Prognostic Value of Frailty in Patients With Takotsubo Cardiomyopathy

Carlos Diaz-Arocutipa*, Adrian V. Hernandez

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Background: There is scarce data on the prognostic value of frailty in patients with Takotsubo cardiomyopathy (TCM). This study aimed to assess the association between frailty and in-hospital outcomes in patients with TCM. Methods: Adult admissions with TCM were included using the 2016−2019 National Inpatient Sample database. The primary outcome was in-hospital mortality and secondary outcomes included cardiogenic shock, in-hospital cardiac arrest, stroke/transient ischemic attack (TIA), length of hospital stay, and total charges. Frailty was assessed using the hospital frailty risk score (HFRS), and admissions were divided into two groups: low risk and intermediate/high risk of frailty. Logistic regression was used to estimate odds ratios (OR) with their 95% confidence intervals (CI). Results: A total of 32 360 patients were included; the median age was 67 (58−76) years and 90% were female. The median HFRS was 2.6 (1.1−5.3). In the adjusted models, in-hospital mortality was significantly higher in the intermediate/high risk of frailty group (OR 3.60, 95% CI 2.16−6.02) compared to the low-risk group. Similarly, admissions with intermediate/high risk of frailty had a significantly higher risk of cardiogenic shock (OR 3.66, 95% CI 2.77−4.80), in-hospital cardiac arrest (OR 2.57, 95% CI 1.55−4.24), and stroke/TIA (OR 5.68, 95% CI 3.51−9.20). There was a significantly higher hospital charges and length of hospital stay in the intermediate/high-risk group. In the restricted cubic spline regression models, the frailty score was nonlinearly associated with all outcomes. Conclusions: Our results suggest that frailty is useful as a prognostic factor for in-hospital events in patients with TCM.

Original languageEnglish
Article numbere70054
JournalClinical Cardiology
Volume48
Issue number1
DOIs
StatePublished - Jan 2025

Keywords

  • frailty
  • mortality
  • NIS
  • prognosis
  • Takotsubo cardiomyopathy

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