Determination of PaO2/FiO2 after 24 h of invasive mechanical ventilation and 1PaO2/FiO2 at 24 h as predictors of survival in patients diagnosed with ARDS due to COVID-19

Miguel Hueda-Zavaleta, Cesar Copaja-Corzo, Brayan Miranda-Chávez, Rodrigo Flores-Palacios, Jonathan Huanacuni-Ramos, Juan Mendoza-Laredo, Diana Minchón-Vizconde, Juan Carlos Gómez de la Torre, Vicente A. Benites-Zapata

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction. Acute respiratory distress syndrome (ARDS) due to Coronavirus Disease 2019 (COVID-19) causes high mortality. The objective of this study is to determine whether the arterial pressure of oxygen/inspiratory fraction of oxygen (PaO2/FiO2) 24 h after invasive mechanical ventilation (IMV) and the difference between PaO2/FiO2 at 24 h after IMV and PaO2/FiO2 before admission to IMV (1PaO2/FiO2 24 h) are predictors of survival in patients with ARDS due to COVID-19. Methods. A retrospective cohort study was conducted that included patients with ARDS due to COVID-19 in IMV admitted to the intensive care unit (ICU) of a hospital in southern Peru from April 2020 to April 2021. The ROC curves and the Youden index were used to establish the cut-off point for PaO2/FiO2 at 24 h of IMV and 1PaO2/FiO2 at 24 h associated with mortality. The association with mortality was determined by Cox regression, calculating the crude (cHR) and adjusted (aHR) risk ratios, with their respective 95% confidence intervals (95% CI). Results. Two hundred patients were analyzed. The average age was 54.29 years, 79% were men, and 25.5% (n = 51) died. The cut-off point calculated for PaO2/FiO2 24 h after IMV and 1PaO2/FiO2 24 h was 222.5 and 109.5, respectively. Those participants with a value below the cut-off point of 1PaO2/FiO2 24 h and PaO2/FiO2 24 h after IMV had higher mortality, aHR = 3.32 (CI 95% [1.82–6.07]) and aHR = 2.87 (CI 95% [1.48–5.57]) respectively. Conclusion. PaO2/FiO2 24 h after IMV and 1PaO2/FiO2 24 h in patients diagnosed with ARDS due to COVID-19 on IMV were associated with higher hospital mortality. These findings are helpful to identify those patients with a higher risk of dying on admission to the ICU.

Original languageEnglish
Article numbere14290
JournalPeerJ
Volume10
DOIs
StatePublished - Dec 2022

Keywords

  • COVID-19
  • Critical care
  • Hospital mortality
  • Mortality
  • Peru
  • Respiratory distress syndrome
  • SARS-CoV-2

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