Electroencephalography Signatures for Conditioned Pain Modulation and Pain Perception in Nonspecific Chronic Low Back Pain-An Exploratory Study

Paulo E.P. Teixeira, Kevin Pacheco-Barrios, Elif Uygur-Kucukseymen, Roberto Mathias Machado, Ana Balbuena-Pareja, Stefano Giannoni-Luza, Maria Alejandra Luna-Cuadros, Alejandra Cardenas-Rojas, Paola Gonzalez-Mego, Piero F. Mejia-Pando, Timothy Wagner, Laura Dipietro, Felipe Fregni

Research output: Contribution to journalArticlepeer-review

Abstract

 : Conditioned pain modulation (CPM) can discriminate between healthy and chronic pain patients. However, its relationship with neurophysiological pain mechanisms is poorly understood. Brain oscillations measured by electroencephalography (EEG) might help gain insight into this complex relationship. OBJECTIVE: To investigate the relationship between CPM response and self-reported pain intensity in non-specific chronic low back pain (NSCLBP) and explore respective EEG signatures associated to these mechanisms. DESIGN: Cross-sectional analysis. PARTICIPANTS: Thirty NSCLBP patients participated. METHODS: Self-reported low back pain, questionnaires, mood scales, CPM (static and dynamic quantitative sensory tests), and resting surface EEG data were collected and analyzed. Linear regression models were used for statistical analysis. RESULTS: CPM was not significantly correlated with self-reported pain intensity scores. Relative power of EEG in the beta and high beta bands as recorded from the frontal, central, and parietal cortical areas were significantly associated with CPM. EEG relative power at delta and theta bands as recorded from the central area were significantly correlated with self-reported pain intensity scores while controlling for self-reported depression. CONCLUSIONS: Faster EEG frequencies recorded from pain perception areas may provide a signature of a potential cortical compensation caused by chronic pain states. Slower EEG frequencies may have a critical role in abnormal pain processing.

Original languageEnglish
Pages (from-to)558-570
Number of pages13
JournalPain Medicine
Volume23
Issue number3
DOIs
StatePublished - 2 Mar 2022

Keywords

  • Chronic Low Back Pain
  • Chronic Pain
  • Conditioned Pain Modulation
  • EEG Signature
  • Pain Perception

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