Periodontitis and Neuropathic Diseases: A Literature Review

Jesus Cabanillas, Ruth Risco, Arnaldo Munive-Degregori, Maria Eugenia Guerrero, Franco Mauricio, Frank Mayta-Tovalino*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Aim: This narrative review aimed at identifying the existing scientific literature investigating periodontitis and neuropathic diseases. Materials and Methods: A search of the literature published between 2000 and 2022 was carried out in the electronic databases of Scopus and PubMed. Studies in which the eligible articles were mainly published in English were included. Descriptive correlational studies, case-control studies, comparative studies, and cohort studies were also included. The following main keywords were used: “Neuropathic diseases,” “Periodontitis,” “Alzheimer's disease,” and “Porphyromonas gingivalis.” Results: This narrative review found that cognitively impaired persons with severe periodontitis had a higher prevalence and incidence of periodontal diseases than the rest of the population. A significant positive correlation of salivary interleukin (IL)-1beta and immediate recall scores involved in cognition was also evident. It indicates that the most investigated parameter was whether there is any common link between periodontal disease and neurodegeneration. No randomized controlled clinical studies were found in the current literature review. Conclusions: Based on the literature reviewed, there is currently no strong scientific evidence to support or discourage the cause-effect relationship of periodontal diseases and neurodegenerative diseases.

Original languageEnglish
Pages (from-to)10-15
Number of pages6
JournalJournal of International Society of Preventive and Community Dentistry
Issue number1
StatePublished - Jan 2024
Externally publishedYes


  • Neuropathic diseases
  • periodontitis
  • review


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