Volumen plaquetario medio como predictor de la mortalidad en pacientes con sepsis: Revisión sistemática y metanálisis

Translated title of the contribution: Mean platelet volume as a predictor of mortality in patients with sepsis: Systematic review and meta-analysis

Jorge Luis Vélez-Paez, Carlos Velarde-Montero, Estefanía Irigoyen-Mogro, Pablo Vélez-Páez, Paulina Cifuentes-López, Jorge W. Vélez, Leonardo Albitres-Flores, Joshuan J. Barboza

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Introduction: Platelet mean volume (MVP) is a biomarker used in the integral approach to sepsis. Objective: To assess the association between MVP and mortality in patients with sepsis. Methods: A systematic review of observational studies in five databases was performed. Mortality associated with sepsis was analysed; interventions considered were MPV, APACHE and serum lactate. Results: Regarding mortality associated with sepsis, a significant value was found in the MVP at 72 hours (200 deceased versus 654 not deceased; MD 0.83 IC95% 0.53-1.13, p= <0.0001, I2=72.9%); as well as the value of APACHE II (220 dead versus 604 not deceased; MD 0.81 IC95% 0.62-1.0, p= <0.0001, I2=32%). No statistical significance was found for the other clinical variables. Conclusions: Increased MVP is associated with increased risk of mortality in patients with sepsis, especially after 72 hours of evolution of clinical features.

Translated title of the contributionMean platelet volume as a predictor of mortality in patients with sepsis: Systematic review and meta-analysis
Original languageSpanish
Pages (from-to)162-168
Number of pages7
JournalInfectio
Volume24
Issue number3
DOIs
StatePublished - 2020

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