Volumen plaquetario medio como predictor de la mortalidad en pacientes con sepsis: Revisión sistemática y metanálisis

Jorge Luis Vélez-Paez; Carlos Velarde-Montero; Estefanía Irigoyen-Mogro; Pablo Vélez-Páez; Paulina Cifuentes-López; Jorge W. Vélez; Leonardo Albitres-Flores; Joshuan J. Barboza

doi:10.22354/in.v24i3.861

Volumen plaquetario medio como predictor de la mortalidad en pacientes con sepsis: Revisión sistemática y metanálisis

Translated title of the contribution: Mean platelet volume as a predictor of mortality in patients with sepsis: Systematic review and meta-analysis

Jorge Luis Vélez-Paez, Carlos Velarde-Montero, Estefanía Irigoyen-Mogro, Pablo Vélez-Páez, Paulina Cifuentes-López, Jorge W. Vélez, Leonardo Albitres-Flores, Joshuan J. Barboza

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Introduction: Platelet mean volume (MVP) is a biomarker used in the integral approach to sepsis. Objective: To assess the association between MVP and mortality in patients with sepsis. Methods: A systematic review of observational studies in five databases was performed. Mortality associated with sepsis was analysed; interventions considered were MPV, APACHE and serum lactate. Results: Regarding mortality associated with sepsis, a significant value was found in the MVP at 72 hours (200 deceased versus 654 not deceased; MD 0.83 IC95% 0.53-1.13, p= <0.0001, I2=72.9%); as well as the value of APACHE II (220 dead versus 604 not deceased; MD 0.81 IC95% 0.62-1.0, p= <0.0001, I2=32%). No statistical significance was found for the other clinical variables. Conclusions: Increased MVP is associated with increased risk of mortality in patients with sepsis, especially after 72 hours of evolution of clinical features.

Translated title of the contribution	Mean platelet volume as a predictor of mortality in patients with sepsis: Systematic review and meta-analysis
Original language	Spanish
Pages (from-to)	162-168
Number of pages	7
Journal	Infectio
Volume	24
Issue number	3
DOIs	https://doi.org/10.22354/in.v24i3.861
State	Published - 2020

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@article{7c972ffdafe849989357015245e459f9,

title = "Volumen plaquetario medio como predictor de la mortalidad en pacientes con sepsis: Revisi{\'o}n sistem{\'a}tica y metan{\'a}lisis",

abstract = "Introduction: Platelet mean volume (MVP) is a biomarker used in the integral approach to sepsis. Objective: To assess the association between MVP and mortality in patients with sepsis. Methods: A systematic review of observational studies in five databases was performed. Mortality associated with sepsis was analysed; interventions considered were MPV, APACHE and serum lactate. Results: Regarding mortality associated with sepsis, a significant value was found in the MVP at 72 hours (200 deceased versus 654 not deceased; MD 0.83 IC95% 0.53-1.13, p= <0.0001, I2=72.9%); as well as the value of APACHE II (220 dead versus 604 not deceased; MD 0.81 IC95% 0.62-1.0, p= <0.0001, I2=32%). No statistical significance was found for the other clinical variables. Conclusions: Increased MVP is associated with increased risk of mortality in patients with sepsis, especially after 72 hours of evolution of clinical features.",

keywords = "Mean Platelet Volume, Mortality, Sepsis, Systematic Review",

author = "V{\'e}lez-Paez, {Jorge Luis} and Carlos Velarde-Montero and Estefan{\'i}a Irigoyen-Mogro and Pablo V{\'e}lez-P{\'a}ez and Paulina Cifuentes-L{\'o}pez and V{\'e}lez, {Jorge W.} and Leonardo Albitres-Flores and Barboza, {Joshuan J.}",

year = "2020",

doi = "10.22354/in.v24i3.861",

language = "Espa{\~n}ol",

volume = "24",

pages = "162--168",

journal = "Infectio",

issn = "0123-9392",

publisher = "Asociacion Colombiana de Infectologia",

number = "3",

}

TY - JOUR

T1 - Volumen plaquetario medio como predictor de la mortalidad en pacientes con sepsis

T2 - Revisión sistemática y metanálisis

AU - Vélez-Paez, Jorge Luis

AU - Velarde-Montero, Carlos

AU - Irigoyen-Mogro, Estefanía

AU - Vélez-Páez, Pablo

AU - Cifuentes-López, Paulina

AU - Vélez, Jorge W.

AU - Albitres-Flores, Leonardo

AU - Barboza, Joshuan J.

PY - 2020

Y1 - 2020

N2 - Introduction: Platelet mean volume (MVP) is a biomarker used in the integral approach to sepsis. Objective: To assess the association between MVP and mortality in patients with sepsis. Methods: A systematic review of observational studies in five databases was performed. Mortality associated with sepsis was analysed; interventions considered were MPV, APACHE and serum lactate. Results: Regarding mortality associated with sepsis, a significant value was found in the MVP at 72 hours (200 deceased versus 654 not deceased; MD 0.83 IC95% 0.53-1.13, p= <0.0001, I2=72.9%); as well as the value of APACHE II (220 dead versus 604 not deceased; MD 0.81 IC95% 0.62-1.0, p= <0.0001, I2=32%). No statistical significance was found for the other clinical variables. Conclusions: Increased MVP is associated with increased risk of mortality in patients with sepsis, especially after 72 hours of evolution of clinical features.

AB - Introduction: Platelet mean volume (MVP) is a biomarker used in the integral approach to sepsis. Objective: To assess the association between MVP and mortality in patients with sepsis. Methods: A systematic review of observational studies in five databases was performed. Mortality associated with sepsis was analysed; interventions considered were MPV, APACHE and serum lactate. Results: Regarding mortality associated with sepsis, a significant value was found in the MVP at 72 hours (200 deceased versus 654 not deceased; MD 0.83 IC95% 0.53-1.13, p= <0.0001, I2=72.9%); as well as the value of APACHE II (220 dead versus 604 not deceased; MD 0.81 IC95% 0.62-1.0, p= <0.0001, I2=32%). No statistical significance was found for the other clinical variables. Conclusions: Increased MVP is associated with increased risk of mortality in patients with sepsis, especially after 72 hours of evolution of clinical features.

KW - Mean Platelet Volume

KW - Mortality

KW - Sepsis

KW - Systematic Review

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U2 - 10.22354/in.v24i3.861

DO - 10.22354/in.v24i3.861

M3 - Artículo

AN - SCOPUS:85091123415

SN - 0123-9392

VL - 24

SP - 162

EP - 168

JO - Infectio

JF - Infectio

IS - 3

ER -

Volumen plaquetario medio como predictor de la mortalidad en pacientes con sepsis: Revisión sistemática y metanálisis

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