TY - JOUR
T1 - Modulation of the cognitive event-related potential P3 by transcranial direct current stimulation
T2 - Systematic review and meta-analysis
AU - Mendes, Augusto J.
AU - Pacheco-Barrios, Kevin
AU - Lema, Alberto
AU - Gonçalves, Óscar F.
AU - Fregni, Felipe
AU - Leite, Jorge
AU - Carvalho, Sandra
N1 - Publisher Copyright:
© 2021 Elsevier Ltd
PY - 2021
Y1 - 2021
N2 - Transcranial direct current stimulation (tDCS) has been widely used to modulate cognition and behavior. However, only a few studies have been probing the brain mechanism underlying the effects of tDCS on cognitive processing, especially throughout electrophysiological markers, such as the P3. This meta-analysis assessed the effects of tDCS in P3 amplitude and latency during an oddball, n-back, and Go/No-Go tasks, as well as during emotional processing. A total of 36 studies were identified, but only 23 were included in the quantitative analysis. The results show that the parietal P3 amplitude increased during oddball and n-back tasks, mostly after anodal stimulation over the left dorsolateral prefrontal cortex (p = 0.018, SMD = 0.4) and right inferior frontal gyrus (p < 0.001, SMD = 0.669) respectively. These findings suggest the potential usefulness of the parietal P3 ERP as a marker of tDCS-induced effects during task performance. Nonetheless, this study had a low number of studies and the presence of considerable risk of bias, highlighting issues to be addressed in the future.
AB - Transcranial direct current stimulation (tDCS) has been widely used to modulate cognition and behavior. However, only a few studies have been probing the brain mechanism underlying the effects of tDCS on cognitive processing, especially throughout electrophysiological markers, such as the P3. This meta-analysis assessed the effects of tDCS in P3 amplitude and latency during an oddball, n-back, and Go/No-Go tasks, as well as during emotional processing. A total of 36 studies were identified, but only 23 were included in the quantitative analysis. The results show that the parietal P3 amplitude increased during oddball and n-back tasks, mostly after anodal stimulation over the left dorsolateral prefrontal cortex (p = 0.018, SMD = 0.4) and right inferior frontal gyrus (p < 0.001, SMD = 0.669) respectively. These findings suggest the potential usefulness of the parietal P3 ERP as a marker of tDCS-induced effects during task performance. Nonetheless, this study had a low number of studies and the presence of considerable risk of bias, highlighting issues to be addressed in the future.
KW - Attention
KW - Cognition
KW - Event-related potential P3 P300
KW - Inhibitory control
KW - Working memory
KW - tDCS
UR - http://www.scopus.com/inward/record.url?scp=85119208105&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/1198b195-1afc-3ef6-b217-bde21260136a/
U2 - 10.1016/j.neubiorev.2021.11.002
DO - 10.1016/j.neubiorev.2021.11.002
M3 - Artículo de revisión
AN - SCOPUS:85119208105
SN - 0149-7634
VL - 132
SP - 894
EP - 907
JO - Neuroscience and Biobehavioral Reviews
JF - Neuroscience and Biobehavioral Reviews
ER -