In vivobronchodilator evaluation of the ethanolic extract of the stems of Jatropha macranthaMüll.Arg.

Haydee Chávez, Freddy Palomino, Jackeline Angelino, Ernesto Torres, María R. Bendezú, Jorge A. García, Berta Loja, Ana M. Muñoz, Angel T. Alvarado

Research output: Contribution to journalArticlepeer-review

Abstract

Context: Asthma is characterized by hyperresponsiveness and bronchoconstriction, induced by histamine and other noxes, with a prevalence in Peru of 20.7-28.2%, which is why, in traditional medicine, Jatropha macrantha Müll.Arg is used. Aims: To evaluate the in vivo bronchodilator activity of the ethanolic extract of the stems of J. macrantha. Methods: The powdered material of the stem of J. macrantha was extracted with ethanol 96° by maceration; then, the phytochemical screening was carried out. The doses of 200, 400 and 800 mg/kg of the extracts were subjected to in vivo evaluation in guinea pigs (Cavia porcellus) with 1% histamine-induced bronchoconstriction, determining the latency period and the intensity of the effect. Results: Phytochemical sieving showed alkaloids, catechins, flavonoids, tannins and terpenes. The activity was observed at the three doses of the J. macrantha extract, being higher at a single dose of 400 mg/kg, with a latency period of 33.0 ± 1.02 s, asphyxia 84.5 ± 1.08 s and anaphylaxis 105.6 ± 0.59 s. The analysis of variance and Dunnett's test resulted with p<0.05 as statistically significant. Conclusions: The results showed bronchodilator activity of the ethanolic extract of J. macrantha at an average dose of 400 mg/kg, orally, in Cavia porcellus.

Translated title of the contributionIn vivobronchodilator evaluation of the ethanolic extract of the stems of Jatropha macranthaMüll.Arg.
Original languageSpanish
Pages (from-to)937-946
Number of pages10
JournalJournal of Pharmacy and Pharmacognosy Research
Volume9
Issue number6
StatePublished - Nov 2021
Externally publishedYes

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