Statin therapy in athletes and patients performing regular intense exercise – Position paper from the International Lipid Expert Panel (ILEP)

Niki Katsiki; Dimitri P. Mikhailidis; Gani Bajraktari; Gani Bajraktari; Gani Bajraktari; Andre R. Miserez; Andre R. Miserez; Arrigo F.G. Cicero; Eric Bruckert; Maria Corina Serban; Erkin Mirrakhimov; Sahebkar Amirhossein; Željko Reiner; György Paragh; Amirhossein Sahebkar; Amirhossein Sahebkar; Amirhossein Sahebkar; Maciej Banach; Maciej Banach; Maciej Banach; Fahad Alnouri; Fahma Amar; Atanas G. Atanasov; Gani Bajraktari; Maciej Banach; Marcin A. Bartlomiejczyk; Bojko Bjelakovic; Eric Bruckert; Agata Bielecka-Dabrowa; Alberto Cafferata; Richard Ceska; Arrigo F.G. Cicero; Xavier Collet; Olivier Descamps; Nair Devaki; Dragan Djuric; Ronen Durst; Marat V. Ezhov; Zlatko Fras; Dan Gaita; Stephan von Haehling; Adrian V. Hernandez; Steven R. Jones; Jacek Jozwiak; Nona Kakauridze; Niki Katsiki; Amit Khera; Karam Kostner; Raimondas Kubilius; Gustavs Latkovskis; G. B.John Mancini; A. David Marais; Seth S. Martin; Julio Acosta Martinez; Mohsen Mazidi; Dimitri P. Mikhailidis; Erkin Mirrakhimov; Andre R. Miserez; Olena Mitchenko; Patrick Moriarty; Seyed Mohammad Nabavi; Demosthenes B. Panagiotakos; György Paragh; Daniel Pella; Peter E. Penson; Zaneta Petrulioniene; Matteo Pirro; Arman Postadzhiyan; Raman Puri; Ashraf Reda; Željko Reiner; Jemaa Riadh; Dimitri Richter; Manfredi Rizzo; Massimiliano Ruscica; Amirhossein Sahebkar; Naveed Sattar; Maria Corina Serban; Abdulla M.A. Shehab; Aleksandr B. Shek; Cesare R. Sirtori; Claudia Stefanutti; Tomasz Tomasik; Peter P. Toth; Margus Viigimaa; Dragos Vinereanu; Branislav Vohnout; Michal Vrablik; Nathan D. Wong; Hung I. Yeh; Jiang Zhisheng; Andreas Zirlik

doi:10.1016/j.phrs.2020.104719

Statin therapy in athletes and patients performing regular intense exercise – Position paper from the International Lipid Expert Panel (ILEP)

Niki Katsiki, Dimitri P. Mikhailidis, Gani Bajraktari, Gani Bajraktari, Gani Bajraktari, Andre R. Miserez, Andre R. Miserez, Arrigo F.G. Cicero, Eric Bruckert, Maria Corina Serban, Erkin Mirrakhimov, Sahebkar Amirhossein, Željko Reiner, György Paragh, Amirhossein Sahebkar, Amirhossein Sahebkar, Amirhossein Sahebkar, Maciej Banach, Maciej Banach, Maciej BanachFahad Alnouri, Fahma Amar, Atanas G. Atanasov, Gani Bajraktari, Maciej Banach, Marcin A. Bartlomiejczyk, Bojko Bjelakovic, Eric Bruckert, Agata Bielecka-Dabrowa, Alberto Cafferata, Richard Ceska, Arrigo F.G. Cicero, Xavier Collet, Olivier Descamps, Nair Devaki, Dragan Djuric, Ronen Durst, Marat V. Ezhov, Zlatko Fras, Dan Gaita, Stephan von Haehling, Adrian V. Hernandez, Steven R. Jones, Jacek Jozwiak, Nona Kakauridze, Niki Katsiki, Amit Khera, Karam Kostner, Raimondas Kubilius, Gustavs Latkovskis, G. B.John Mancini, A. David Marais, Seth S. Martin, Julio Acosta Martinez, Mohsen Mazidi, Dimitri P. Mikhailidis, Erkin Mirrakhimov, Andre R. Miserez, Olena Mitchenko, Patrick Moriarty, Seyed Mohammad Nabavi, Demosthenes B. Panagiotakos, György Paragh, Daniel Pella, Peter E. Penson, Zaneta Petrulioniene, Matteo Pirro, Arman Postadzhiyan, Raman Puri, Ashraf Reda, Željko Reiner, Jemaa Riadh, Dimitri Richter, Manfredi Rizzo, Massimiliano Ruscica, Amirhossein Sahebkar, Naveed Sattar, Maria Corina Serban, Abdulla M.A. Shehab, Aleksandr B. Shek, Cesare R. Sirtori, Claudia Stefanutti, Tomasz Tomasik, Peter P. Toth, Margus Viigimaa, Dragos Vinereanu, Branislav Vohnout, Michal Vrablik, Nathan D. Wong, Hung I. Yeh, Jiang Zhisheng, Andreas Zirlik

Universidad San Ignacio de Loyola

Research output: Contribution to journal › Review article › peer-review

13 Scopus citations

Abstract

Acute and chronic physical exercises may enhance the development of statin-related myopathy. In this context, the recent (2019) guidelines of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS) for the management of dyslipidemias recommend that, although individuals with dyslipidemia should be advised to engage in regular moderate physical exercise (for at least 30 min daily), physicians should be alerted with regard to myopathy and creatine kinase (CK) elevation in statin-treated sport athletes. However it is worth emphasizing that abovementioned guidelines, previous and recent ESC/EAS consensus papers on adverse effects of statin therapy as well as other previous attempts on this issue, including the ones from the International Lipid Expert Panel (ILEP), give only general recommendations on how to manage patients requiring statin therapy on regular exercises. Therefore, these guidelines in the form of the Position Paper are the first such an attempt to summary existing, often scarce knowledge, and to present this important issue in the form of step-by-step practical recommendations. It is critically important as we might observe more and more individuals on regular exercises/athletes requiring statin therapy due to their cardiovascular risk.

Original language	American English
Article number	104719
Journal	Pharmacological Research
Volume	155
DOIs	https://doi.org/10.1016/j.phrs.2020.104719
State	Published - 1 May 2020

Keywords

Athleths
Exercises
Management
Mylagia
Statin intolerance

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10.1016/j.phrs.2020.104719

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Katsiki, N., Mikhailidis, D. P., Bajraktari, G., Bajraktari, G., Bajraktari, G., Miserez, A. R., Miserez, A. R., Cicero, A. F. G., Bruckert, E., Serban, M. C., Mirrakhimov, E., Amirhossein, S., Reiner, Ž., Paragh, G., Sahebkar, A., Sahebkar, A., Sahebkar, A., Banach, M., Banach, M., ... Zirlik, A. (2020). Statin therapy in athletes and patients performing regular intense exercise – Position paper from the International Lipid Expert Panel (ILEP). Pharmacological Research, 155, Article 104719. https://doi.org/10.1016/j.phrs.2020.104719

@article{54720133c1844e2380b9462342c020ba,

title = "Statin therapy in athletes and patients performing regular intense exercise – Position paper from the International Lipid Expert Panel (ILEP)",

abstract = "Acute and chronic physical exercises may enhance the development of statin-related myopathy. In this context, the recent (2019) guidelines of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS) for the management of dyslipidemias recommend that, although individuals with dyslipidemia should be advised to engage in regular moderate physical exercise (for at least 30 min daily), physicians should be alerted with regard to myopathy and creatine kinase (CK) elevation in statin-treated sport athletes. However it is worth emphasizing that abovementioned guidelines, previous and recent ESC/EAS consensus papers on adverse effects of statin therapy as well as other previous attempts on this issue, including the ones from the International Lipid Expert Panel (ILEP), give only general recommendations on how to manage patients requiring statin therapy on regular exercises. Therefore, these guidelines in the form of the Position Paper are the first such an attempt to summary existing, often scarce knowledge, and to present this important issue in the form of step-by-step practical recommendations. It is critically important as we might observe more and more individuals on regular exercises/athletes requiring statin therapy due to their cardiovascular risk.",

keywords = "Athleths, Exercises, Management, Mylagia, Statin intolerance",

author = "Niki Katsiki and Mikhailidis, {Dimitri P.} and Gani Bajraktari and Gani Bajraktari and Gani Bajraktari and Miserez, {Andre R.} and Miserez, {Andre R.} and Cicero, {Arrigo F.G.} and Eric Bruckert and Serban, {Maria Corina} and Erkin Mirrakhimov and Sahebkar Amirhossein and {\v Z}eljko Reiner and Gy{\"o}rgy Paragh and Amirhossein Sahebkar and Amirhossein Sahebkar and Amirhossein Sahebkar and Maciej Banach and Maciej Banach and Maciej Banach and Fahad Alnouri and Fahma Amar and Atanasov, {Atanas G.} and Gani Bajraktari and Maciej Banach and Bartlomiejczyk, {Marcin A.} and Bojko Bjelakovic and Eric Bruckert and Agata Bielecka-Dabrowa and Alberto Cafferata and Richard Ceska and Cicero, {Arrigo F.G.} and Xavier Collet and Olivier Descamps and Nair Devaki and Dragan Djuric and Ronen Durst and Ezhov, {Marat V.} and Zlatko Fras and Dan Gaita and {von Haehling}, Stephan and Hernandez, {Adrian V.} and Jones, {Steven R.} and Jacek Jozwiak and Nona Kakauridze and Niki Katsiki and Amit Khera and Karam Kostner and Raimondas Kubilius and Gustavs Latkovskis and Mancini, {G. B.John} and Marais, {A. David} and Martin, {Seth S.} and Martinez, {Julio Acosta} and Mohsen Mazidi and Mikhailidis, {Dimitri P.} and Erkin Mirrakhimov and Miserez, {Andre R.} and Olena Mitchenko and Patrick Moriarty and Nabavi, {Seyed Mohammad} and Panagiotakos, {Demosthenes B.} and Gy{\"o}rgy Paragh and Daniel Pella and Penson, {Peter E.} and Zaneta Petrulioniene and Matteo Pirro and Arman Postadzhiyan and Raman Puri and Ashraf Reda and {\v Z}eljko Reiner and Jemaa Riadh and Dimitri Richter and Manfredi Rizzo and Massimiliano Ruscica and Amirhossein Sahebkar and Naveed Sattar and Serban, {Maria Corina} and Shehab, {Abdulla M.A.} and Shek, {Aleksandr B.} and Sirtori, {Cesare R.} and Claudia Stefanutti and Tomasz Tomasik and Toth, {Peter P.} and Margus Viigimaa and Dragos Vinereanu and Branislav Vohnout and Michal Vrablik and Wong, {Nathan D.} and Yeh, {Hung I.} and Jiang Zhisheng and Andreas Zirlik",

year = "2020",

month = may,

day = "1",

doi = "10.1016/j.phrs.2020.104719",

language = "American English",

volume = "155",

journal = "Pharmacological Research",

issn = "1043-6618",

publisher = "Elsevier BV",

}

Katsiki, N, Mikhailidis, DP, Bajraktari, G, Bajraktari, G, Bajraktari, G, Miserez, AR, Miserez, AR, Cicero, AFG, Bruckert, E, Serban, MC, Mirrakhimov, E, Amirhossein, S, Reiner, Ž, Paragh, G, Sahebkar, A, Sahebkar, A, Sahebkar, A, Banach, M, Banach, M, Banach, M, Alnouri, F, Amar, F, Atanasov, AG, Bajraktari, G, Banach, M, Bartlomiejczyk, MA, Bjelakovic, B, Bruckert, E, Bielecka-Dabrowa, A, Cafferata, A, Ceska, R, Cicero, AFG, Collet, X, Descamps, O, Devaki, N, Djuric, D, Durst, R, Ezhov, MV, Fras, Z, Gaita, D, von Haehling, S, Hernandez, AV, Jones, SR, Jozwiak, J, Kakauridze, N, Katsiki, N, Khera, A, Kostner, K, Kubilius, R, Latkovskis, G, Mancini, GBJ, Marais, AD, Martin, SS, Martinez, JA, Mazidi, M, Mikhailidis, DP, Mirrakhimov, E, Miserez, AR, Mitchenko, O, Moriarty, P, Nabavi, SM, Panagiotakos, DB, Paragh, G, Pella, D, Penson, PE, Petrulioniene, Z, Pirro, M, Postadzhiyan, A, Puri, R, Reda, A, Reiner, Ž, Riadh, J, Richter, D, Rizzo, M, Ruscica, M, Sahebkar, A, Sattar, N, Serban, MC, Shehab, AMA, Shek, AB, Sirtori, CR, Stefanutti, C, Tomasik, T, Toth, PP, Viigimaa, M, Vinereanu, D, Vohnout, B, Vrablik, M, Wong, ND, Yeh, HI, Zhisheng, J & Zirlik, A 2020, 'Statin therapy in athletes and patients performing regular intense exercise – Position paper from the International Lipid Expert Panel (ILEP)', Pharmacological Research, vol. 155, 104719. https://doi.org/10.1016/j.phrs.2020.104719

TY - JOUR

T1 - Statin therapy in athletes and patients performing regular intense exercise – Position paper from the International Lipid Expert Panel (ILEP)

AU - Katsiki, Niki

AU - Mikhailidis, Dimitri P.

AU - Bajraktari, Gani

AU - Miserez, Andre R.

AU - Cicero, Arrigo F.G.

AU - Bruckert, Eric

AU - Serban, Maria Corina

AU - Mirrakhimov, Erkin

AU - Amirhossein, Sahebkar

AU - Reiner, Željko

AU - Paragh, György

AU - Sahebkar, Amirhossein

AU - Banach, Maciej

AU - Alnouri, Fahad

AU - Amar, Fahma

AU - Atanasov, Atanas G.

AU - Bajraktari, Gani

AU - Banach, Maciej

AU - Bartlomiejczyk, Marcin A.

AU - Bjelakovic, Bojko

AU - Bruckert, Eric

AU - Bielecka-Dabrowa, Agata

AU - Cafferata, Alberto

AU - Ceska, Richard

AU - Cicero, Arrigo F.G.

AU - Collet, Xavier

AU - Descamps, Olivier

AU - Devaki, Nair

AU - Djuric, Dragan

AU - Durst, Ronen

AU - Ezhov, Marat V.

AU - Fras, Zlatko

AU - Gaita, Dan

AU - von Haehling, Stephan

AU - Hernandez, Adrian V.

AU - Jones, Steven R.

AU - Jozwiak, Jacek

AU - Kakauridze, Nona

AU - Katsiki, Niki

AU - Khera, Amit

AU - Kostner, Karam

AU - Kubilius, Raimondas

AU - Latkovskis, Gustavs

AU - Mancini, G. B.John

AU - Marais, A. David

AU - Martin, Seth S.

AU - Martinez, Julio Acosta

AU - Mazidi, Mohsen

AU - Mikhailidis, Dimitri P.

AU - Mirrakhimov, Erkin

AU - Miserez, Andre R.

AU - Mitchenko, Olena

AU - Moriarty, Patrick

AU - Nabavi, Seyed Mohammad

AU - Panagiotakos, Demosthenes B.

AU - Paragh, György

AU - Pella, Daniel

AU - Penson, Peter E.

AU - Petrulioniene, Zaneta

AU - Pirro, Matteo

AU - Postadzhiyan, Arman

AU - Puri, Raman

AU - Reda, Ashraf

AU - Reiner, Željko

AU - Riadh, Jemaa

AU - Richter, Dimitri

AU - Rizzo, Manfredi

AU - Ruscica, Massimiliano

AU - Sahebkar, Amirhossein

AU - Sattar, Naveed

AU - Serban, Maria Corina

AU - Shehab, Abdulla M.A.

AU - Shek, Aleksandr B.

AU - Sirtori, Cesare R.

AU - Stefanutti, Claudia

AU - Tomasik, Tomasz

AU - Toth, Peter P.

AU - Viigimaa, Margus

AU - Vinereanu, Dragos

AU - Vohnout, Branislav

AU - Vrablik, Michal

AU - Wong, Nathan D.

AU - Yeh, Hung I.

AU - Zhisheng, Jiang

AU - Zirlik, Andreas

PY - 2020/5/1

Y1 - 2020/5/1

N2 - Acute and chronic physical exercises may enhance the development of statin-related myopathy. In this context, the recent (2019) guidelines of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS) for the management of dyslipidemias recommend that, although individuals with dyslipidemia should be advised to engage in regular moderate physical exercise (for at least 30 min daily), physicians should be alerted with regard to myopathy and creatine kinase (CK) elevation in statin-treated sport athletes. However it is worth emphasizing that abovementioned guidelines, previous and recent ESC/EAS consensus papers on adverse effects of statin therapy as well as other previous attempts on this issue, including the ones from the International Lipid Expert Panel (ILEP), give only general recommendations on how to manage patients requiring statin therapy on regular exercises. Therefore, these guidelines in the form of the Position Paper are the first such an attempt to summary existing, often scarce knowledge, and to present this important issue in the form of step-by-step practical recommendations. It is critically important as we might observe more and more individuals on regular exercises/athletes requiring statin therapy due to their cardiovascular risk.

AB - Acute and chronic physical exercises may enhance the development of statin-related myopathy. In this context, the recent (2019) guidelines of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS) for the management of dyslipidemias recommend that, although individuals with dyslipidemia should be advised to engage in regular moderate physical exercise (for at least 30 min daily), physicians should be alerted with regard to myopathy and creatine kinase (CK) elevation in statin-treated sport athletes. However it is worth emphasizing that abovementioned guidelines, previous and recent ESC/EAS consensus papers on adverse effects of statin therapy as well as other previous attempts on this issue, including the ones from the International Lipid Expert Panel (ILEP), give only general recommendations on how to manage patients requiring statin therapy on regular exercises. Therefore, these guidelines in the form of the Position Paper are the first such an attempt to summary existing, often scarce knowledge, and to present this important issue in the form of step-by-step practical recommendations. It is critically important as we might observe more and more individuals on regular exercises/athletes requiring statin therapy due to their cardiovascular risk.

KW - Athleths

KW - Exercises

KW - Management

KW - Mylagia

KW - Statin intolerance

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U2 - 10.1016/j.phrs.2020.104719

DO - 10.1016/j.phrs.2020.104719

M3 - Review article

SN - 1043-6618

VL - 155

JO - Pharmacological Research

JF - Pharmacological Research

M1 - 104719

ER -

Statin therapy in athletes and patients performing regular intense exercise – Position paper from the International Lipid Expert Panel (ILEP)

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Keywords

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