Exploring the theranostic potentials of miRNA and epigenetic networks in autoimmune diseases: A comprehensive review

Sagnik Nag, Oishi Mitra, Garima Tripathi, Souvik Samanta, Bikramjit Bhattacharya, Priti Chandane, Sourav Mohanto, Vino Sundararajan, Sumira Malik, Sarvesh Rustagi, Suraj Adhikari, Aroop Mohanty, Darwin A. León-Figueroa, Alfonso J. Rodriguez-Morales, Joshuan J. Barboza, Ranjit Sah*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations

Abstract

Background: Autoimmune diseases (AD) are severe pathophysiological ailments that are stimulated by an exaggerated immunogenic response towards self-antigens, which can cause systemic or site-specific organ damage. An array of complex genetic and epigenetic facets majorly contributes to the progression of AD, thus providing significant insight into the regulatory mechanism of microRNA (miRNA). miRNAs are short, non-coding RNAs that have been identified as essential contributors to the post-transcriptional regulation of host genome expression and as crucial regulators of a myriad of biological processes such as immune homeostasis, T helper cell differentiation, central and peripheral tolerance, and immune cell development. Aims: This article tends to deliberate and conceptualize the brief pathogenesis and pertinent epigenetic regulatory mechanism as well as miRNA networks majorly affecting five different ADs namely rheumatoid arthritis (RA), type 1 diabetes, multiple sclerosis (MS), systemic lupus erythematosus (SLE) and inflammatory bowel disorder (IBD) thereby providing novel miRNA-based theranostic interventions. Results & Discussion: Pertaining to the differential expression of miRNA attributed in target tissues and cellular bodies of innate and adaptive immunity, a paradigm of scientific expeditions suggests an optimistic correlation between immunogenic dysfunction and miRNA alterations. Conclusion: Therefore, it is not astonishing that dysregulations in miRNA expression patterns are now recognized in a wide spectrum of disorders, establishing themselves as potential biomarkers and therapeutic targets. Owing to its theranostic potencies, miRNA targets have been widely utilized in the development of biosensors and other therapeutic molecules originating from the same.

Original languageEnglish
Article numbere1121
JournalImmunity, inflammation and disease
Volume11
Issue number12
DOIs
StatePublished - Dec 2023

Keywords

  • autoimmune diseases
  • diagnostics
  • epigenetic regulation
  • miRNA
  • therapeutics

Fingerprint

Dive into the research topics of 'Exploring the theranostic potentials of miRNA and epigenetic networks in autoimmune diseases: A comprehensive review'. Together they form a unique fingerprint.

Cite this