Hyperferritinemic sepsis secondary to invasive Toxoplasma gondii in a child with untreated HIV

Jesús Domínguez-Rojas, Jackeline Caute-Lara, Patrick Caqui-Vilca, Mario Cruz-Arpi, Carlos Martel-Ramírez, Miguel Quispe-Chipana, Abel Sánchez-Rodríguez, Noé Atamari-Anahui*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Untreated human immunodeficiency virus (HIV)-immunosuppressed pediatric patients show high morbidity and mortality from opportunistic infections. Limited cases of hyperferritinemic sepsis have been described in patients with toxoplasmosis. Case report: We describe the case of a 13-year-old female patient with a history of untreated HIV who presented with hyperferritinemic sepsis secondary to Toxoplasma gondii infection and Pneumocystis jirovecci pneumonia. She received ventilatory support, inotropic drugs, treatment for opportunistic germs, and high-dose corticosteroids, but with unfavorable evolution. Conclusions: The global approach to sepsis with elevated ferritin guides to using of therapies aimed at neutralizing the severe inflammatory response. A timely diagnosis would allow prompt treatment and minimize complications.

Translated title of the contributionSepsis hiperferritinémica secundaria a Toxoplasma gondii invasiva en un paciente pediátrico con virus de inmunodeficiencia humana sin tratamiento
Original languageEnglish
Pages (from-to)7-11
Number of pages5
JournalBoletin Medico del Hospital Infantil de Mexico
Volume80
DOIs
StatePublished - Jul 2023

Keywords

  • Child
  • Ferritin
  • Hemophagocytic
  • Human immunodeficiency virus
  • Lymphohistiocytosis
  • Sepsis

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