Phylogenomics reveals multiple introductions and early spread of SARS-CoV-2 into Peru

Eduardo Juscamayta-López, Dennis Carhuaricra, David Tarazona, Faviola Valdivia, Nancy Rojas, Lenin Maturrano, Ronnie Gavilán

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Peru has become one of the countries with the highest mortality rates from the current coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). To investigate early transmission events and the genomic diversity of SARS-CoV-2 isolates circulating in Peru in the early COVID-19 pandemic, we analyzed 3472 viral genomes, of which 149 were from Peru. Phylogenomic analysis revealed multiple and independent introductions of the virus likely from Europe and Asia and a high diversity of genetic lineages circulating in Peru. In addition, we found evidence for community-driven transmission of SARS-CoV-2 as suggested by clusters of related viruses found in patients living in different regions of Peru.

Original languageEnglish
Pages (from-to)5961-5968
Number of pages8
JournalJournal of Medical Virology
Volume93
Issue number10
DOIs
StatePublished - Oct 2021
Externally publishedYes

Keywords

  • SARS-CoV-2
  • evolution
  • molecular epidemiology
  • phylogenomics
  • transmission
  • whole-genome sequencing

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