Treatment guidelines for COVID-19 infected patients.

Carlos Alva-Díaz, Victor Velásquez-Rimachi, Cristian Morán-Mariños, Mariela Osores-Flores, Jorge Chachaima-Mar, Andrely Huerta-Rosario, Roberto A. Molina, Oscar Rivera-Torrejón, Isabel Pinedo-Torres, Boris Verona-Mesia, Mariela Huerta-Rosario, Kevin Pacheco-Barrios, Tatiana Metcalf

Research output: Contribution to journalReview articlepeer-review

Abstract

BACKGROUND: New information for potential treatments against SARS-CoV-2 is rapidly increasing. As a result, countries and organizations have begun to release therapeutic guidelines. OBJECTIVE: To provide a synopsis of the recommendations supported in evidence-based guidelines for therapeutic options with potential activity against SARS-CoV-2. METHOD: Rapid systematic review of guidelines and/or protocols that provide interim clinical guidance for COVID-19 disease were extracted from PubMed/Medline, Web of Science, Scopus, Scielo, Google Scholar, and a general Google search. Duplicates were removed and a summary of the proposed interventions was included. A benefit risk analysis was then conducted. RESULTS: Twenty guidelines and/or protocols were selected; the majority of which came from Europe and Latin America. Seventeen interventions were identified and classified into 6 pharmacological groups. Antimalarials, lopinavir/ritonavir and remdesivir were the only agents recommended and supported by clinical trials. The remaining interventions were recommended based on indirect evidence, observational studies, or in vitro studies. CONCLUSIONS: Antimalarials have shown results against COVID-19 with surrogate outcomes and the presence of serious adverse events. We recommend active monitoring of agents with potential efficacy against SARS-CoV-2 and incorporating the results in national guidelines and protocols. Clinical trials should be conducted to show direct benefit with clinically relevant outcomes in various populations.

Translated title of the contributionTreatment guidelines for COVID-19 infected patients.
Original languageSpanish
Pages (from-to)509-529
Number of pages21
JournalMedicina Interna de Mexico
Volume34
Issue number4
DOIs
StatePublished - Jul 2020

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