TY - JOUR
T1 - Myocarditis manifestations in dengue cases
T2 - A systematic review and meta-analysis
AU - Sandeep, Mokanpally
AU - Padhi, Bijaya K.
AU - Yella, Sree Sudha Tanguturi
AU - Sruthi, K. G.
AU - Venkatesan, Raghul Gandhi
AU - Krishna Sasanka, KS B.S.
AU - Satapathy, Prakasini
AU - Mohanty, Aroop
AU - Al-Tawfiq, Jaffar A.
AU - Iqhrammullah, Muhammad
AU - Rabaan, Ali A.
AU - Kabi, Ankita
AU - Sah, Sanjit
AU - Rustagi, Sarvesh
AU - Al-qaim, Zahraa Haleem
AU - Barboza, Joshuan J.
AU - Waheed, Yasir
AU - Harapan, Harapan
AU - Sah, Ranjit
N1 - Publisher Copyright:
© 2023 The Author(s)
PY - 2023/11
Y1 - 2023/11
N2 - Background: Dengue fever is a zoonotic viral infection that raises a global alarm in the tropics and subtropics, with the potentially escalating into newer geographical regions. Severe dengue may be associated with fatal complications such as myocarditis. There is a paucity of available data on the prevalence of dengue-associated myocarditis. The objective of this systematic review and meta-analysis was to estimate the global prevalence of dengue-associated myocarditis. Methods: A systematic search was conducted utilizing the Cochrane library, PubMed, Scopus, ProQuest, Web of Science, and Preprint servers such as arXiv, medRxiv, bioRxiv, BioRN, ChiRN, ChiRxiv, and SSRN as of November 25, 2022. All primary studies (case series, cross-sectional, retrospective, and prospective) that reported confirmed cases of dengue myocarditis were included. The I2 statistic test assessed the heterogenic characteristics and publication bias was evaluated using Doi plot and Egger regression tests. Results: A total of 12 studies conducted between 2007 and 2022 with 2795 laboratory-confirmed dengue patients were included. Of the included cases, 502 were positive for myocarditis, with a prevalence of 2.4–78%. The pooled prevalence of dengue-induced myocarditis in the studied population was 21.0% (95% CI, 9 – 38%). The prediction interval was estimated to be 0.00 - 0.81. Conclusion: Myocarditis in dengue patients is a significant and understudied complication in many aspects. To prevent dengue-associated myocarditis, appropriate measures such as early detection of cases and signs, symptoms-based diagnosis via electrocardiography and echocardiography, as well as relevant vector control policies must be implemented.
AB - Background: Dengue fever is a zoonotic viral infection that raises a global alarm in the tropics and subtropics, with the potentially escalating into newer geographical regions. Severe dengue may be associated with fatal complications such as myocarditis. There is a paucity of available data on the prevalence of dengue-associated myocarditis. The objective of this systematic review and meta-analysis was to estimate the global prevalence of dengue-associated myocarditis. Methods: A systematic search was conducted utilizing the Cochrane library, PubMed, Scopus, ProQuest, Web of Science, and Preprint servers such as arXiv, medRxiv, bioRxiv, BioRN, ChiRN, ChiRxiv, and SSRN as of November 25, 2022. All primary studies (case series, cross-sectional, retrospective, and prospective) that reported confirmed cases of dengue myocarditis were included. The I2 statistic test assessed the heterogenic characteristics and publication bias was evaluated using Doi plot and Egger regression tests. Results: A total of 12 studies conducted between 2007 and 2022 with 2795 laboratory-confirmed dengue patients were included. Of the included cases, 502 were positive for myocarditis, with a prevalence of 2.4–78%. The pooled prevalence of dengue-induced myocarditis in the studied population was 21.0% (95% CI, 9 – 38%). The prediction interval was estimated to be 0.00 - 0.81. Conclusion: Myocarditis in dengue patients is a significant and understudied complication in many aspects. To prevent dengue-associated myocarditis, appropriate measures such as early detection of cases and signs, symptoms-based diagnosis via electrocardiography and echocardiography, as well as relevant vector control policies must be implemented.
KW - Cardiac dysfunction
KW - Cardiovascular complications
KW - Dengue
KW - Echocardiography
KW - Global prevalence
KW - Myocarditis
KW - Viral infection
UR - http://www.scopus.com/inward/record.url?scp=85172172572&partnerID=8YFLogxK
U2 - 10.1016/j.jiph.2023.08.005
DO - 10.1016/j.jiph.2023.08.005
M3 - Artículo
C2 - 37738692
AN - SCOPUS:85172172572
SN - 1876-0341
VL - 16
SP - 1761
EP - 1768
JO - Journal of Infection and Public Health
JF - Journal of Infection and Public Health
IS - 11
ER -
