TY - JOUR
T1 - Lymphocyte-to-Monocyte Ratio and Clinical Outcomes in Cholangiocarcinoma
T2 - A Systematic Review and Meta-Analysis
AU - Dotto-Vasquez, Giuseppe
AU - Villacorta-Ampuero, Andrea K.
AU - Ulloque-Badaracco, Juan R.
AU - Hernandez-Bustamante, Enrique A.
AU - Alarcón-Braga, Esteban A.
AU - Herrera-Añazco, Percy
AU - Benites-Zapata, Vicente A.
AU - Hernandez, Adrian V.
N1 - Publisher Copyright:
© 2022 by the authors.
PY - 2022/11
Y1 - 2022/11
N2 - Lymphocyte-to-Monocyte ratio (LMR) has shown an association with survival outcomes in several oncological diseases. This study aimed to evaluate the association between LMR and clinical outcomes for cholangiocarcinoma patients. A systematic review and meta-analysis were performed to assess the association between LMR values and overall survival (OS), disease-free survival (DFS), recurrence-free survival (RFS) and time to recurrence (TTR) in cholangiocarcinoma patients. We used Hazard ratio (HR) and their 95% confidence interval (CI) as a measure of effect for the random effect model meta-analysis. The Newcastle–Ottawa Scale was used for quality assessment. The Egger test and funnel plot were developed for approaching publication bias. A total of 19 studies were included in this study (n = 3860). The meta-analysis showed that cholangiocarcinoma patients with low values of LMR were associated with worse OS (HR: 0.82; 95% CI: 0.71–0.96; I2 = 86%) and worse TTR (HR: 0.71; 95% CI: 0.58–0.86; I2 = 0%). DFS and RFS also were evaluated; however, they did not show statistically significant associations. Low LMR values were associated with a worse OS and TTR.
AB - Lymphocyte-to-Monocyte ratio (LMR) has shown an association with survival outcomes in several oncological diseases. This study aimed to evaluate the association between LMR and clinical outcomes for cholangiocarcinoma patients. A systematic review and meta-analysis were performed to assess the association between LMR values and overall survival (OS), disease-free survival (DFS), recurrence-free survival (RFS) and time to recurrence (TTR) in cholangiocarcinoma patients. We used Hazard ratio (HR) and their 95% confidence interval (CI) as a measure of effect for the random effect model meta-analysis. The Newcastle–Ottawa Scale was used for quality assessment. The Egger test and funnel plot were developed for approaching publication bias. A total of 19 studies were included in this study (n = 3860). The meta-analysis showed that cholangiocarcinoma patients with low values of LMR were associated with worse OS (HR: 0.82; 95% CI: 0.71–0.96; I2 = 86%) and worse TTR (HR: 0.71; 95% CI: 0.58–0.86; I2 = 0%). DFS and RFS also were evaluated; however, they did not show statistically significant associations. Low LMR values were associated with a worse OS and TTR.
KW - cholangiocarcinoma
KW - lymphocyte–monocyte ratio
KW - meta-analysis
KW - survival
UR - http://www.scopus.com/inward/record.url?scp=85141721007&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/3928d942-4b5d-34f4-866d-10dcebae447c/
U2 - 10.3390/diagnostics12112655
DO - 10.3390/diagnostics12112655
M3 - Artículo de revisión
AN - SCOPUS:85141721007
SN - 2075-4418
VL - 12
JO - Diagnostics
JF - Diagnostics
IS - 11
M1 - 2655
ER -