayed settings, respectively. Thirty-day postoperative complications were observed in 1738 patients (8.0%), including mortality in 83 patients (0.4%). Bile leaks (Strasberg grade A) were reported in 278 (1.3%) patients, and severe bile duct injuries (Strasberg grades B-E) were reported in 48 (0.2%) patients. Patient age, American Society of Anesthesiologists physical status class, surgical setting, operative approach, and Nassar operative difficulty grade were identified as the 5 predictors demonstrating the highest relative importance in predicting postoperative complications. Conclusions: This multinational observational collaborative cohort study presents a comprehensive report of the current practices and outcomes of cholecystectomy for benign gallbladder disease. Ongoing global collaborative evaluations and initiatives are needed to promote quality assurance and improvement in cholecystectomy.
KW - benign gallbladder disease
KW - bile duct injury
KW - cholecystectomy
KW - complications
KW - morbidity
KW - mortality
UR - http://www.scopus.com/inward/record.url?scp=85206663796&partnerID=8YFLogxK
U2 - 10.1097/SLA.0000000000006236
DO - 10.1097/SLA.0000000000006236
M3 - Artículo
C2 - 38348652
AN - SCOPUS:85206663796
SN - 0003-4932
VL - 281
SP - 312
EP - 321
JO - Annals of Surgery
JF - Annals of Surgery
IS - 2
ER -