Pericarditis in patients with COVID-19: A systematic review

Carlos Diaz-Arocutipa, Jose Saucedo-Chinchay, Massimo Imazio

Research output: Contribution to journalArticlepeer-review

39 Scopus citations


AimsWe performed a systematic review to summarize the clinical features, diagnostic methods, treatment, and outcomes of coronavirus disease 2019 (COVID-19) patients with pericarditis.MethodsWe searched electronic databases from inception to 17 December 2020. Studies that reported clinical data on patients with COVID-19 and pericarditis were included. Descriptive statistics were used for categorical and continuous variables [mean ± standard deviation or median (interquartile range)]. As an exploratory analysis, differences between patients with acute pericarditis and myopericarditis were compared.ResultsA total of 33 studies (32 case reports and 1 case series) involving 34 patients were included. The mean age was 51.6 ± 19.5 years and 62% of patients were men. Sixty-Two percentage of patients were diagnosed with myopericarditis. The most frequent electrocardiographic pattern (56%) was diffuse ST-elevation and PR depression. Pericardial effusion and cardiac tamponade were reported in 76 and 35% of cases, respectively. The median values of C-reactive protein [77 mg/dl (12-177)] and white blood cells [12 335 cells/μl (5625-16 500)] were above the normal range. Thirty-eight percent and 53% of patients were treated with nonsteroidal anti-inflammatory drugs (NSAIDs) and colchicine, respectively. These drugs were more frequently used in patients with acute pericarditis compared with myopericarditis. The in-hospital mortality was 6% without a significant difference between both groups.ConclusionOur review shows that COVID-19 patients with pericarditis had similar clinical features to other viral cardiotropic infections. However, NSAIDs and colchicine were used in half or less of the cases. Overall, the short-Term prognosis was good across groups.

Original languageEnglish
Pages (from-to)693-700
Number of pages8
JournalJournal of Cardiovascular Medicine
Issue number9
StatePublished - 1 Sep 2021


  • COVID-19/complications
  • Case-Control Studies
  • Female
  • Humans
  • Male
  • Middle Aged
  • Patient Care Management/methods
  • Pericarditis/diagnosis
  • Prognosis
  • SARS-CoV-2/isolation & purification


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