Trombosis mesénterica asociada a infección por Sars-Cov-2

Translated title of the contribution: Mesenteric thrombosis associated with Sars-Cov-2 infection

José Caballero-Alvarado, Ángeles Álvarez Vargas, Irina Huanes Zviaguina, Akemi Iriarte Vargas, Joshuan J. Barboza, Katherine Lozano Peralta

Research output: Contribution to journalReview articlepeer-review

Abstract

COVID-19 disease is mainly characterized by respiratory clinical manifestations, which can be light to very severe; however, there is a group of patients who can present with thromboembolic events in any part of the body. A search of scientific information in three databases, PubMed, Scopus and Web of Science, was carried out with the aim of describing and analyzing the potential causes of mesenteric thrombosis associated with SARSCoV-2 infection, as well as the clinical outcomes of patients who presented and were treated for mesenteric thrombosis during the course of the disease. Different pathophysiological mechanisms of thromboembolic events associated with COVID-19 have been reported, among them the hyper-coagulable state, an increased production of Von Willebrand factor, the expression of angiotensin-converting enzyme 2 in small intestinal enterocytes, which in response to infection can release inflammatory mediators, and the state of shock present in two thirds of critically ill patients. Patients with COVID-19 and especially those with severe stages may have different mechanisms that converge or exacerbate a state of hyper-coagulation, which can affect any part of the body such as the mesenteric vessels and lead to gastrointestinal ischemia that compromises its viability and ends in intestinal resection due to necrosis.

Translated title of the contributionMesenteric thrombosis associated with Sars-Cov-2 infection
Original languageSpanish
Pages (from-to)162-170
Number of pages9
JournalBoletin de Malariologia y Salud Ambiental
Volume62
Issue number2
DOIs
StatePublished - 2022
Externally publishedYes

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