Hyperferritinemic sepsis secondary to invasive Toxoplasma gondii in a child with untreated HIV

Jesús Domínguez-Rojas; Jackeline Caute-Lara; Patrick Caqui-Vilca; Mario Cruz-Arpi; Carlos Martel-Ramírez; Miguel Quispe-Chipana; Abel Sánchez-Rodríguez; Noé Atamari-Anahui

doi:10.24875/BMHIM.22000051

Hyperferritinemic sepsis secondary to invasive Toxoplasma gondii in a child with untreated HIV

Jesús Domínguez-Rojas, Jackeline Caute-Lara, Patrick Caqui-Vilca, Mario Cruz-Arpi, Carlos Martel-Ramírez, Miguel Quispe-Chipana, Abel Sánchez-Rodríguez, Noé Atamari-Anahui

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Untreated human immunodeficiency virus (HIV)-immunosuppressed pediatric patients show high morbidity and mortality from opportunistic infections. Limited cases of hyperferritinemic sepsis have been described in patients with toxoplasmosis. Case report: We describe the case of a 13-year-old female patient with a history of untreated HIV who presented with hyperferritinemic sepsis secondary to Toxoplasma gondii infection and Pneumocystis jirovecci pneumonia. She received ventilatory support, inotropic drugs, treatment for opportunistic germs, and high-dose corticosteroids, but with unfavorable evolution. Conclusions: The global approach to sepsis with elevated ferritin guides to using of therapies aimed at neutralizing the severe inflammatory response. A timely diagnosis would allow prompt treatment and minimize complications.

Translated title of the contribution	Sepsis hiperferritinémica secundaria a Toxoplasma gondii invasiva en un paciente pediátrico con virus de inmunodeficiencia humana sin tratamiento
Original language	English
Pages (from-to)	7-11
Number of pages	5
Journal	Boletin Medico del Hospital Infantil de Mexico
Volume	80
DOIs	https://doi.org/10.24875/BMHIM.22000051
State	Published - Jul 2023

Keywords

Child
Ferritin
Hemophagocytic
Human immunodeficiency virus
Lymphohistiocytosis
Sepsis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.24875/BMHIM.22000051

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title = "Hyperferritinemic sepsis secondary to invasive Toxoplasma gondii in a child with untreated HIV",

abstract = "Background: Untreated human immunodeficiency virus (HIV)-immunosuppressed pediatric patients show high morbidity and mortality from opportunistic infections. Limited cases of hyperferritinemic sepsis have been described in patients with toxoplasmosis. Case report: We describe the case of a 13-year-old female patient with a history of untreated HIV who presented with hyperferritinemic sepsis secondary to Toxoplasma gondii infection and Pneumocystis jirovecci pneumonia. She received ventilatory support, inotropic drugs, treatment for opportunistic germs, and high-dose corticosteroids, but with unfavorable evolution. Conclusions: The global approach to sepsis with elevated ferritin guides to using of therapies aimed at neutralizing the severe inflammatory response. A timely diagnosis would allow prompt treatment and minimize complications.",

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year = "2023",

month = jul,

doi = "10.24875/BMHIM.22000051",

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T1 - Hyperferritinemic sepsis secondary to invasive Toxoplasma gondii in a child with untreated HIV

AU - Domínguez-Rojas, Jesús

AU - Caute-Lara, Jackeline

AU - Caqui-Vilca, Patrick

AU - Cruz-Arpi, Mario

AU - Martel-Ramírez, Carlos

AU - Quispe-Chipana, Miguel

AU - Sánchez-Rodríguez, Abel

AU - Atamari-Anahui, Noé

PY - 2023/7

Y1 - 2023/7

N2 - Background: Untreated human immunodeficiency virus (HIV)-immunosuppressed pediatric patients show high morbidity and mortality from opportunistic infections. Limited cases of hyperferritinemic sepsis have been described in patients with toxoplasmosis. Case report: We describe the case of a 13-year-old female patient with a history of untreated HIV who presented with hyperferritinemic sepsis secondary to Toxoplasma gondii infection and Pneumocystis jirovecci pneumonia. She received ventilatory support, inotropic drugs, treatment for opportunistic germs, and high-dose corticosteroids, but with unfavorable evolution. Conclusions: The global approach to sepsis with elevated ferritin guides to using of therapies aimed at neutralizing the severe inflammatory response. A timely diagnosis would allow prompt treatment and minimize complications.

AB - Background: Untreated human immunodeficiency virus (HIV)-immunosuppressed pediatric patients show high morbidity and mortality from opportunistic infections. Limited cases of hyperferritinemic sepsis have been described in patients with toxoplasmosis. Case report: We describe the case of a 13-year-old female patient with a history of untreated HIV who presented with hyperferritinemic sepsis secondary to Toxoplasma gondii infection and Pneumocystis jirovecci pneumonia. She received ventilatory support, inotropic drugs, treatment for opportunistic germs, and high-dose corticosteroids, but with unfavorable evolution. Conclusions: The global approach to sepsis with elevated ferritin guides to using of therapies aimed at neutralizing the severe inflammatory response. A timely diagnosis would allow prompt treatment and minimize complications.

KW - Child

KW - Ferritin

KW - Hemophagocytic

KW - Human immunodeficiency virus

KW - Lymphohistiocytosis

KW - Sepsis

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U2 - 10.24875/BMHIM.22000051

DO - 10.24875/BMHIM.22000051

M3 - Artículo

C2 - 36917806

AN - SCOPUS:85169838493

SN - 0539-6115

VL - 80

SP - 7

EP - 11

JO - Boletin Medico del Hospital Infantil de Mexico

JF - Boletin Medico del Hospital Infantil de Mexico

ER -

Hyperferritinemic sepsis secondary to invasive Toxoplasma gondii in a child with untreated HIV

Abstract

Keywords

UN SDGs

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