TY - JOUR
T1 - Vitamin D, menopause, and aging
T2 - quo vadis?
AU - López-Baena, M. T.
AU - Pérez-Roncero, G. R.
AU - Pérez-López, F. R.
AU - Mezones-Holguín, E.
AU - Chedraui, P.
N1 - Publisher Copyright:
© 2019, © 2019 International Menopause Society.
PY - 2019
Y1 - 2019
N2 - Menopause and aging are associated with changes in circulating gonadal steroid hormones, insulin sensitivity, body composition, and also lifestyle and social coordinates. Vitamin D status influences different metabolic adjustments, aside from calcium–phosphorus and bone metabolism. The main blood marker used to measure endogenous vitamin D status is 25-hydroxyvitamin D. Aging is associated with increases in serum parathyroid hormone and alkaline phosphatase, and a decrease of serum calcium, phosphorus, and vitamin D metabolites. 25-Hydroxyvitamin D status is also influenced by the circannual rhythm of sun irradiation. Results of clinical association studies have not correlated with intervention trials, experimental studies, and/or meta-analyses regarding the role of vitamin D on different outcomes in women during their second half of life and the vitamin D supplementation dose needed to improve clinical endpoints. Discordant results have been related to the method used to measure vitamin D, the studied population (i.e., sociodemographics and ethnicity), study designs, and biases of analyses. Vitamin D supplementation with cholecalciferol or calcifediol may improve some metabolic variables and clinical outcomes in young postmenopausal and older women. Studies seem to suggest that calcifediol may have some advantages over other forms of vitamin D supplementation. Further studies are needed to define interventions with supplements and effective food fortification.
AB - Menopause and aging are associated with changes in circulating gonadal steroid hormones, insulin sensitivity, body composition, and also lifestyle and social coordinates. Vitamin D status influences different metabolic adjustments, aside from calcium–phosphorus and bone metabolism. The main blood marker used to measure endogenous vitamin D status is 25-hydroxyvitamin D. Aging is associated with increases in serum parathyroid hormone and alkaline phosphatase, and a decrease of serum calcium, phosphorus, and vitamin D metabolites. 25-Hydroxyvitamin D status is also influenced by the circannual rhythm of sun irradiation. Results of clinical association studies have not correlated with intervention trials, experimental studies, and/or meta-analyses regarding the role of vitamin D on different outcomes in women during their second half of life and the vitamin D supplementation dose needed to improve clinical endpoints. Discordant results have been related to the method used to measure vitamin D, the studied population (i.e., sociodemographics and ethnicity), study designs, and biases of analyses. Vitamin D supplementation with cholecalciferol or calcifediol may improve some metabolic variables and clinical outcomes in young postmenopausal and older women. Studies seem to suggest that calcifediol may have some advantages over other forms of vitamin D supplementation. Further studies are needed to define interventions with supplements and effective food fortification.
KW - 25-hydroxyvitamin D
KW - aging
KW - calcifediol
KW - cholecalciferol
KW - ergocalciferol
KW - menopause
KW - Vitamin D
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85075127812&origin=inward
UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85075127812&origin=inward
UR - http://www.mendeley.com/research/vitamin-d-menopause-aging-quo-vadis
U2 - 10.1080/13697137.2019.1682543
DO - 10.1080/13697137.2019.1682543
M3 - Scientific review
C2 - 31736391
AN - SCOPUS:85075127812
SN - 1369-7137
VL - 23
SP - 1
EP - 7
JO - Climacteric
JF - Climacteric
IS - 2
ER -