Mapping of somatostatin-28 (1-12) in the alpaca (Lama pacos) brainstem

Eliana De Souza, Manuel Lisardo Sánchez, Luís Ángel Aguilar, Zaida Díaz-Cabiale, José Ángel Narváez, Rafael Coveñas

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Using an indirect immunoperoxidase technique, we studied the distribution of cell bodies and fibers containing somatostatin-28 (1-12) in the alpaca brainstem. Immunoreactive fibers were widely distributed throughout the whole brainstem: 34 brainstem nuclei/regions showed a high or a moderate density of these fibers. Perikarya containing the peptide were widely distributed throughout the mesencephalon, pons and medulla oblongata. Cell bodies containing somatostatin-28 (1-12) were observed in the lateral and medial divisions of the marginal nucleus of the brachium conjunctivum, reticular formation (mesencephalon, pons and medulla oblongata), inferior colliculus, periaqueductal gray, superior colliculus, pericentral division of the dorsal tegmental nucleus, interpeduncular nucleus, nucleus of the trapezoid body, vestibular nucleus, motor dorsal nucleus of the vagus, nucleus of the solitary tract, nucleus praepositus hypoglossi, and in the substantia nigra. This widespread distribution indicates that somatostatin-28 (1-12) is involved in multiple physiological actions in the alpaca brainstem.

Original languageEnglish
Pages (from-to)363-374
Number of pages12
JournalMicroscopy Research and Technique
Issue number5
StatePublished - 1 May 2015
Externally publishedYes


  • Camelids
  • Immunocytochemistry
  • Medulla oblongata
  • Mesencephalon
  • Pons


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