State of art of cancer pharmacogenomics in Latin American populations

Angel Tito Alvarado, Andrés López-Cortés, Santiago Guerrero, María Ana Redal, Luis Abel Quiñones

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations

Abstract

© 2017 by the authors. Licensee MDPI, Basel, Switzerland. Over the past decades, several studies have shown that tumor-related somatic and germline alterations predicts tumor prognosis, drug response and toxicity. Latin American populations present a vast geno-phenotypic diversity due to the great interethnic and interracial mixing. This genetic flow leads to the appearance of complex characteristics that allow individuals to adapt to endemic environments, such as high altitude or extreme tropical weather. These genetic changes, most of them subtle and unexplored, could establish a mutational profile to develop new pharmacogenomic therapies specific for Latin American populations. In this review, we present the current status of research on somatic and germline alterations in Latin America compared to those found in Caucasian and Asian populations.
Original languageAmerican English
Article number639
JournalInternational Journal of Molecular Sciences
Volume18
Issue number6
DOIs
StatePublished - Jun 2017
Externally publishedYes

Keywords

  • Cancer
  • Latin America
  • Pharmacogenetics
  • Pharmacogenomics
  • Precision medicine
  • Single nucleotide polymorphism

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